|
Human 740 PLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQLF 804
||.......:||. ..|:||.|.|...| .|...:|......:.:::.:
Worm 110 PLSPFSDPSVPQI----SLQMQPAPLPSSYP----------RSQDFNGDVYTQIAAMQQQR---- 156
Human 805 KIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIK 869
|||||.....|..:....|:| |||.|.....| |.|.|
Worm 157 ---QQQQQNQVQQMLATQAQLMDE-------ISDGGGTNDSD--------RNSSP---------- 193
Human 870 HVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSR-RGKVEAAGPG 933
..::.|...| :.||:.:| ||: |.|
Worm 194 -----------------------------------FYQEASDYDE-DFVPASTRGRGR----GGG 218
Human 934 GESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQ 998
.:.:| |.||:.. |.|::.|...| .....::|......:.|.:|:
Worm 219 AKKKP-GRGGSTG-TRRQTNPGPSG----------FFSATQLQAMSGDFSHLHQPQ--------- 262
Human 999 CCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPG 1063
:......|:|:....|.:| ..|| .||.||.|.|......:|
Worm 263 ------------QTSSTRGKRGKRGNGTSVP--------RQPG-KGPGRGRGRGRGSAAAIA--- 303
Human 1064 PEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSE-----------------PGGPPA-PRRRTPRE 1110
.|.|.:..:...:..|.::.......:: |..||| |..:||..
Worm 304 -----QLAQLQQVQYGAQGAPMFNGAPQLHPTQPTVAPTLPPSVTYQNVAPTAPPAPPALQTPLP 363
Human 1111 NELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDF 1175
:.||...|..|..|:...::.|.:|... |:.:...| ..:...|:.:....|
Worm 364 DPLPSIVPSFQQAPQAVAIREVDELMLE---DESSRQSG---------GSRSDEPEYIRTAIV-- 414
Human 1176 KEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGL---HELVFCQVCCDPFHPFCLEEAERPL 1237
|.:.:.:|. ...:||:|.|.|. ..:|.|..|...:|.:|:
Worm 415 ---CRVNDEFLQ------------KACMCLVCGSIGKGPEGSMVACSNCAQTYHTYCV------- 457
Human 1238 PQHHDT---------WCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGP---SYPTRATR 1290
..||. |.|..|..|..|| .|....:||.|:.|..:||..|:.| ..|
Worm 458 -TLHDKLNSAVVGRGWRCLDCTVCEGCG-TGGDEANLLLCDECDVSYHIYCMKPLLDKIP----- 515
Human 1291 KRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMM 1355
:..|.|..|.||:.|........|:...| ||..|..|.: ||.|.|.|:.|: |::
Worm 516 -QGPWRCQWCSRCRRCNHKAASGNDLTSQG---LCFPCASLRK----CPRCERNYQLNE---KLI 569
Human 1356 QCAQCDHWVHAKCEGL-SDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSG------------ 1407
:|:||..|.|..|||| :||..| ....|.: .|..| :|: |...||
Worm 570 RCSQCSKWQHGACEGLYTDEQLE--QAAIDRM--RCSAC----RPK-RVQPSGFSDVDTVWCDYV 625
Human 1408 ALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGKQLHPGPCGLQAVSQRFEDGHYKSVHSFMED-- 1470
||.....::|: ||.. |...:.|. :::|..|....||...::.:||
Worm 626 ALDKDAHEILK----SKYT----------PSALKNHM----MESVGYRESFDHYDDDYNPLEDSS 672
Human 1471 --------------------------MVGI------LMRH------------------SEEGETP 1485
.:|| |.|| |::.:.|
Worm 673 DQVTPLPIPGQRGRGRGNPSGRRGMNRIGIGGFYAKLPRHRIQALTEEAAAAAASSEDSKQAKRP 737
Human 1486 DRRAGGQMKGLLLKLLESAFGWFDAHDPKY----------------WRRSTR------------- 1521
.:....|::......::.||....|.:.|. |.:.||
Worm 738 RKSRRSQLEDAYPPQIQEAFFGIKAVEGKVLVDTPVDEPFLAEFNGWYKRTRSTKAFELCMTASE 802
Human 1522 ----------------LP-----------------------NGVLPNAVL--------------- 1532
|| |..|.|::|
Worm 803 MLRTDIDENEFLDCVGLPNMETDALDDFDFNLLEDFDVDEENDELENSLLGAPGNTEMKEDAAEG 867
Human 1533 ------PPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDAD 1591
|.|.: ..|.|.|..:|...|.......|.:||.|:......:.|:.......|
Worm 868 IEGSYGPTSFN------LDQRPSTSSAGGSLGSQDPFHPGMNPANFAQHAPGVRNAIARSGSQTD 926
Human 1592 SKE-------------------AGRLLYIG--------------------QNEWTHVNCAIWSAE 1617
:.| ...:||.. |..|..:|..:....
