Protein Alignment FRMPD4 and CG42788

DIOPT Version :10

• Sequence 1: NP_001355324.1
• Gene: FRMPD4 / 9758
• HGNCID: 29007
• Length: 1799
• Species: Homo sapiens
• Sequence 2: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Alignment Length: 1222
• Identity: 343/1222 - (28%)
• Similarity: 548/1222 - (44%)
• Gaps: 266/1222 - (21%)

Human    45 EGE-HICHHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQI 108
            ||. :.|:|.|:|:||.|....|...:...||||...:..||.|:|||:.:...::.|.......
  Fly   188 EGRLYYCNHMTQSAGWLPACEDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAPECIRWDE 252

Human   109 IPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERV 173
            .||.||:|:::|:..||||||||||:||:||.||.||||.|||.|||||:.:|.|.|..|||:.|
  Fly   253 HPPEPRQVQLQRNASLGFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHV 317

Human   174 IDLVRSCKESILLTVIQP-----YPSPKSAFISAAKKARLKSNPVKVRFSEEVIING-----QVS 228
            |.|||:|:..:.|.|.||     .|..||..:||.|:|:|:|.|.:|||:|.|.:||     ..:
  Fly   318 IQLVRACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSA 382

Human   229 ETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGA 293
            .::.|..:..|.|||||:|||||||||::|.:|:::||:.:|.:||.:...|.|||:||......
  Fly   383 FSLGDICVPPMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLK 447

Human   294 GTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERF 358
            ..||.||..||:|.::..||.:||:||||||:|||....:|.:||..|.:|||:|.||||.||||
  Fly   448 RNKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERF 512

Human   359 GPELKYDIALRLAALQMY-IATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSH 422
            .|||:.::|||||||.|: .|........|:::|.:|:|:|||.|:|.::.:.||.|.:::.:||
  Fly   513 APELQPELALRLAALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISH 577

Human   423 LVKANQNLVPPGKK-LSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISH 486
            .:|.|..:.....| |:.||||:|||..::.|..||.:.|.....:..:|   .|||.||:|:|.
  Fly   578 FLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFSTNQREGVER---VLLVSPRFGLSQ 639

Human   487 VINTKTNL----VALLADFSH--VNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLT 545
            :.:.:.::    ::.:.||:|  |||     |::....|.:.:|..:.:..:||..|....:.:.
  Fly   640 ISSARNSVQPQPISAIEDFTHVVVNR-----EDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVL 699

Human   546 AGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTT------FI------ 598
            .||||||..   ::.|:..::....::..|....:|.:|...|:.:....|      |:
  Fly   700 GGYYRLLTG---NVLNILREREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHSVNFLMAPPYH 761

Human   599 -----GEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEAD 658
                 |:.:|::.|....|....:::...::...|    .::.|....||:   ...|...||.
  Fly   762 PLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVMATE----LLEEAAKDSGLS---DSSGSNYCEG- 818

Human   659 YRSLAQRSLLTLSGPETLKKAQE------------------------------------------ 681
             ||......|.....:.|::.||
  Fly   819 -RSHLGSHQLEAKNEQVLRRVQELQHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLNSSKVS 882

Human   682 SPRGAKVSFIFGDFALDDGISPP----------TLGYETL----------LDEGPEML------- 719
            |..|::...|.|..|    |.||          ||..||:          |:..||..
  Fly   883 STEGSQGGTILGPGA----IIPPGHPLKHSDSLTLLAETINHELSGITQGLNAIPESAPVSTSAP 943

Human   720 --------------------EKQRNLYIGSANDMK--GLDLT--------------------PEA 742
                                :::.|.:....:|::  |.|.:                    |:.
  Fly   944 PTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGTDFSQSESDSESVASPAQSPTTRRPQM 1008

Human   743 EGIQFVENSVYANIGDVK---SFQAAEGIEEPLLHDICYAENTDD----------AEDEDEVSCE 794
            ..:|...:|. .::...|   |.:::.|:..|  ....:...|.|          .|..:..|.:
  Fly  1009 MLLQAAGSSA-GSVAPAKQQLSQRSSFGLHSP--DGTHFGAETKDYNLREYLQQLKEISNAASAD 1070

Human   795 EDLVVGEMNQPAILNLSGSSD-------DIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFR 852
            .|:...::::  |.......|       |:|||.::|||:..|..|     ||::..||||.||.
  Fly  1071 TDVAARQLSE--IYGFEVREDTFIETDTDLIDLRAIPPPQTPDELD-----SLSLMNAAPPKGFE 1128

Human   853 DSSDEEDSQSQAASFPEDKEKGS---SLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALE 914
            ..::|.||..|........:|.:   .|..:|| :|.|...|.:.|.:                :
  Fly  1129 GKAEELDSFLQQIMVAPPTQKATPAKELTPEEI-MSFIIPPPPNLEQQ----------------Q 1176

Human   915 ALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFL---AT 976
            .::..|.:....||..|....:...::.::|..::|..:.   |.||.:::|:     |.   .:
  Fly  1177 VVAPVETECLYSNSVQAKREFFQSVANGNNGTVSHSPHII---EYATVERKSK-----FSCCPTS 1233

Human   977 HEGYHPLAEEQTEFPASKT-----PAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEP 1036
            .:...|..||....|.:.|     |....||||:         :|..:..|.||:..:....|:|
  Fly  1234 KKEEQPGQEELQPPPRTPTTEQLSPPPARPPKSA---------ELLQRYSPKKQVRIAASPVMQP 1289

Human  1037 ETMETKSVTDYFSKLHMGSVAYSCTSK---RKSKLADGEGKAPPNGNTTGKK 1085
            :  |.:.:               |..:   |.|...||...:|.|..:..||
  Fly  1290 Q--ERREL---------------CPPQLPPRGSPTLDGSQSSPTNAVSGPKK 1324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMPD4	NP_001355324.1	WW	73..103	CDD:238122	11/29 (38%)
		PDZ_FRMPD1_3_4-like	115..189	CDD:467250	43/73 (59%)
		FERM_F1_FRMPD4	238..331	CDD:340690	48/92 (52%)
		B41	242..461	CDD:214604	102/220 (46%)
		FERM_C_FRMPD1_FRMPD3_FRMPD4	457..561	CDD:270004	28/109 (26%)
		LGNbd_FRMPD4	1012..1060	CDD:409274	7/47 (15%)
CG42788	NP_731964.2	WW	177..203	CDD:459800	6/14 (43%)
		WW	218..246	CDD:238122	10/27 (37%)
		PDZ_FRMPD1_3_4-like	259..333	CDD:467250	43/73 (59%)
		FERM_F1_FRMPD1_like	393..482	CDD:340608	46/88 (52%)
		B41	396..617	CDD:214604	102/220 (46%)
		PH-like	613..715	CDD:473070	29/112 (26%)
		PHA03247	<1105..1377	CDD:223021	62/276 (22%)