back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KMT2B and kmt2b

DIOPT Version :9

Sequence 1:	NP_055542.1	Gene:	KMT2B / 9757	HGNCID:	15840	Length:	2715	Species:	Homo sapiens
Sequence 2:	XP_002940678.3	Gene:	kmt2b / 100144721	XenbaseID:	XB-GENE-853845	Length:	2817	Species:	Xenopus tropicalis

Alignment Length:	3133	Identity:	1260/3133 - (40%)
Similarity:	1591/3133 - (50%)	Gaps:	734/3133 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDT 65
            |||||........||.|||||||| ..|..|.|      ||||||..:    .:.........|:
Frog     1 MAAAAASAGPGASGSVRGRFPGRP-WVGRSGSR------AERVRVPFQ----VSAEAACSENPDS 54

Human    66 ALLRLLGLRRGLRRLRRLWAGPRVQRGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDE 130
            |.|::|||.|.|:||:                       ..|     ..|.:|.||:|.||.::|
Frog    55 AQLQILGLHRNLKRLK-----------------------GAC-----GRDSDSGEEDFVGFTAEE 91

Human   131 DVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAP-------TPPK-----TPARKRGE 183
            ....||||.||||.||:.|         .|.|...|...||       .||.     ||
Frog    92 SALGSSLRLALRSNRGKTP---------DPAPTSSLPSAAPPRKPLCSIPPSLRHIFTP------ 141

Human   184 EGTERMVQA-LTEL-------------LRRAQAPQAP-----RSRACEPST----------PRRS 219
               |:.|:. ||:|             :.|.:..:.|     ::...:|||          |.:.
Frog   142 ---EKEVRVHLTQLDPSLFNMAKYSTIITRPKKEEVPIGLERQNSPADPSTGAEHKLYTAEPPKQ 203

Human   220 RGRP--------------------------PGRPAGPCRRKQQAV--VVAEAAVTIPKPEP---- 252
            :|||                          |.:....|..:..|.  ..|.:|.|....|.
Frog   204 KGRPQRARVRTWKARASEAFRHHSQTDHSDPSQEETKCCDEGNATDNCDAPSAATDKTDEQEELN 268

Human   253 ------PPPVVPVKHQTGSWKCKEGPGPG--------PGTPRRGGQSSRGGRGGRGRGRGGGLPF 303
                  ...|:......|:...:||....        |.:|.:...:.|.|:|.....|
Frog   269 DRKRTLTSQVIAPSELEGTLCRREGHASNAQVLEKDLPASPNKACPAFREGQGDTQVPR------ 327

Human   304 VIKFVSRAKKVKMGQLSLGL--------ESGQG---------QG-QHEESWQDVPQRRV----GS 346
             :|:...|...:..:|..|.        ::..|         :| |.:|:....|..|:    ..
Frog   328 -VKWKLWADYKQENELETGASEADVTANDTAYGGNMDLPLPEEGLQSKEALPSGPTDRLLCPEAE 391

Human   347 GQGGSPCWKKQEQKLDD---EEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTP 408
            |...|.|.:::|:...|   ..||.|.:.:...||          .::|..| :.:..|...|
Frog   392 GLQASECLEREERNQSDGCGTGEEHKADIDCGSEG----------LLLPHHE-DSSGFPASVL-- 443

Human   409 PAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKRGRPP 473
             |......|...||:......    ....||.||.....|..:.        |....:.|:.:
Frog   444 -AAEETSVLDVNSTNENAGFI----LAAEPPALPDSSSVPRNKR--------VKKLSNSKKAK-- 493

Human   474 LTPSQRAEREAAR----AGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSA 534
            :..:::||:.||:    ...|......|....      :.|...||::       :..:.||.:|
Frog   494 ILRAKKAEQMAAKRLLAKIKEANIKAQPYMQA------QSSKRTAPRN-------KSNVAPVANA 545

Human   535 RSSRVIKTPRRFMDEDPPKP---------PKVEVSPVLRPPITTSPPVPQE---PAPVPS----- 582
            |.|||||.||||:||....|         |.:..:.:|...:|  .|.|:|   |.|.|:
Frog   546 RPSRVIKAPRRFLDEAQLSPFTENQTKSNPMLHNADILSSSLT--EPEPEEISDPLPSPTDTFFN 608

