Protein Alignment ZFYVE16 and zfyve16

DIOPT Version :9

• Sequence 1: NP_001098721.2
• Gene: ZFYVE16 / 9765
• HGNCID: 20756
• Length: 1539
• Species: Homo sapiens
• Sequence 2: XP_005155592.1
• Gene: zfyve16 / 794689
• ZFINID: ZDB-GENE-091116-62
• Length: 1384
• Species: Danio rerio
• Alignment Length: 1635
• Identity: 654/1635 - (40%)
• Similarity: 861/1635 - (52%)
• Gaps: 356/1635 - (21%)

Human     1 MDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCS----VSSELASSQRTSLLPKDQE 61
            |||||||||.||||||||||.:.:|   |:.....|.|..|.    :.......|.|  :|:...
Zfish     1 MDSYFKAAVCDLDKLLDDFELSAEE---LESKPGTYVSPPCPDSTLIPGRFIPEQHT--VPQTLP 60

Human    62 CVNSCASSETSYGTNESSL--NEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSK 124
            .||:     ..||....|:  |:|     .|..||..:||:|||||||........|....|..|
Zfish    61 DVNA-----LHYGLTSQSIDSNQK-----DSYSNEWPLTGVDLLSSVDSRGIKSSAPPCPDRSLK 115

Human   125 PICDLISDMG--NLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTPCVSSTDHDSDTVRE 187
            |:|||::|.|  ||..| :|:||.|:|                     |.|.|.||:
Zfish   116 PVCDLVNDTGSANLQQA-DSQEDFKEL---------------------DIPDVQSTE-------- 150

Human   188 QQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESIVDFNMSSALTRQS 252
                                |:.||        :...|:|
Zfish   151 --------------------GLLVD--------FESPEDL------------------------- 162

Human   253 SKMFHAKDKLQHKSQPCGLLK--DVGL--VKEEVDVAVITAAECLKEEGKTSALTCSLPKN---- 309
            ||..|::...:.....|..|.  ||.|  |.|....:.||   .|:.|......:.|..:|
Zfish   163 SKPSHSEILKRDSEINCNSLSLLDVILPVVGEPYTSSSIT---LLETESSCPEASNSNGQNDRPW 224

Human   310 -----EDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLDLKDNDVIQDSSSALHVSSK 369
                 :|:|....::.:||..    :|.|:..|   |.|.||.|.|:::.:.:..|.:    |.|
Zfish   225 SQMDEDDVCNTCPSTTEENIS----AFSEEHAV---SLQPDSTSEDVRNPEDLTGSPT----SEK 278

Human   370 DVPSSLSCLPASGSMCGSL-----------IESKARGDFLPQHEHKDNIQDAVTIHEEIQNSVVL 423
            :  |||||||.:.||||||           :|:|...:.    |.|..||:|..:...::..|
Zfish   279 E--SSLSCLPMAVSMCGSLVATLDPQKAAVVETKDEAEL----ETKSAIQEAEELTLPLEEPV-- 335

Human   424 GGEPFKEN--DLLKQEKCKSILLQS-------LIEGMEDRKIDP-DQTVIRAESLDGGDTSSTVV 478
              .||..:  |...:::.:.:.:.|       ..|....|.:.| |:...|  .|...:.|.:..
Zfish   336 --PPFSSSRPDSSPEDEPEIVQIMSNPAAAGHYPERNFKRTLSPTDKLTCR--DLGASNPSPSYS 396

Human   479 ES-----QEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGP-----LISD--- 530
            ||     :.|::..::|||..      ......|   ::||.|.:.:|.|..|     ..||
Zfish   397 ESPNYSYEFGIANDYLPESDQ------TVMMVTD---EELDAFLMGQGVKINPDAAVEKFSDDGF 452

Human   531 ------AELDAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGES 589
                  ||.|.||.|: ||:..:::|....:|....:.                         ||
Zfish   453 SEFNGNAERDGFLDEE-LQSCKVETFASPESDGSQYLE-------------------------ES 491

Human   590 HGINIICEIVDKQNTIENGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSV-GGARPKQLF 653
            .|.|:       .::.::...|...||..:.....||..||.   ||...|.:|. ||||||||
Zfish   492 EGSNV-------SSSSQDSSPLRADSTQTITHETVTSPVEIQ---SVCSPNQESTYGGARPKQL- 545

Human   654 SLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTAD-PQVSFNSNYIDIESNS----- 712
                    |....:|         ||....:......:..:|: .|||.|.:.|:.|..|
Zfish   546 --------SNQTVRP---------PSERHRISHAEADVGGSANGSQVSPNQDEINCEPPSYQQYD 593

Human   713 -------------------EGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQV 758
                               |.|.|.|..:....      ||  ||.|||.|||||||||||||..
Zfish   594 SSYGCDELSEPPPYPGEMLEDGESSVDLSGHGA------EG--LGSKQPPWVPDSEAPNCMNCMQ 650

Human   759 KFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYETISKAQAFERMMSPTGSNLKS 823
            |||||||||||||||||:|..||||||:|:||:|||||||:|:.||.:|||.||||||||.:...
Zfish   651 KFTFTKRRHHCRACGKVYCASCCNRKCRLKYLDKEARVCVICHVTIQRAQAHERMMSPTGPSPNP 715

Human   824 N-HSDECTTVQPPQENQ---TSSIPSPATL-PVSALKQPGVEGLCSKEQKRVWFADGILPNGEVA 883
            | .|:.|:|:.|.|:.:   |.:.|.|..: |||.||.||.:|. .:|||.||||||||||||||
Zfish   716 NIPSEYCSTIPPMQQARAAGTLNSPPPTVMVPVSVLKHPGNDGF-PREQKHVWFADGILPNGEVA 779

