Protein Alignment SPOCK2 and Cow

DIOPT Version :10

• Sequence 1: NP_055582.1
• Gene: SPOCK2 / 9806
• HGNCID: 13564
• Length: 424
• Species: Homo sapiens
• Sequence 2: NP_001262857.1
• Gene: Cow / 42733
• FlyBaseID: FBgn0039054
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 678
• Identity: 140/678 - (20%)
• Similarity: 214/678 - (31%)
• Gaps: 320/678 - (47%)

Human     3 APGCGRLVLPLLLLAAAALAEGDAKGLKE--GETPGNFMEDEQWLSSISQYSGKIKHWNRFRDEV 65
            |..|    |.|:|::::.:...:|:..|:  |||.|:|                     .|.||:
  Fly     8 ASAC----LALVLMSSSLIGSTEARNKKKYVGETGGDF---------------------EFIDEI 47

Human    66 EDDYIKSWEDNQQGDE----ALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKL--------- 117
            .    |:.:.|:...|    ..|.:.|.|:.:.|.:.::|:.:....|:|:|:|:|
  Fly    48 N----KNTQSNKNLGEHKRWIHDPSSDLCRPLNCKKREICLLEDEFSAVCVSKKELHKNRDEIIT 108

Human   118 ---------EHRIKQ-----------------------------PT------VKLHGNKD----- 133
                     :.|:.|                             ||      ..:.||::
  Fly   109 KAKYLEEEAKRRVNQQDNQDSQDAEDINNDDEDNSSDGGSSNSSPTGTNNAQASVQGNEETDDED 173

Human   134 --------------------SI--------------------------------CKPCHMAQLAS 146
                                ||                                ||||.:|:...
  Fly   174 KSLSLGDDDESKEDDVFYENSIAAGDKQQQQQQLSQPAAGPSVIQQDDDEELDNCKPCPVAKPTF 238

Human   147 VCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPCPCPTEQAATSTADGK---------------- 195
            :||:|..||||:|:|:...|:.|..:.:.|:|.|||      ....|||
  Fly   239 LCGADNRTYSSLCRLDYHNCIHSTSIRIACKGFCPC------KEIVDGKRLQRISGYNNKYNKKI 297

Human   196 ----------------------------------------------------------------- 195
                                                                             
  Fly   298 SLDQQQQQQQQQQQQQQQQQAYKDSNNNNIMMNSGNIMGGNNNDFNTIMNDKEDNNRHNNHINAQ 362

Human   196 ----PE----------------------------------------------------------T 198
                ||                                                          .
  Fly   363 YTFTPEEIKYDNKHYKYLKYTAYKKDSKYQEDKHKMRNYNEVVEKQQQKFNKNSNLNAYPSKSAE 427

Human   199 CTGQDLADLGDRLRDWFQLLHENSK---QNGSASSVAGPASGLDKSLGASCKDSIGWMFSKLDTS 260
            |..|.|..:|:||.|||.::..:||   |:...|....|         .:||....|||..||.:
  Fly   428 CKPQQLTAIGNRLLDWFSVIMADSKKRRQHSQKSKAHFP---------PACKTEAKWMFGHLDLN 483

Human   261 ADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTAEWCFCFWREKPPCLAELERIQIQEA 325
            .|..|...|:..:..|:.|.||:||.::||...|..::|.|||.||.:...||.|...||....|
  Fly   484 NDGQLSLQEMYDLEHDQNERCIKPFIDTCDLDTDSSINTREWCRCFEKTDRPCAAVRRRIAGDFA 548

Human   326 AKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSGV 390
            .  :.|.:.|.||..|:|:..||..|.|.|||||:.|:|...|||.|.|:|:.:|..:....|
  Fly   549 G--EIGAYAPDCDIQGFYKPTQCHNSVGVCWCVDKHGVEFANTRTRGKPNCESVVNNAASLTS-- 609

Human   391 GWEDEEEKETEEAGEEAEEEEGEAGEAD 418
               |:|:       |.|::|:...|.||
  Fly   610 ---DDED-------EGADDEDSAEGSAD 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPOCK2	NP_055582.1	KAZAL	<147..180	CDD:197624	13/32 (41%)
		EFh_SPARC_TICN2	199..310	CDD:320017	39/113 (35%)
		EF-hand motif	246..277	CDD:320017	10/30 (33%)
		EF-hand motif	278..310	CDD:320017	14/31 (45%)
		Thyroglobulin_1	313..376	CDD:459665	27/62 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	387..424		9/32 (28%)
Cow	NP_001262857.1	KAZAL	<240..272	CDD:197624	13/31 (42%)
		EFh_SPARC_TICN	428..533	CDD:320011	39/113 (35%)
		EF-hand motif	469..500	CDD:320011	10/30 (33%)
		EF-hand motif	501..533	CDD:320011	14/31 (45%)
		TY	535..597	CDD:238114	28/63 (44%)