Protein Alignment HDAC4 and HDAC4

DIOPT Version :10

• Sequence 1: XP_011510519.1
• Gene: HDAC4 / 9759
• HGNCID: 14063
• Length: 1113
• Species: Homo sapiens
• Sequence 2: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Alignment Length: 1342
• Identity: 461/1342 - (34%)
• Similarity: 661/1342 - (49%)
• Gaps: 365/1342 - (27%)

Human    49 VNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQIL 113
            ::.:||.......| |.:.|:.:.:|.:         ..||:   .:.|:::.||:.|::|:|.|
  Fly    10 IHDLPSEAGSDERL-LHITPATLTLDFK---------PHPAV---DIDQQIMELKKSQELQKQRL 61

Human   114 IAEFQRQHEQLSRQHEAQLHEHIKQQQ--------EMLAM------------------------- 145
            |..||.|.:|:..:|:.|| ||..|:|        |::.:
  Fly    62 INSFQEQSKQMELEHKLQL-EHKYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAA 125

Human   146 -----KHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKE-----SAVASTEVKMKLQ 200
                 :|:|:|  ||:: ::|:|:|: ::||::|:.||......|.:     ||.||.|||..|.
  Fly   126 AVAQEQHRQQL--HQQQ-QQHQQQQQ-QQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILN 186

Human   201 EFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNH------PVLGMYDA 259
            .|:|::|...|..  |...::.|....|..:.||  ..|.|...|::::.:      |.|..|::
  Fly   187 CFILSRKSQAAAS--NGTTTTSPYRNRGVVKSSS--GESLPAGTVTSAHPYKIPQPPPSLLKYES 247

Human   260 KDDFPLRKTASEPNLKLRSRLKQKVAERRS---SPL-LRRKDGPVVTALKKRPLDVTDSACSSAP 320
              ||||||||||||| |:.||||.|.||::   .|. .||.:..:..|.:::..:...:.|:|.|
  Fly   248 --DFPLRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTP 309

Human   321 GSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGS--AAP----------------- 366
            .|||:||                    |:..:||..:|...||  :||
  Fly   310 DSGPNSP--------------------PSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRS 354

Human   367 ----LPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQR------------------- 408
                |||::|||||||:||.|....||....|.:|:.......|.:
  Fly   355 SINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGC 419

Human   409 --------------------LSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPL 453
                                |::.|.|.:.|. ..||:.|...|..:...|..::.:..|.||..
  Fly   420 GQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQ-QPSPVVRSASATSTSSSQASLVGDVAPPQAHA 483

Human   454 V------TDWYLSGLGALP-----LHAQSLVGA-------------------------------- 475
            .      :..|:..||::.     |||.::..|
  Fly   484 ASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHG 548

Human   476 --------------------DRVSPSIHKLRQ-HRPLGRTQSAPLPQNAQALQHLVIQQQHQQFL 519
                                |.....:|..:| |||||||||||||.....|...|
  Fly   549 HGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAV--------- 604

Human   520 EKHKQQFQQQQLQMNKIIPKPSEPARQPESHPE--ETEEELREHQAL---LDEPYLDRLPGQKEA 579
                        |:|.:           ::|.|  |.|.:..|||.:   :.:..|.|......|
  Fly   605 ------------QLNVV-----------QTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAA 646

Human   580 HAQAGVQVKQE---PIESDEEEAE---------PPREV-------EPGQRQPS------------ 613
            .|.|||.|.:|   ..|.|:..||         ||:.|       ...|..|.
  Fly   647 AAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYR 711

Human   614 --------------------EQELL--FRQQALLLEQQR---IHQLRNYQASMEAAGIP------ 647
                                :||.|  .|:|.|||:|:.   ...:|....::.:..:|
  Fly   712 APHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGL 776

Human   648 --VSFGGHRPLSRAQSSPASATFPVSVQ---------------------------EPPTKPRFTT 683
              :...|.:|...|.||.|....||::.                           .||.|  .||
  Fly   777 SQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHK--VTT 839

Human   684 GLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAH 748
            ||.||.|||||.|.||.::.||||:||:||:|:||.||.|..:|:.:|.||||.|||||||:|||
  Fly   840 GLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH 904

Human   749 TLLYGTN--PLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELV 811
            .:|:|:|  .|:|.||::     :|::.||||.|||:|||.||.|||.|:|.|||:|.|||::|.
  Fly   905 AMLFGSNQCQLSRPKLEN-----TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLA 964

Human   812 FKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRL-SVSKILIVDWDVHHGNG 875
            .|.|.|:|:||||||||||||||.:..||||:|||:|:|||||:||: .|.:|||||||||||||
  Fly   965 LKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNG 1029

Human   876 TQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF 940
            ||||||..|.:||:|:||:||||||||:|.|.|.|:|.|:|||||::::|.|:||:|||||:|||
  Fly  1030 TQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAF 1094

Human   941 RTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGH 1005
            ||||||||..|.||:|||||||||..|||.|||||::|..|||::|::|:.||.|::|||||||:
  Fly  1095 RTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGY 1159

Human  1006 DLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRS 1070
            ||.||||:::.||.||||:...|:.:..|::.|..||:.:::|.:.|...:|.|::....|.|.|
  Fly  1160 DLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLS 1224

Human  1071 LIEAQTCENEEAETVTAMASLSV-GVKPAEKRPD-EEPMEEE 1110
            .:|....|::|:||:.|||.||: .:.....|.| ||||:::
  Fly  1225 ALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQD 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	XP_011510519.1	ClassIIa_HDAC4_Gln-rich-N	<115..176	CDD:197398	23/98 (23%)
		HDAC4	678..1086	CDD:212530	241/410 (59%)
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006	14/43 (33%)
		HDAC_classIIa	837..1211	CDD:212544	127/237 (54%)