DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZSCAN12 and CG11247

DIOPT Version :9

Sequence 1:	NP_001156863.1	Gene:	ZSCAN12 / 9753	HGNCID:	13172	Length:	611	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	141/494 - (28%)
Similarity:	211/494 - (42%)	Gaps:	103/494 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   106 VQEQHPESGEEVVTVLEDLERELDEPGEQVSVHTGEQEMFLQETVRLRKEGEPSMSLQSMKAQPK 170
            |:.:...|.|:.|::|.|....|..|                ...|....| |:::::..|:
  Fly     2 VRSRRSVSKEDAVSLLTDSGISLSSP----------------PAARESSPG-PTLAIKRRKS--- 46

Human   171 YESPELESQQEQVLDVETGNEYGNLKQEVSEEMEPHGKTSSKFEN----DMSKSARCGETREPEE 231
                .|.|.::..:|               ||.:..|:..||.::    .:.||||.||.
  Fly    47 ----SLASLRDACVD---------------EEEDDGGEQDSKDDDYVQPQLKKSARKGEP----- 87

Human   232 ITEEPSACSREDKQPTCDENGVSLTENSDHTEHQRICPGEESYGCDDCGKAFSQHSHLIEHQRIH 296
                                    .:...|.             |..|.|.|...:.|..|..||
  Fly    88 ------------------------VKRKHHV-------------CSQCSKEFGGKTDLQRHMLIH 115

Human   297 TGDRPYKCEECGKAFRGRTVLIRH-KIIHTGEKPYKCNECGKAFGRWSALNQHQRLHTGEKHYHC 360
            :.:||:||::|||::|....|..| ...|...|.:.|::|.|:|.....|..|.|||:|||.|.|
  Fly   116 SDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPC 180

Human   361 NDCGKAFSQKAGLFHHIKIH--TRDKPYQCTQCNKSFSRRSILTQHQGVHTGAKPYECNECGKAF 423
            :.|.|.|::...|..|:..|  |..:.:.||:|:.|||..:.|..|...|.....:.|:.|...|
  Fly   181 DLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQF 245

Human   424 VYNSSLVSH--QEIHHKEKCYQCKECGKSFS-QSGLIQHQRIHTGEKPYKCDVCEKAFIQRTSLT 485
            ....:|.:|  || |||...::|:.|.|... ...|..|.:.||..|.:.|:||...|.|::...
  Fly   246 ANELALRAHINQE-HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYN 309

Human   486 EHQRIHTGERPYKCDKCGKAFTQRSVLTEHQRIHTGERPYKCDECGN--AFRGITSLIQH-QRIH 547
            .|.|:|||||||:|..|.:.|...|||..|.|.||||:|::|..|.:  ||..:..|..| ::||
  Fly   310 VHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIH 374

Human   548 TGEKPYQCDECGKAFRQRSDLSKHQRIHNRRGTYVCKEC 586
            ..:|||.|:.|...|:.:.:|..|.. |       |.:|
  Fly   375 KQQKPYMCEGCHDFFKIKVELQSHVE-H-------CAKC 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZSCAN12	NP_001156863.1	SCAN	42..152	CDD:128708	8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..175		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..264		12/69 (17%)
		C2H2 Zn finger	248..268	CDD:275368	1/19 (5%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		COG5048	299..579	CDD:227381	104/288 (36%)
		C2H2 Zn finger	304..324	CDD:275368	7/20 (35%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		C2H2 Zn finger	416..436	CDD:275368	7/21 (33%)
		C2H2 Zn finger	444..463	CDD:275368	5/19 (26%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		C2H2 Zn finger	499..519	CDD:275368	8/19 (42%)
		C2H2 Zn finger	527..547	CDD:275368	6/22 (27%)
		C2H2 Zn finger	555..575	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	2/4 (50%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/171 (32%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	63/177 (36%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	7/22 (32%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910