Human   884 DTTKLSSGSKRCSEDFSPLSPDVPMTVNTVDHSHSTTVEKPNNETGDITRNEIIQSPISQVPSVE 948
            ||||||..::|.|::.||::||.|                               :|..:.|...
Zfish   780 DTTKLSVQTRRSSQESSPVTPDPP-------------------------------APDDKFPDER 813

Human   949 KLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSPTGVLVNSNLPIASISDYRLLCDINKYVCNKIS 1013
            :.|:. |....|.               |.|.|         |:....||.|||.:...|....|
Zfish   814 EESVG-GRSDSPV---------------EASRP---------PVRGPWDYGLLCGVGNCVQRDAS 853

Human  1014 LLPNDEDSLPPLLVASG--EKGSVPVVEEHPSHEQIILLLEGESFHPVTFVLNANLLVNVKFIFY 1076
            |:|.|:|.|||||:.:|  |:|.: :|||.|:..||:||||.....|:|||||||||||||.:.|
Zfish   854 LVPEDDDGLPPLLIITGEEEEGDL-LVEERPAACQILLLLEEGGPQPLTFVLNANLLVNVKIVTY 917

Human  1077 SSDKYWYFSTNGLHGLGQAEIIILLLCLPNEDTIPKDIFRLFITIYKDALKGKYIENLDNITFTE 1141
            ...:.|..|:|||.|:||.|::.::.|||.|:::|:|:|.|:::||:||.|||:||:|.|:|||:
Zfish   918 CGKRCWCLSSNGLQGVGQKELVFIIECLPEENSLPRDVFNLYVSIYQDAQKGKFIEHLGNVTFTD 982

Human  1142 SFLSSKDHGGFLFITPTFQKLDDLSLPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPA 1206
            |||.||||||.||.|.|||.|:.|:||...||||:||||||:|||||||:||:|.|||:|..||.
Zfish   983 SFLGSKDHGGVLFFTATFQPLEGLALPQVSFLCGVLIQKLEVPWAKVFPLRLLLALGAKYSVYPC 1047

Human  1207 PLTSIRGRKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLN 1271
            ||.|||.|:.:|.|.||||||||.|||||||:|..::.|.:|||||.|.|:||:.::::::||:|
Zfish  1048 PLMSIRFRESVFKETGHTIMNLLTDLRNYQYSLPVVESLRVHMEMGNSYIEIPKSRFNEMLKVVN 1112

Human  1272 SSNEHVISIGASFSTEADSHLVCIQN-DGIYETQANSATGHPRKVTGASFVVFNGALKTSSGFLA 1335
            ||||||||.||.|||||||||||||| ||.|:|.|||..|..|:||||||||||||||.||||:|
Zfish  1113 SSNEHVISFGACFSTEADSHLVCIQNEDGSYQTSANSIPGKTRRVTGASFVVFNGALKASSGFIA 1177

Human  1336 KSSIVEDGLMVQITPETMNGLRLALREQKDFKITCGKVDAVDLREYVDICWVDAEEKGNKGVISS 1400
            |||||||||||||.||||.|||.|||:|.||:|.|||.|:.:.||.|::.|||.....|.||.|.
Zfish  1178 KSSIVEDGLMVQIPPETMEGLRQALRDQNDFQIPCGKTDSEETRENVNVRWVDWTAPVNAGVTSP 1242

Human  1401 VDGISLQGFPSEKIKLEADFETDEKIVKCTEVFYFLKDQDLS---ILSTSYQFAKEIAMACSAAL 1462
            |||.||:|..|.||:.:::||.|.:.::||||||.||..|:|   ||::|.||.:|||.|..|||
Zfish  1243 VDGKSLEGVSSVKIQQDSEFEMDGRTIRCTEVFYLLKSSDVSLPAILTSSAQFQREIATASCAAL 1307

Human  1463 CPHLKTLKSNGMNKIGLRVSIDTDMVEFQAGSEGQLLPQHYLNDLDSALIPVIHGGTSNSSLP-- 1525
            ||||..|.:||.|.:.||||.|:||||:||||.|:||||.|:||||.|||||||||  :|.:|
Zfish  1308 CPHLSVLMANGFNSLALRVSTDSDMVEYQAGSSGRLLPQKYMNDLDGALIPVIHGG--SSCVPHQ 1370

Human  1526 -LEIELVFFI 1534
             :::|..|:|
Zfish  1371 AMDMEFFFYI 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZFYVE16	NP_001098721.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	469..491		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..678		12/38 (32%)
		FYVE_endofin	738..804	CDD:277268	52/65 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..850		12/38 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	884..907		12/22 (55%)
		DUF3480	1167..1515	CDD:371829	227/351 (65%)
zfyve16	XP_005155592.1	FYVE_endofin	630..696	CDD:277268	52/65 (80%)
		SARA	712..750	CDD:288292	11/37 (30%)
		DUF3480	1008..1360	CDD:288806	227/351 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	454	1.000	Domainoid score	I3502
eggNOG	1	0.900	-	-		E1_KOG1841
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8826
Inparanoid	1	1.050	947	1.000	Inparanoid score	I2570
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114648at7742
OrthoFinder	1	1.000	-	-		FOG0003142
OrthoInspector	1	1.000	-	-		oto49363
orthoMCL	1	0.900	-	-		OOG6_105532
Panther	1	1.100	-	-	LDO	PTHR46319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X2534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.360