Worm 927 NSERYQFSARWEEDEPNGLQATTAAVLYSNEKHGYLRQQFPNWVDRVKQIQKLWRTLNHEVRLDY 991
Human 1618 VFEENDGSLKNVHAAVARGRQMRCEL---CLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKK 1679
|....|...::.: |.|..|..: ...|...:|..:.:..|:.....:..| ...|:
Worm 992 VNRARDNRTRSGN----RPRPRRTNVQSTDSPPPPQMGFKVPANPSSNMMGSSEQS----MQPKQ 1048
Human 1680 VFCQKHTDLLDGKEIVNPDGFDVLRRVYVDFEGINFKRKFLTGLEPDAIN--------------- 1729
||...|..: ||. :||.|.:.:.|.|:.|.|...:.:|
Worm 1049 VFITHHLPM------------DVY-QVYQDLKRVKFDRERLNGSLEEQLNKARKQKKNLAAKKRQ 1100
Human 1730 -VLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCW--YRCRILEY-------- 1783
|...:...|..|...||::.:.:......:..::..:.::..||.. :...:.::
Worm 1101 MVKTQTAAPDYDGRNIDLNESDQQTLATLTEQIKVTQAEIELHRRDLKKHESNLSDFVMKHGILR 1165
Human 1784 RPWGPREEPAHLEAAEENQTIVH-----SPAPSSEPPGGEDPPLDTDVLVPGA----------PE 1833
.....:.|...|.|..:.|...| :....::..|...||: ::.|.| .:
Worm 1166 NEHEVKREDVQLSAIRDQQYAAHADEMLAQQAQNQGLGQVHPPV---LVAPQAAISLPMLNQQQQ 1227
Human 1834 RHSPIQNLD----PPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPL-----------GGVSFG 1883
.|..:..:. ||.:....:.||..| :|.:.|:..::|.| ||:...
Worm 1228 HHQRMMQMQMRGGPPGQFMMRAQPPQQP------QINMHNHEIAKRMLMQQFRNAHPVMGGIRHD 1286
Human 1884 PLPSP------GSPSSLTHHIPTVGDPDF-------PAPP---RRSRRPSPLAPRPP----PSRW 1928
.:..| ....::...:.||.:.:. |.|| :|..:..|..|..| |.::
Worm 1287 EITDPIMRDVYDCLEAIVFDVHTVAEREAMQAAGQQPPPPHIMQRMMQQHPGGPGGPRLIMPGQF 1351
Human 1929 ---------ASPPLKTSPQLRVPPPTSVV------------TALTPTSGE-------------LA 1959
..||....||:.|.||.:.. .:..|.:|| |.
Worm 1352 PQLQGRRIPQQPPPVQLPQVDVDPPKTAAKRKKGGGNPKKNASSYPAAGEYDAWIEQMRMRFRLC 1416
Human 1960 PPGPAPSPPPP------EDLGPDFEDMEV---------VSGLSAADLDFAASLLGTEP------- 2002
|..|.....|. |.:.....||.| |....|..:.....|.|.|.
Worm 1417 PDIPKKQKEPRLNRPGCEFVSHGLTDMAVRATKKRTPLVGEFGAMRVKRGTRLFGNEERGEKSIM 1481
Human 2003 FQE----EIVAAGAMGSSHGGPGDSSEEE----------SSPTSRYIHFPVTVVSAPG------- 2046
||: ::.....:.:.:..|..:.|:: ..|||...........|.|
Worm 1482 FQDLNLYQVEPQIRLFALYNNPLPTMEDDVFRDEEDQIIDKPTSALQKLLNKKRGASGAMDHIRS 1546
Human 2047 ----LAPSATPGAPR------------------------IEQLDGVDDGTDSEAEAVQQPRG--- 2080
:..:..|.||. |.:...||:..|......:|.|.
Worm 1547 RARYMEETNIPPAPERGMFYENVEAEEEVTVELVFNTCDITEESSVDEKKDVCGRLHEQIRDLLA 1611
Human 2081 ---------QGTPPSGPGVVRA----GVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPR 2132
:.|||..| |.|: ..:||. .:.......|||..:..:|. ...
Worm 1612 IKDEVAWSMEDTPPESP-VSRSPEPEATVGAV-QQTSSTSRAPSEATEREIKR---------EVE 1665
Human 2133 EESLPPAPPL----------ANGSQ-------------------PSQGLTASPAD---PTRTFAW 2165
||:.|.||.: .|.|| .::.|..:|.. .||....
