Protein Alignment STARD8 and gei-1

DIOPT Version :10

• Sequence 1: XP_011529371.2
• Gene: STARD8 / 9754
• HGNCID: 19161
• Length: 1113
• Species: Homo sapiens
• Sequence 2: NP_497694.3
• Gene: gei-1 / 175436
• WormBaseID: WBGene00001559
• Length: 1510
• Species: Caenorhabditis elegans
• Alignment Length: 1202
• Identity: 315/1202 - (26%)
• Similarity: 488/1202 - (40%)
• Gaps: 256/1202 - (21%)

Human    37 EAEAKRACEWLQATGFPQYVQLFEEGSFPLDIGSVKKNHGFLDEDSLGALCRRLMTLNNCASMKL 101
            |.:|..||.||:..||.:|...||||..|:   ...|:...|:.| |.||.||:..||.|.:||:
 Worm   440 ERDAVDACSWLRKAGFSKYADQFEEGKLPI---VASKDPTLLEAD-LRALNRRIDVLNRCHTMKV 500

Human   102 E-VHFQSKQNEDSEEEEQCTI-------SSHWAF-----QQESKCWS-PMGS------SDLLAPP 146
            : |..:.:.|.:....:...|       |..|.:     ...|..|| |.||      ..|...|
 Worm   501 DSVPMRRRINNEFPRLDPMKIDDNSGYSSDSWRYGSVGGSHHSNTWSRPSGSDHHVYGGSLARMP 565

Human   147 SPGLPATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPT--QGQEGPQDK 209
            :    :|||                  :...:.||       |:...|.:|...  ..|..|
 Worm   566 N----STSS------------------AWHHQMAD-------PTRDSRKVLRTDWYDAQNTP--- 598

Human   210 AKKRHRNRSFLKHLESLR--RKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAKNW 272
              .|.||...|:...|..  .:..|..|:::.:.....:..:.|....||
 Worm   599 --PRGRNNDVLETASSAACVNELNSKLQRSQSERIKDRARAIMKKMDLRS--------------- 646

Human   273 AATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIE--SLCPEDGH 335
                     .|.|      |..:...|...:.||.:: |..| .|....||..|:  |:.||.|.
 Worm   647 ---------TNKR------PKETRGRPAPMNIGDPVL-VSYD-TPKNSIRSHHIDRPSILPERGR 694

Human   336 RLADWQP------GRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGS 394
            :|....|      .:......|||             .|..:.|..|..:.......|...|..|
 Worm   695 QLYPTSPYQAPSRSKSIAQNNRRG-------------GLVFITPTSPNSLDTSFGYSDTNSSVVS 746

Human   395 YAHLDDILQHVWGLQQRVELW----SRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEALSQME 455
             :|..:      |..:|.||.    ||......||.....:......||...:....|.....:|
 Worm   747 -SHRSN------GESRRRELSMPPPSRHRVQMNGPSYPVMDGTLRRREIMPFDSYLYAGNPKMLE 804

Human   456 VPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQEAHS------- 513
                    .:.:....|..|.|       :.:..:..:.|.|........:|...::|
 Worm   805 --------RYDKTYESPRNLIP-------DRMYDDLDDLPLPKSTKTTNSNSTSNSNSLDNKKTD 854

Human   514 ------GGEPTFASSLSVEEGHSISDTV------ASSSELDSSGNSMNEAEAAGPLAGLQASMPR 566
                  .|..|.....::...|:|..||      .::.::|...:|   .|..|..|      ..
 Worm   855 NISMFNDGYYTHEIKTALPRHHNILTTVKPENLKVNTEKIDIISSS---DEPIGRTA------LT 910

Human   567 ERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSES----------------------------LE 603
            :|.|||:|:||:|..........:.|..|..|:.|                            :|
 Worm   911 KRSDSGLGSSLSRSPSGPHTQRIRQSLLPYSNATSSSASAYSCCSWGSSTKLLDEQQPFFTDMVE 975

