Protein Alignment KMT2B and SET1

DIOPT Version :10

• Sequence 1: NP_055542.1
• Gene: KMT2B / 9757
• HGNCID: 15840
• Length: 2715
• Species: Homo sapiens
• Sequence 2: NP_011987.1
• Gene: SET1 / 856519
• SGDID: S000001161
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 482
• Identity: 141/482 - (29%)
• Similarity: 198/482 - (41%)
• Gaps: 96/482 - (19%)

Human  2319 GGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWH 2383
            ||:::...:.......|.||.......:.|.| ::..:.||....|.....|.....:...|:.|
Yeast   610 GGYAKSNKRNLKRHNSLALDHTSLKRKKLSNG-IKPMAHLLNEETDSKETTPLNDEGITRVSKEH 673

Human  2384 HYSGE----ASSSEEEPPSPDDKENQAPKRTGP---HL---RFEISSEDGFS--VEAESLEGAWR 2436
            ....|    :||.|||..:||.|.....:.|.|   ||   :..:..::|.|  ::|.|:.....
Yeast   674 DEEDENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLHGIKPLVPDQNGSSDVLDASSMYKPTA 738

Human  2437 TLI-EKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQL---------PGAQRCQHYKFR 2491
            |.| |.|.....:......:.|.|.....:....|.:|.  :||         |.......||..
Yeast   739 TEIPEPVYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLIL--KQLLSTYTPTVTPETSAALEYKIW 801

Human  2492 YHQQGEGQEE---------------PPLNPHGAARAEVYLRKCTFDMFNFLASQHRV-------- 2533
            ..::...:||               ..|.|..:.:||.:.:.......|:|..:.||
Yeast   802 QSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLKINYLPHRRRVHQPLNTVN 866

Human  2534 --------LPEGATCDEEE-----------DEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGV 2579
                    .||  .|..||           .||......||::      .||:...:..|.|:|.
Yeast   867 IHNERNEYTPE--LCQREESSNKEPSDSVPQEVSSSRDNRASN------RRFQQDIEAQKAAIGT 923

Human  2580 -------------------YRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKG 2625
                               .|||||..||:...:|.|.||:|||.|..||..:.:.|||.|...|
Yeast   924 ESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNG 988

Human  2626 IG-CYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYD 2689
            || .|:||:|:..|:|||..|..||||||.|:|||.:::|.|.|::.|||:|||.|...||||||
Yeast   989 IGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYD 1053

Human  2690 YKFPIE-DASNKLPCNCGAKRCRRFLN 2715
            |||..| |...:|||.|||..|:.|||
Yeast  1054 YKFEREKDDEERLPCLCGAPNCKGFLN 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KMT2B	NP_055542.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Menin-binding motif (MBM). /evidence=ECO:0000269|PubMed:22327296	17..36
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..302
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..518
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..771
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..868
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	894..959
		zf-CXXC	958..1005	CDD:366873
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1146..1166
		PHD1_KMT2B	1203..1249	CDD:277064
		PHD2_KMT2B	1251..1300	CDD:277066
		PHD3_KMT2B	1337..1393	CDD:277068
		Bromo_ALL-1	1374..1516	CDD:99925
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1567
		ePHD_KMT2B	1581..1685	CDD:277164
		FYRN	1733..1780	CDD:461787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1806..1978
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2008..2093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2118..2162
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2280..2412		23/96 (24%)
		FYRC	2413..2497	CDD:197781	19/98 (19%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	2508..2513		0/4 (0%)
		SET_KMT2A_2B	2562..2715	CDD:380947	77/173 (45%)
SET1	NP_011987.1	AF-4	<11..>136	CDD:461550
		RRM_scSet1p_like	246..360	CDD:409743
		SET_assoc	422..486	CDD:432058
		N-SET	763..932	CDD:463344	31/178 (17%)
		SET_SET1	926..1076	CDD:380998	70/149 (47%)