Protein Alignment HDAC4 and HDAC11

DIOPT Version :10

• Sequence 1: XP_011510519.1
• Gene: HDAC4 / 9759
• HGNCID: 14063
• Length: 1113
• Species: Homo sapiens
• Sequence 2: NP_733048.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 74/361 - (20%)
• Similarity: 128/361 - (35%)
• Gaps: 107/361 - (29%)

Human   704 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLE--ELQTVH-------SEAHTLL-------- 751
            |.|.....:.:|.:..:....||...:..|...:.  .|:.:|       ...|.||
  Fly     9 HHEEQESEEVVWVKRDDARSAGKLPIVFSRNYAVRFGGLERLHPFDAAKGKHIHKLLCAQLQLDD 73

Human   752 ---YGTNPLNR---QKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE- 809
               |....|.:   :::.:::.|.||.                  |:         :.|.|:.|
  Fly    74 GSFYEPTELTKDQLRRIHTREYLKSLR------------------WS---------MNVACIAEV 111

Human   810 ---------------------------LVFKVATGELKNGFAVVRPPG-HHAEESTPMGFCYFNS 846
                                       |..|:|   |..|:|:....| ||.......|||.:..
  Fly   112 PLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLA---LDYGWAINLGGGFHHCCSYRGGGFCPYAD 173

Human   847 VAVAAKLL--QQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEV 909
            :::....|  |:...|.:|:|||.|.|.|||.::.|.:..:|....::   :...:|......|
  Fly   174 ISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDMY---NAFVYPRDHVAKE- 234

Human   910 GTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGG 974
                    ::..|..  |.....|..||...:..:|...:||.||:|:.::|.|.:||  .|||.
  Fly   235 --------SIRCAVE--LRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEG--DPLGN 287

Human   975 YNLSARCFGYLTKQLMGLA-----GGRIVLALEGGH 1005
            ..:||.  |.:.:..:..:     |..:|:.|.||:
  Fly   288 LAISAE--GVIERDRLVFSTFRALGIPVVMLLSGGY 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	XP_011510519.1	ClassIIa_HDAC4_Gln-rich-N	<115..176	CDD:197398
		HDAC4	678..1086	CDD:212530	74/361 (20%)
HDAC11	NP_733048.1	HDAC_classIV	51..336	CDD:212519	67/319 (21%)