Protein Alignment HDAC4 and HDAC3

DIOPT Version :10

• Sequence 1: XP_011510519.1
• Gene: HDAC4 / 9759
• HGNCID: 14063
• Length: 1113
• Species: Homo sapiens
• Sequence 2: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 384
• Identity: 96/384 - (25%)
• Similarity: 159/384 - (41%)
• Gaps: 73/384 - (19%)

Human   702 SSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAH-TLLYGTNPLNRQKLDSK 765
            :.||....|:....|.:...||..|.:..|..||:.:::...||:.: ..|....|.|.| .:|.
  Fly    21 AGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQ-CNSV 84

Human   766 KLLGSLASVFVRLPC-------------GGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATG 817
            .....||...|...|             .|..::.....|..||......:.|.
  Fly    85 AYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGL----------- 138

Human   818 ELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVA-AKLLQQRLSVSKILIVDWDVHHGNGTQQAFY 881
                         |||::....||||.|.:.:. .:||:..   .::|.:|.|||||:|.|:|||
  Fly   139 -------------HHAKKFEASGFCYVNDIVIGILELLKYH---PRVLYIDIDVHHGDGVQEAFY 187

Human   882 SDPSVLYMSLHRYDDGN-FFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVM 945
            ....|:..|.|:|  || ||||:|...|:|...|..::||:....|:|    |..|...|:.::.
  Fly   188 LTDRVMTASFHKY--GNYFFPGTGDMYEIGAESGRYYSVNVPLKEGID----DQSYFQVFKPIIS 246

Human   946 PIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDL--T 1008
            .|...:.|..:::..|.|::.|  ..||.::||.:..|...|.:..|....:|:. .||:.|  .
  Fly   247 AIMDFYRPTAIVLQCGADSLAG--DRLGCFSLSTKGHGECVKFVKELNVPTLVVG-GGGYTLRNV 308

Human  1009 AICDASEACVSALLGNELD---PLPE-------------KVLQQRPNANAVRSMEKVME 1051
            |.|...|  .|.|:..:::   |..|             ::..::.|||:.:.:|.:::
  Fly   309 ARCWTHE--TSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVK 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	XP_011510519.1	ClassIIa_HDAC4_Gln-rich-N	<115..176	CDD:197398
		HDAC4	678..1086	CDD:212530	96/384 (25%)
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	96/384 (25%)