Human   583 ----------PPRAPTPPSTP-----------VPLP-----EKRRSILREPTFRWTSL---TREL 618
                      ||.:|...|||           |.||     .||::|||.|||.|.|:   .:|.
Frog   609 LFSEDHLCFLPPLSPEAESTPSCPSSASSPTLVSLPPSLSESKRKNILRAPTFCWNSVGTAEQEA 673

Human   619 P--------------PPPPAPP--------PPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKI 661
            |              |..|..|        .|.:|.|.|.|....:|..||||||||||||||||
Frog   674 PSTLCSSRPLFRLQSPASPLEPLQLNLPLSAPSSPPPQPVPKLEPKRSPLLRAPQFTPSEAHLKI 738

Human   662 YESVLTPPPLG-APEAP----------------------EPEPPPADDSPAEPEPRAVG--RTNH 701
            ||||......| .|.:|                      |....||    |:.....||  |.||
Frog   739 YESVSFEDRDGKVPFSPLLSNRQHHTDFTSSATASVCTTETMSAPA----AKQSDLNVGGRRANH 799

Human   702 LSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQLLPQ-------------AL 753
            |::|.|...:..              .:|.:|...:.:|......|:|..             .|
Frog   800 LTIPMFDSTLEK--------------GDGLETNLLVTEPTLKPSDQILSDPVETLNSGYNRIGKL 850

Human   754 PPPQPQLQPPPSP----------QQMPPLEKARIAGVGSL----PLSGVEEKMFSLLKRAKVQLF 804
            .....:|.|..||          ..:.|.:.....|:.|.    .|||.::|:.|||::||:||.
Frog   851 EMGAIKLGPVDSPGVVCKMAIKSPSLSPTDTLGEIGISSAVNDQTLSGTDKKVISLLEKAKLQLI 915

Human   805 KIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIK 869
            :||:|:..::                                           |.:|||||||||
Frog   916 RIDKQKNSEL-------------------------------------------GQDSPVQGPRIK 937

Human   870 HVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLA------TEDTSSASETESVPSRSRRGKVE 928
            |||||.:|||||.|||:|||:||||||||.:|:..|      .|::|||||.||...:.:|.
Frog   938 HVCRHPSVALGQPRAMIPEDIPRLSALPLHEREPPAPSSIAQPEESSSASEPESSTVKQKRA--- 999

Human   929 AAGPGGESEPTGSGGTLAHTPRRSLPSHHGK-KMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGG 992
                               .|.||.|....| ::||.|||.|:|||...|||.|:||.||.||||
Frog  1000 -------------------APVRSKPKPPTKARLRMGRCGTCKGCLVQDDCGKCINCKDKTKFGG 1045

Human   993 PNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREE 1057
            |||||||||:|:||.|.||::||..||||   |...| ..:..|::....|...|.       ||
Frog  1046 PNTKKQCCVFRQCDAILARRLERAGKKGR---KAPAP-PRENLPDSDDNYPDTWRA-------EE 1099

Human  1058 VVAHPGPEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSE-PGGPPAPRRRTPRENELPLPEPEEQ 1121
            ..|:    :.|||.||||:||||:|||.||:|.||:||: ..||...|::|.||::|...|.|||
Frog  1100 TEAN----DPDSLSQRKSSRRCVRQRPFYDLFPDSEDSDYDPGPRVSRKKTRRESDLLPQESEEQ 1160

Human  1122 SRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWL 1186
            |:||:...||:: |:||:..:::        |..||.:||.||.||.:|:||||||||||:||||
Frog  1161 SKPRRTPQQPLI-LRARKGPEQE--------SIMNGGSGKLKSADGTYRLRVDFKEDCDLQNVWL 1216

Human  1187 MGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKF 1251
            |||||||||||..|.::||||||:|.|:|::|||||:|||.|||||:|||||....|||||||||
Frog  1217 MGGLSVLTSVPVNPTLMCLLCASRGRHKLLYCQVCCEPFHRFCLEESERPLPNQEGTWCCRRCKF 1281

Human  1252 CHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDV 1316
            |:|||:||:..|.|||||.|:..||..||||:||.:|.|..:.|.||||:||:|||..|||:.|:
Frog  1282 CNVCGQKGKAKKPLLECELCQTNYHVNCLGPNYPLKAPRSGKGWTCSACIRCRSCGIAPGKDGDL 1346

