Protein Alignment SLK and KIC1

DIOPT Version :10

• Sequence 1: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Sequence 2: NP_011970.1
• Gene: KIC1 / 856502
• SGDID: S000001144
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 853
• Identity: 215/853 - (25%)
• Similarity: 357/853 - (41%)
• Gaps: 146/853 - (17%)

Human    35 EIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSE-EELEDYMVEIDILASCDH-PNIVKLLDA 97
            |:||.   |.||.|||..|.:|..:.|.||::..|: :|:||...||..|||... .||.:...:
Yeast    27 EVIGR---GKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGS 88

Human    98 FYYENNLWILIEFCAGGAVDAVMLELERP--LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGN 160
            :..:.:|||::|.||||::.:::    ||  :.|..|.|:.::.|.||..:|.:.:||||:||.|
Yeast    89 YLKDTSLWIIMEHCAGGSLRSLL----RPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAAN 149

Human   161 ILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL 225
            :|.|.:|::||.||||:|:..:|..||.:..||||||||||:|    :...||.|.|:||||||.
Yeast   150 VLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIM----EGVYYDTKVDIWSLGITT 210

Human   226 IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHP 290
            .|:|...||:.::..:|.:..|.||:||.|...| :|::.|:|:..||:::...|.:...||:..
Yeast   211 YEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADDLLKSK 274

Human   291 FVTVDSNKP---IRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRA------SSDLSIA 346
            |:......|   ::|||:.......:.....|.|....|.|.|.|..|.|.:      .:..|||
Yeast   275 FIRAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEAPKPSQNGGGDEAQKSIA 339

Human   347 SSEEDKLSQNACILESVSE-KTERSNSEDKLNSK--ILNEKPTTDEPEKAVEDINEHITDAQLEA 408
            |::.:        ::.|:| ..|.....|.|:|.  |:......|   ...||.||..| ||.:.
Yeast   340 SNDNE--------IKRVNEGDVEMKWDFDSLSSSDYIIENNINLD---ALAEDNNEWAT-AQHDL 392

Human   409 MTELH--DRTAVIKENEREKRPKL-------ENLPDTEDQETV----DINSVSEGKENNIMITLE 460
            ....:  :.:..........||.:       :..|.|..|.:.    ..|:.:..|..:.|:...
Yeast   393 FNYAYPDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNAPVTNNYTNSKYPSKMVAGT 457

Human   461 TN---------IEHNLKSEEEKDQEKQQMFE-NKLIKSEEIKDTILQTVDLVSQETGEKEANIQA 515
            ||         :..:.:.|.:..::..::|| |::|                   |.|.:.|.:|
Yeast   458 TNTSGTHTAGPMTSSKRLESKAPKQLLELFEDNEII-------------------TAENDVNTEA 503

Human   516 VDSEVGLTKEDTQEKLGEDDKTQKDVI-SNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVE 579
            ......::      .|...:.::.|.| |.:::|.|......:...:...|:.:...:.....:.
Yeast   504 PKISKSIS------SLNAGNSSRDDFIPSISNEVNGNINNNKMRPHLPPLSSGNNYYSQSTPALP 562

Human   580 VGQKLINKPMVGPEAGGTKEVPIKEIVEMNE------IEEGKNKEQAINSSENIMDINEEPGTTE 638
            :.|...||...||...|....|....:|:.|      :....:.:..:..|..........||..
Yeast   563 LLQTKFNKTSKGPPTSGLTTAPTSIEIEIPEELPNSALPTPASADPVLIPSTKARSSTVTAGTPS 627

Human   639 GEEITESSSTEEMEVRSVVAD----------TDQKALGSEVQDASKVTT----------QIDKEK 683
            .....:..|...:..|..|::          |:|| |||.|...|.:::          ..|.|.
Yeast   628 SSSSIQYKSPSNVPRRLTVSNNRPEHCPSTITNQK-LGSAVASNSGISSTPNNSNNYNNNTDSEN 691

Human   684 ----------KEIPVSIKKEPEVTVV-----SQPTEPQPVLIPSININSDSGENKEEIGSLSKTE 733
                      ....:.|.....||.:     |.|:.|...:..|.| ...:|...:.||..|...
Yeast   692 SRGSSGSNTANSTQMGITNPGNVTKLSTHKASSPSRPLFGVGTSPN-RKPAGSPTQNIGHNSTHT 755

Human   734 TILPPESENPKENDNDS-----------GTGSTADTSS--IDLNLSISSFLSKTKDSGSISLQET 785
            .:.||.:..|..|..|:           .:.||.:|.|  ...||:.|::.|..|:...:: .:.
Yeast   756 NLAPPPTMKPMANSKDNKDILLQPLNSIPSSSTLNTISGNSSNNLTSSNYFSNEKEGSRVN-GDF 819

Human   786 RRQKKTLK 793
            :|....||
Yeast   820 KRNNPNLK 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	108/280 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		12/47 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539		1/19 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760		36/192 (19%)
		PKK	852..990	CDD:463600
		PKK	1020..1160	CDD:463600
KIC1	NP_011970.1	STKc_NAK1_like	21..295	CDD:270822	108/279 (39%)