Worm 1666 EEAAPVAPEIKREIVEPSQSQNSSQCKNCQKALESHSSTSIVTVKAEKLNLAPTGSVVTTRAAPV 1730
Human 2166 LPGAPGVRVLSLGPAPEPPK---------------------PATSKII----------LVNKLGQ 2199
.||.||.....:.|:.|..| |.|.:.: :.|||.|
Worm 1731 PPGVPGAPGAPIAPSEEKTKEELASFCSKKCYYELASATRAPLTEEEVAAAEQHVSEEVYNKLKQ 1795
Human 2200 V----FVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPG--PLLGVLPVVGVVRPAPPPPPP 2258
| .||...:|:...|.:..| ..|...:..| ..:.::||..::.....|...
Worm 1796 VLTENIVKAVSQGKKPDPQLTSP---------RDTRCMMDEGRRENVTIVPVASLIGAVEAPKEA 1851
Human 2259 PLTLVLSSGPASPPRQA---------IRVKRVSTFSGRSPPAPPPYKAPRLDE----------DG 2304
|.. .:..|:...:| :.:::.......||....|:....||: ||
Worm 1852 PSQ---RAAEAAEDWKAYTKSIWDSFVNIQQQHAHHILSPKIGVPHPPYHLDKRICVFCGGIGDG 1913
Human 2305 EASED-------------------TPQVPGLGSGGFSRVRMKTPTVRGVL--------DLDRPG- 2341
|.:.. :.:|....:||.:.|. |.|| ...|||
Worm 1914 ETTRCGRLISLTEFYWVHVNCALWSAEVFENQTGGLTNVD------RAVLRAAQTACDHCKRPGA 1972
Human 2342 -------------------------------------EPAGEESPGPL----------QERSPLL 2359
:.:.:...|.| .|.:.|.
Worm 1973 SVKCHKMNCGVNYHVLCAMQNNGFFIKDRTFICKQHEKVSNQAIVGRLDALRRIYVKRDENTMLT 2037
Human 2360 PLPEDGPPQVPDGPPDLLLESQWHHYS-GEASSSEEEPPSPDD---KENQ-------APKRTGPH 2413
.|.| :.|||...:....:..|. |..:..:.:.....| ..|. :||.....
Worm 2038 RLFE-----LTDGPTLCMRLGAFTFYKIGSITPKQLKRFHTKDYIFPNNYRITRLFWSPKSHRER 2097
Human 2414 LRFEISSEDG-----FSV----------EAESLEGAWRTLIEKVQEARGHARLRHLSFSG--MSG 2461
:.||...||. |.| :|.|...||:.:.|||.:.|...:...|.|.| :.|
Worm 2098 MMFECIIEDRNNQPIFVVKSLEDPTICYKAVSASKAWQPIYEKVHQLREQQQGDSLKFFGSQICG 2162
Human 2462 ARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEP-PLNPHGAARAEVYLRKCTFDMF- 2524
..|.|::.:|:..:.|.|||......|:.| ||.....|.| ..|..|.||||. |..|....
Worm 2163 ETLFGLNENAITKITESLPGFDTIFTYQHR-HQNSPVLELPLAENLMGCARAEP--RNRTIGQHF 2224
Human 2525 -----------------NFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLE------------- 2559
:.|:||..::...::...| .|:|.:.|||:.
Worm 2225 RTKPQPMGGTHHHIGSASGLSSQATIIASSSSSANE----SLQSRQAATSVTSANSGRTRGVRSY 2285
Human 2560 -------------LPMAM------------------RFRHLKKTSKEAVGVYRSAIHGRGLFCKR 2593
:|..| .::.:::..|:.|.:.||.|.|.||:.|.
Worm 2286 YTEEAAARARAFGIPPEMASLSLRMETTQNAQTAFSAYQKMRREWKDRVYLARSRIAGLGLYAKV 2350
Human 2594 NIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPN 2658
:|..|:.:|||.|.:|||.:.:.||..|..:..|.||||:|:..|:||||.|..||:|||||:||
Worm 2351 DISMGDFIIEYKGEIIRSEVCEVREIRYVAQNRGVYMFRIDEEWVIDATMAGGPARYINHSCDPN 2415
Human 2659 CFSRVIHVEG---QKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2715
|.::::.... :|.|:|.|.|.|...|||||||:|.:|..::|:||.|||..|.:::|
Worm 2416 CSTQILDAGSGAREKKIIITANRPISANEELTYDYQFELEGTTDKIPCLCGAPNCVKWMN 2475
| 