Human  1317 EWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSG 1381
            |.:.|..||..|:.||:|||:||||.||||:::|||||:|||:||.|:|:||||||||.||:||.
Frog  1347 ELTEDSKLCSECSTLYDKGNFCPICIRCYEESEYESKMIQCAKCDKWIHSKCEGLSDEGYELLSN 1411

Human  1382 LPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPD--GKQLHP 1444
            |||||:|||.||.|.:.|.|:||:...|..||.:||||||:......||.|.||...  |.:...
Frog  1412 LPDSVVYTCPPCLGNSSPIWKEAMLSELTAGLHEVLQGLLALDPAASLLHCAQCSASDGGTKCQH 1476

Human  1445 GPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFD 1509
            |||.||::.|..|||||.||.:|.:::..|:.:..::........|..:|.|.||.:|.:|.||:
Frog  1477 GPCDLQSLRQLLEDGHYSSVSTFNDNVAYIIQKGMKQENCGSGFDGNALKSLYLKSMEKSFSWFN 1541

Human  1510 AHDPKYWRRSTRL-PNGVLPNAVLPPSLDHVYAQWRQQEPETPESG---QPPGDPSAAFQGKDPA 1570
            |.:.::|:.:.:: ..|:|||||||||.||.||.||.::.:.|..|   :....|....:.....
Frog  1542 AEESEHWQTNRKMETKGILPNAVLPPSSDHNYANWRIKKEDPPSKGVVQKATSPPKVKLESDAEP 1606

Human  1571 AFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVAR 1635
            |.....|.|||||||||||.|.|:||||||||||||||:||||||||||||||||||||||||||
Frog  1607 AGEIKTDTRQCALCLKYGDDDPKDAGRLLYIGQNEWTHINCAIWSAEVFEENDGSLKNVHAAVAR 1671

Human  1636 GRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGF 1700
            |||:||:.|.|.|||||||||:|.|||||||||||.|.||||||:||.|||.||||.. |..|.|
Frog  1672 GRQLRCDNCQKIGATVGCCLSTCHSNFHFMCARASRCCFQDDKKMFCSKHTKLLDGTP-VEEDCF 1735

Human  1701 DVLRRVYVDFEGINFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYW 1765
            |||||||||||||:|:||||.|||||.|:::|||::|||||.|:|||..||:::|:|||||||||
Frog  1736 DVLRRVYVDFEGISFRRKFLQGLEPDHIHMMIGSMKIDSLGMLNDLSVTEGKIYPVGYQCSRLYW 1800

Human  1766 STVDARRRCWYRCRILEYRPWGPREEPAHLEAAEENQTIVHSPAPSSEPPGGE---DPPLDTDVL 1827
            ||.||||:|||:||:||:.|......|...|..|:|:||||||.|..:|...|   .|||..|..
Frog  1801 STQDARRQCWYKCRVLEHCPNSGETHPEGGEGQEQNKTIVHSPGPLPDPTEMEAAFSPPLPADTS 1865

Human  1828 VP-GAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSP 1891
            .. |.|          |||:|::.:.   |||||.|||:|.|||||||||||| |..||||||||
Frog  1866 SSCGQP----------PPLQPNTSAT---APRSFIGARMKTPNYSPSRRPLGG-SSRPLPSPGSP 1916

Human  1892 --SSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPT 1954
              |||:|||.||.||:. .|.||:|||      .||||:.:|....||:
Frog  1917 TSSSLSHHILTVSDPEV-TPLRRTRRP------VPPSRFNAPSSTRSPE---------------- 1958

Human  1955 SGELAPPGPAPS-------------PPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEE 2006
              |...|.|.|:             .|.|...|...|    |..:|::|   ..:|||  |...:
Frog  1959 --ETTSPSPLPARPVIRHRATSENEVPTPASCGGASE----VEVMSSSD---GGALLG--PCGAQ 2012

Human  2007 IVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAP-SATPGAPRIEQLDGVDDGTDS 2070
            ::.        |..||||.||.: ..:|.....||||...::. .|:..:..|.||||:.|.|||
Frog  2013 LIV--------GSEGDSSSEEDA-DDQYYGLTRTVVSGDKISSMPASASSVHIRQLDGIHDSTDS 2068

