DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZSCAN12 and CG11696

DIOPT Version :9

Sequence 1:	NP_001156863.1	Gene:	ZSCAN12 / 9753	HGNCID:	13172	Length:	611	Species:	Homo sapiens
Sequence 2:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	123/576 - (21%)
Similarity:	222/576 - (38%)	Gaps:	117/576 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    70 LCHQWLRPETHTKEQILELLVLEQFLTILPEELQAWVQEQHPESGEEVVTVLEDLERELDEPGEQ 134
            ||::..|          :|..:|||.:::.|      :::......::.|.|.:|. ||.||...
  Fly    53 LCNRCWR----------QLAEIEQFCSMVAE------KQRSLHRSLQLKTELPELP-ELTEPEPA 100

Human   135 VSVHTGEQEMFLQETVRLRKEGEPSMSLQSMKAQPKYESPELESQ--QEQVLDV-----ETGNEY 192
            :.|...|..:            ||.:|         ||..:::..  .|.|:|.     |..::|
  Fly   101 LVVWNTESPI------------EPKLS---------YEGDDIKDHILCEPVIDALSAGDEKDSDY 144

Human   193 GNL-------KQEVSEEMEP---------------------HGKTSSKFENDMSK--------SA 221
            |:.       :.:..||.||                     |.....|:|....:        |.
  Fly   145 GDTFEPDFEPESQPDEEEEPEPDPVKPRPRGRPRKTALQQTHQIIKRKYEKRKQQNKAKITELSL 209

Human   222 RCGETREPEEITEEPSACSREDKQPTCDEN-----GVSLTENSD----------HTEHQRICPGE 271
            |  |:|..:...:..||.:.:|:....||.     |..||.::|          ..:.:::...:
  Fly   210 R--ESRARQRELKRSSAGAEDDQDGDEDEEDEEDVGGELTPDADEQPKPRGKRGRPKTKKLVTAD 272

Human   272 ESYGCDDCGKAFSQHSHLIEHQRIHTGDRPYKCEECGKAFRGRTVLIRH-KIIHTGEKPYKCNEC 335
            ::   ||..:...:.|.:.|.......:....|..|.........|.|| ::.|......||  |
  Fly   273 DN---DDTSEVPVKRSSIKEMDDYIAANVKLDCAICAAPLEDFNDLKRHFRVEHDCTGYVKC--C 332

Human   336 GKAFGRWSALNQHQRLHTGEKHYHCNDCGKAF-SQKAGLFHHIKIHTRDKP--YQCTQCNKSFSR 397
            ...:.:.:....|...|...:::.|..|.|.| ::.:.:.|.::.|::.:.  :||..|...|::
  Fly   333 NNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVMHMLRFHSQQQELVHQCAICEARFAK 397

Human   398 RSILTQHQGVHTGA-KPYECNECGKAFVYNSSLVSHQEIHHKEKCYQ--CKECGKSF-SQSGLIQ 458
            :.:||.|...|.|. :|..|:.|.|.|.....|.:|.:..|......  |..||..| |::..:.
  Fly   398 KFLLTMHLKGHKGTERPEVCDTCSKTFRTKFELSAHVKRMHAADFTPIICDICGTHFRSKANFLI 462

Human   459 HQRIHTGEKP---YKCDVCEKAFIQRTSLTEHQRIH---TGERPYKCDKCGKAFTQRSVLTEHQR 517
            |::....:.|   .:|.:|.:......||.:|...|   .|:..|:|..|....:.|:.|:.|.|
  Fly   463 HKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDRDGDTKYRCLLCNAEKSSRAALSSHMR 527

Human   518 IHTGERPYKCDECGNAFRGITSLIQHQRIHTGEKPYQCDECGKAFRQRSDLSKHQR 573
            .|...:.:||..|...|:...:|.:|...|||...|||..|.:.|:..:::..|::
  Fly   528 YHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLYQCQFCTRTFKSHANMHNHKK 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZSCAN12	NP_001156863.1	SCAN	42..152	CDD:128708	17/81 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..175		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..264		20/109 (18%)
		C2H2 Zn finger	248..268	CDD:275368	6/34 (18%)
		C2H2 Zn finger	276..296	CDD:275368	4/19 (21%)
		COG5048	299..579	CDD:227381	71/289 (25%)
		C2H2 Zn finger	304..324	CDD:275368	5/20 (25%)
		C2H2 Zn finger	332..352	CDD:275368	3/19 (16%)
		C2H2 Zn finger	360..380	CDD:275368	5/20 (25%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		C2H2 Zn finger	444..463	CDD:275368	6/19 (32%)
		C2H2 Zn finger	471..491	CDD:275368	5/19 (26%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..575	CDD:275368	4/19 (21%)
		C2H2 Zn finger	583..603	CDD:275368
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	8/40 (20%)
		C2H2 Zn finger	332..349	CDD:275368	2/16 (13%)
		C2H2 Zn finger	357..378	CDD:275368	5/20 (25%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	447..465	CDD:275368	6/17 (35%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..583	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910