Protein Alignment TSC22D2 and bun

DIOPT Version :9

• Sequence 1: NP_055594.1
• Gene: TSC22D2 / 9819
• HGNCID: 29095
• Length: 780
• Species: Homo sapiens
• Sequence 2: NP_001036357.2
• Gene: bun / 34665
• FlyBaseID: FBgn0259176
• Length: 1331
• Species: Drosophila melanogaster
• Alignment Length: 1115
• Identity: 255/1115 - (22%)
• Similarity: 360/1115 - (32%)
• Gaps: 426/1115 - (38%)

Human     7 KKKSCFQITSVTTAQVATSITEDT--ESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSE 69
            |..|.|:|||||......:...||  ||.||.|||.|:| :|.|.|:...|.         |.||
  Fly   262 KTTSSFEITSVTVGHPKLNAAGDTGDESADDLDESHTDD-NSRITDLENETP---------SMSE 316

Human    70 ETL--------NNVGDAETPGTVSPNLLLDGQLAAAAAAPANGGGVVSAR-SVSGALASTLAAAA 125
            :|.        ||......|  |.|.....|.:.....||:.|..:.:.: :||..:.:.::.|.
  Fly   317 DTFSKEEVYYANNALSTNAP--VIPTSSQYGLVVVDPIAPSLGQTIQNVQVNVSDNIINVVSGAV 379

Human   126 TSAPAPGAPGGPQLAGSSAGPVTAAPSQPPTT--CSSRFRVIKLDHGSGEPYRRGRWTCMEYYER 188
            |       |||           |........|  .|.||:|:|::  |.||::||||.||:|.:.
  Fly   380 T-------PGG-----------TKKKDDIKETQHRSERFKVVKIE--STEPFKRGRWMCMDYLDH 424

Human   189 DS-----DSSVLTRSGDCIRHSSTFDQTAERDSGLGATGGSVVVVVASMQGAHGPESGTDSSLTA 248
            .|     :::..|.|.....|::|.|..|   :|:||             |:..|...|..|:.
  Fly   425 SSVGNGGNNNEKTGSSTSEAHAATTDGGA---AGVGA-------------GSEAPAHKTTQSMI- 472

Human   249 VSQLPPSEKMSQP-----------TPAQPQSFSVGQPQPPPPPVGGAVAQS----------SAPL 292
               |||::|:::.           ..|:.|.....|.|.....||.|:.::          |:.:
  Fly   473 ---LPPTQKLNENHLEANSTDANWNYAEQQQQQQQQQQQQQTIVGNALTKTLPVALRNVSRSSSV 534

Human   293 PPFPGAATG-PQPMMAAAQPSQPQ------------GAGPGGQTLPPTNVTLA------------ 332
            ...|.|... ..|.:.|.|..|.|            ...|.|.   |.|:..|
  Fly   535 TRSPNATVEFLSPNLLAQQQQQQQQLFDSVNANAASSPNPAGD---PNNMDYARTAAMQLHQTLQ 596

Human   333 -----QPAMSLPPQPG----------PAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSEYLQ 382
                 :.||.:||..|          .||||.:.......|..:.|:            .:.|::
  Fly   597 QLKQREDAMDVPPGAGGYANYQNGGDSAVGAASNNNSAAAATGESQL------------STSYVE 649

Human   383 QHVAGLQPPSPA----QPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGP 443
            |.....||.|||    |.:.|.||.:...:....:...|......:|:.|...||       ..|
  Fly   650 QQQQQQQPLSPAPLTPQAAPTFAAVAAGQSPNFQLEQQQQQQQATSQIDGIVPQP-------FNP 707

Human   444 AQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGV-- 506
            .|..|..|.|.|          .|.....|.|....:.||||...:...:||..|....:|.:
  Fly   708 QQQQQQTPQQST----------AQQAAAAANATSAVTAPPPQQTSNTSNAAVTTGQGQTMPLLSH 762

Human   507 --------PNVPAAVPAPSVPSVSTTSVTMP---------NVPAPLA--------QSQQLSSH-- 544
                    ||:.||..|.:....:.|||..|         :.|:.:|        |.||...|
  Fly   763 MTSYEQQQPNLGAAAAAAAAGGTAATSVAAPQAIPTLQLQSAPSTIADPQQLMVPQQQQQQQHQE 827

Human   545 -------------TPVSRSSSIIQHVGLPL-------------------------------APGT 565
                         .|.:.:|:...:..|.|                               |.|.
  Fly   828 EQQQQPQQQQQPLPPANIASASANNSNLNLTNTNVVATGEATTNALTLTDEQATAALAAAFATGA 892

Human   566 HSAPT------SLPQSDLSQFQTQ------------------------TQPLVGQVDD------- 593
            .:|.|      :..|..:.|.|.|                        :.|.:|..:|
  Fly   893 AAAATGATSAAAATQQQIQQLQQQPNAESETESFITASNPGGNRKRAFSNPHIGGPNDPSFMHRL 957

Human   594 -------------------------------------------------------------TRRK 597
                                                                         ||..
  Fly   958 NPQLYYYNKSQSGRSSFCVDESLWPTNNPNGAVSDTNLYMGSSTDEDYEEAIDQFSPTIYTTRSA 1022

Human   598 SEPLPQP------PLSLIAENKPVV-------------KPPVADSLANPLQLTP-----MNSLAT 638
            |..:|.|      |...:..::|.:             :...|.|.:..:...|     .:|..|
  Fly  1023 SRAIPIPNSAGSSPQHQMHHSQPRIAIGINQMEGGGPTRSTGAFSASPSIYAYPHSPFYASSPET 1087

Human   639 SVFSIAIP----------------------VDGDEDRNPSTAFYQAFHLNTLKESKSLWD----- 676
            |..|.|:|                      .:...||.|.:....|.....:..:.:..|
  Fly  1088 SFGSAAMPGHPAASSRISFSYDPAFQRLQVPNASGDRRPRSPLECASVFAAVAAAATCGDAAGGA 1152

Human   677 ------SASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKS 735
                  ||||...|||||||||||||||||||.|||||||||||:|.||:::.:.||.||::|||
  Fly  1153 ADTVISSASGTSAVAIDNKIEQAMDLVKSHLMIAVREEVEVLKERISELMDKINKLELENSILKS 1217

Human   736 LSSNDQLSQL------------PTQQANP-----------GSTSQQQA--------VIAQPPQPT 769
            ....:.|.||            |..||.|           |...||||        |...|....
  Fly  1218 NIPQETLQQLQLQLQLAAPPATPAIQAAPAVQSVVAPAAAGQAVQQQAAGAVAVTGVATSPASAV 1282

Human   770 QPPQQPNVSS 779
            .|...||.|:
  Fly  1283 VPTSIPNGSA 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSC22D2	NP_055594.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..86		23/75 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..158		6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..499		69/328 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..607		8/93 (9%)
		TSC22	694..750	CDD:279505	34/67 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..780		18/75 (24%)
bun	NP_001036357.2	TSC22	1176..1223	CDD:279505	30/46 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154586
Domainoid	1	1.000	70	1.000	Domainoid score	I9543
eggNOG	1	0.900	-	-		E1_KOG4797
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4008
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42281
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.750