DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDAC6

DIOPT Version :9

Sequence 1:	XP_011510519.1	Gene:	HDAC4 / 9759	HGNCID:	14063	Length:	1113	Species:	Homo sapiens
Sequence 2:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster

Alignment Length:	1034	Identity:	269/1034 - (26%)
Similarity:	404/1034 - (39%)	Gaps:	273/1034 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   270 SEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSV 334
            |.|.:..||..:.|:..|               |:..:....|..|.::|.|:|.||.:.|.|..
  Fly     2 SPPIVTRRSAQQAKIQTR---------------AMASKSKTGTTGAATAAGGTGSSSGSISGGFN 51

Human   335 SAE--NGIAPAVPSIPAETSLAHRLVAREGSAA--------------------PLPLYTSPSLP- 376
            :|:  ....|....:.|:....:.::..:|..:                    |..|....|:.
  Fly    52 AADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQ 116

Human   377 --------------------------NIT---LGLPATGPSAG----------------TAGQQD 396
                                      |:|   |.||:...:..                |:|.:|
  Fly   117 HCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRD 181

Human   397 AERL-TLPALQQRLSLFPGT-HLTPYLSTSPLERDGGAAHSPLLQHMV--------LLEQPPAQA 451
            .||: .|.:....:.:.|.| .|:...|.|.:|         |:.|:|        .:.:||...
  Fly   182 DERMEELSSRYDSIYIHPSTFELSLLASGSTIE---------LVDHLVAGKAQNGMAIIRPPGHH 237

Human   452 PLVTDW----YLSGLGALPLHAQSLVGADRVS--------------------------------- 479
            .:..::    :.:.:.....||..:....|:.
  Fly   238 AMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHG 302

Human   480 ---PSIHKLRQH---RPLGRTQSAPLPQNAQAL---QHLVIQQQHQQFLEKHKQQFQQQQLQM-- 533
               |.:|:...|   ...|...:..:|.||..:   .:|.|   .||.|.....:||.:.:.:
  Fly   303 SFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAI---FQQLLLPVALEFQPELIIVSA 364

Human   534 --NKIIPKP-SEPARQPESHPEETEEELREHQA----LLDEPY-LDRLPGQKEAHAQAGVQVKQE 590
              :..:..| .|....|..:|......||...|    :|:..| ||.|        ..|..:...
  Fly   365 GYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSL--------AEGAALTLR 421

Human   591 PIESDEEEAEPPREVEPGQRQPSEQELLF-------RQQALLLEQ-------------QRIHQ-L 634
            .:..|  ...|..|..|..|....|.||.       ..:.|.|:|             :.:|. |
  Fly   422 SLLGD--PCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVL 484

Human   635 RNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFP----------VSVQEPPTK---PRFTTGLV 686
            |::            .||..|:.|..:...:...|          :.|....||   |.|.....
  Fly   485 RHW------------IGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYA 537

Human   687 YDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLL 751
            ||..||.| |.. :.:.|||...|||.|.....:.||..:.:.:..|.||.:|:...|:.||
  Fly   538 YDAQMLLH-CNL-NDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH--- 597

Human   752 YGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVAT 816
              .|.:.|......|.|...|.::            ::::....:...|.||.|.|::.|..|..
  Fly   598 --VNTVRRLLGREPKELHDAAGIY------------NSVYLHPRTFDCATLAAGLVLQAVDSVLR 648

Human   817 GELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFY 881
            ||.::|...|||||||||:..|.|||.||:||:||:...:...:.::||||||||||||||..|.
  Fly   649 GESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFE 713

Human   882 SDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVV 944
            |:|.|||:|||||:.|:|||  ..|..|.||.|.|.|||||:.:.   ...|||.||..||:.::
  Fly   714 SNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLI 775

Human   945 MPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTA 1009
            ||||.||.|.:||||:||||..|  .||||..::|..:|.||..|..||.|||::.||||:::.:
  Fly   776 MPIAYEFNPQLVLVSAGFDAAIG--DPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNS 838

Human  1010 ICDASEACVSALLGNELDPLP-----EKVLQQRPNA---NAVRSMEKVMEIHSKYWRCLQRTTST 1066
            |..|...|...|||   ||:|     ...||:.|..   :.|.|:::.:::...:||.|:    .
  Fly   839 ISYAMTMCTKTLLG---DPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLE----F 896

Human  1067 AGRSL-IEAQTCENEEAETVTAM----------ASLSVGVKPAEKRP---DEEPMEEEP 1111
            .||.| .:....||...:.:||.          |:.:.| ..|..||   ||.|...:|
  Fly   897 VGRRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAG-GLAGDRPDCGDERPSGSKP 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	XP_011510519.1	ClassIIa_HDAC4_Gln-rich-N	<115..176	CDD:197398
HDAC4	XP_011510519.1	HDAC4	678..1086	CDD:212530	162/421 (38%)
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	60/359 (17%)
		HDAC6-dom2	538..895	CDD:212527	153/383 (40%)
		zf-UBP	1007..1069	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750