Protein Alignment SNX17 and Snx17

DIOPT Version :10

• Sequence 1: NP_055563.1
• Gene: SNX17 / 9784
• HGNCID: 14979
• Length: 470
• Species: Homo sapiens
• Sequence 2: NP_609353.1
• Gene: Snx17 / 34354
• FlyBaseID: FBgn0032191
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 515
• Identity: 204/515 - (39%)
• Similarity: 285/515 - (55%)
• Gaps: 75/515 - (14%)

Human     1 MHFSIPETESRSGDSGGS-AYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKL 64
            ||||||:|:    :.|.| .|.|||||:||:.||.:||.||..|::|||:......||.||||:|
  Fly     6 MHFSIPDTQ----ELGSSPTYTAYNIHINGIHHCVLRYKQLHSLNDQLRRHCVGVPLPPFPPKRL 66

Human    65 FSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQ----QVPT--EEVSLEV-L 122
            ..||..::|.||..||:|:|||.||..|..|.....||:|||.:|.    ||.|  ||..||| :
  Fly    67 LPLTNGQLEARRSSLEQYLQAVGQDNRLARSAHLQQFLQRAQLDTALAEGQVATDCEEQQLEVQV 131

Human   123 LSN--GQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLV-REKEDGAFSFVRKLQEFEL 184
            .:|  |:::|||.........:|::|..:|.|||:|:.:|.|||| |:::.|....||:|.:||.
  Fly   132 YTNPAGERILVNCSVQQNASALLKSVCRELQLPDELVRFFCLFLVRRQRKSGELHLVRRLMDFES 196

Human   185 PYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILV-TKEQHRQLK 248
            ||  :|.|..|..:::||..||||:.|..:..::|.|||||.|||:|:.|.|::: |..:.|||.
  Fly   197 PY--ITRLHVQPCELLLRTCYWDSSRDAKLTGSKVALNLLYNQTVADVNREWVVICTPGEGRQLN 259

Human   249 SLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSF 313
            |||.:...:|::.|.:.|..||.|:||....|:||.|...::|.||.||:|: ...|.::.|..|
  Fly   260 SLQMQGRAREYMDLVRQLPSYGCLQFDEAQVDYPEPDTMALISIGNKELALR-TARGVKIYETKF 323

Human   314 RVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQS 378
            ||||||.||| |...:...|...|      ..|:||||||:.|..|:|:||.|.||::||:|||:
  Fly   324 RVTRMRSWRV-SVTHITLESRLEP------THLQLAFEYLIGKQTLRWITINSDQAMLMSVCLQA 381

Human   379 MVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQ------------------------------AV 413
            |||||:.:.:|           .|..:.||.:|                              |.
  Fly   382 MVDELLQRGAG-----------SGKDQNSDEEQEQNAVTSSSSTPSSTCSTSTWASSTCSTSTAP 435

Human   414 KSPPL-LESPDATRESMVKL--SSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL 470
            .:||: ..|.|:...|..:|  |....||..|   :...|..|...:|  |||||||:||
  Fly   436 TTPPVRFLSEDSAPRSKPRLTTSRTFGAVFFR---NDVVDNGARVANG--AFEGIGDDDL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX17	NP_055563.1	PX_SNX17_31	2..106	CDD:132795	51/104 (49%)
		FERM-like. /evidence=ECO:0000269|PubMed:39587083	115..432		129/352 (37%)
		FERM_F1_SNX17	115..207	CDD:340538	37/95 (39%)
		FERM-like_C_SNX17	269..388	CDD:270145	55/118 (47%)
		PTB-like F3 module	270..432		65/192 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..426		9/55 (16%)
		Interacts with the retriever complex. /evidence=ECO:0000269|PubMed:39587083	458..470		8/11 (73%)
Snx17	NP_609353.1	PX_SNX17_31	7..108	CDD:132795	51/104 (49%)
		FERM_F1_SNX17	125..217	CDD:340538	35/93 (38%)
		FERM-like_C_SNX17	280..391	CDD:270145	55/118 (47%)