Human   604 INRQFAGQINL-----LHKGSLLRLTAFMEK--------------YTVPHKQGWVWSMPKFMRRN 649
            :.|.. ..:||     |.|.:.|||::.:|:              ..:|.|.  |||:.:.::|.
 Worm   976 LARSI-DSLNLIEMTRLRKTAFLRLSSILERNIEGKGVGLVDPDQEELPSKH--VWSVQRLIKRM 1037

Human   650 KTPDYRGQH----------VFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKS 704
            |..|  ||.          ||||...:...|||..||:.|.:.|::||:...:.||||||:||||
 Worm  1038 KIND--GQKREKDVDGDGAVFGVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKS 1100

Human   705 RIQNLRQMNETSPDNV-CYEGQS------AYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLP 762
            ||..||.:.|:...|. .:.|::      .:||||||||||||||||:.|.|::..|..|..::|
 Worm  1101 RIAELRSIIESYSGNTDVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVP 1165

Human   763 KDQWLAAAQAATLLLPDENREVLQTLLYFLSDIA-SAEENQMTAGNLAVCLAPSIFHLNVSKKDS 826
            ..:.:.|.|.|.|||||||||.|:|||.||.::: :::.|.|||.||:||..||:|.|..|:.|.
 Worm  1166 DVERITALQYAILLLPDENREALKTLLLFLKEVSRNSQVNNMTAQNLSVCFTPSLFQLGASRLDK 1230

Human   827 PSPRIKSKRSL--IGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQLCSSYSAAELSPP 889
            .:|..:..:::  .|.|..:::.:..|....|:.:|...:.:|.||..    |..|..|.:   .
 Worm  1231 VTPGNRRHKTVGATGLPSEKEMKEARACQLCLTMLIEYVQTVFMVPDG----LDDSMDAED---D 1288

Human   890 GPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMSVPGPQHTELACRKAPDGHPLRLWK 954
            .|.|.||.......     ::.:.:.||:||.::::|.|......:..|::.::..|.|||:.::
 Worm  1289 NPNLTELGLKGPRS-----FLVDRVIDLIRDHSDQWKNWTIEGSFRGIEISSKRPSDSHPLKTFR 1348

Human   955 ASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL-MPGVELYHYVTDSMAPHPCRDFVVLRMW 1018
            ....|.|.|..|:.|:|:||..||..::..:.||.: .|..:::.||.:....||.:|..|.|..
 Worm  1349 VWLNVPAGPKSVMMRLLKERYTWDSSVINWRHLEYVSAPDTDIHQYVVNETIGHPTKDCHVARFH 1413

Human  1019 RSDLP--RGGCLLVSQSLDPEQPVPESGVRALMLTSQYLMEPCGLGRSRLTHICRADLRGRSPDW 1081
            .|.|.  ||.|.:..:|:...:.....||.|.:...::|:||...|:||:.:|.|.||:|||..|
 Worm  1414 SSGLTEIRGACAIAERSVKCTEDQLLGGVSATIFDQRFLIEPVSGGQSRVNYIARVDLKGRSLQW 1478

Human  1082 YNKVFGHLCAMEVAKIRDSFPTLQAAGPETKL 1113
            |||.||.:....:.::|:||......||||.:
 Worm  1479 YNKSFGSIMCRHLDRLRESFHLGDKGGPETNV 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STARD8	XP_011529371.2	SAM_superfamily	41..100	CDD:472832	23/58 (40%)
		RhoGAP	659..873	CDD:470621	92/223 (41%)
		SRPBCC	900..1104	CDD:472699	62/206 (30%)
gei-1	NP_497694.3	SAM_superfamily	444..499	CDD:472832	23/58 (40%)
		RhoGAP_DLC1	1052..1279	CDD:239840	92/230 (40%)
		SRPBCC	1302..1501	CDD:472699	62/203 (31%)