Human  2071 EAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLG-----------GP 2124
            | :..|.|.|    |.|.|              :.|..:|||||:|||||.|           ||
Frog  2069 E-DGSQGPCG----PIGGG--------------KTPSHIPSEIVEFVLKNTGNSESSIQLHHIGP 2114

Human  2125 GDGGAGPREESLP---PAPPLANGS-----QPSQGLTASPADPTRTFAWLPGA--PGVRVLSLGP 2179
            ....|.....|..   .|..|:||:     |||||     ..|.|....|...  |.:.|.:...
Frog  2115 PASVASSSSSSSAQNGDATLLSNGNGAVSRQPSQG-----PPPLRDPPQLQRVCHPLISVPTKNT 2174

Human  2180 APEPP---KPATSKIILVNKLGQVFVKMA-GEGE------------------PVPPPVKQ----- 2217
            ...||   ...|.|:||:||:|||.||:. |..|                  |..|.||.
Frog  2175 YDAPPVSVNVPTPKVILLNKMGQVLVKVENGNAEQPLLRETSKAERVTALALPKLPAVKHVKVAP 2239

Human  2218 -----------PPLPPTISPTAPT-------------SWTL------------------------ 2234
                       .|.|..:||:..|             ||||
Frog  2240 KNAKNPLSGLPHPQPTPLSPSMNTVILQATSSINPGQSWTLSTPVVRVVPMLNVMQGTGQITLGT 2304

Human  2235 -----------PPGPLL-------GVLPVVGVVRPAPP---PPPPPLTLVLSSGPASPPRQAIRV 2278
                       |...||       |||.|...|:|..|   |.|.|... |...|.....|...|
Frog  2305 QALMTPAITGIPQTCLLQNVPINSGVLSVASSVQPQQPQLKPAPQPQAR-LQVQPQLSVLQPTPV 2368

Human  2279 KRVS--TFSGRSPPAPP----PYKAPRLDE-DGEASEDTPQVPGLGSG---------------GF 2321
            |.||  :...:.||.|.    |.|.|:|:: ||....|...:..:.|.               ..
Frog  2369 KVVSLPSLCLKRPPLPSSTCFPVKKPKLEQTDGPKVGDKTDISVISSSVVLSADPASSSVAGTRL 2433

Human  2322 SRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYS 2386
            :|.|:|.|.|:.||||....:.....:.|...:.: |....||...:.|...|.|
Frog  2434 NRARIKAPMVQEVLDLTSLKDEEQSLNDGLFIDLT-LAVKDEDSQEETPVDSPSL---------- 2487

Human  2387 GEASSSEEEPP--------SPDDKENQAPKRTGPHLRFEISSEDGFSVEAESLEGAWRTLIEKVQ 2443
                    .||        :.::|::..|:|.||:|||||:|||||.::|:|.|.||:.::||||
Frog  2488 --------APPLEYIPNFENEEEKKSSVPRRDGPYLRFEITSEDGFYIQADSAEDAWKAVLEKVQ 2544

Human  2444 EARGHARLRHLSFS-GMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPH 2507
            |.||..:|||||.| .|.|.|:.|:.||||:||.|||.||:||:.|||.:|.|...:.|...||.
Frog  2545 ETRGVGKLRHLSLSASMIGTRMFGVQHDAVLFLLEQLTGAERCRGYKFLFHPQEVEEGEISTNPS 2609

Human  2508 GAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKT 2572
            |.||:|||:||.|||||||||||||.|||...|:|||:||||:||||||||:|||||||||||||
Frog  2610 GCARSEVYVRKSTFDMFNFLASQHRTLPEIGPCEEEEEEVQLKSTRRATSLDLPMAMRFRHLKKT 2674

Human  2573 SKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFD 2637
            ||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||:||||
Frog  2675 SKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRIDDFD 2739

Human  2638 VVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLP 2702
            ||||||||||||||||||||||:||||||||||||||||||.|.|||||||||||||||||||||
Frog  2740 VVDATMHGNAARFINHSCEPNCYSRVIHVEGQKHIVIFALRSIYRGEELTYDYKFPIEDASNKLP 2804

Human  2703 CNCGAKRCRRFLN 2715
            ||||||:||||||
Frog  2805 CNCGAKKCRRFLN 2817

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.