DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLK and BCK1

DIOPT Version :9

Sequence 1:	NP_055535.2	Gene:	SLK / 9748	HGNCID:	11088	Length:	1235	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	371	Identity:	112/371 - (30%)
Similarity:	169/371 - (45%)	Gaps:	74/371 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    14 SEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT---KSEEE--- 72
            |:.:.|::..:|.::           :|.|:||.||...|..|..:.|.|.::.   .|:.|
Yeast  1166 SKGEYKEFAWMKGEM-----------IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAIL 1219

Human    73 --LEDYMVEIDILASCDHPNIVKLLDAFYYENNLW-ILIEFCAGGAVDAVMLELERPLTESQIQV 134
              :|....|:..|...||.|||:.| .|..:||:: :.:|:.|||:|.: ::.:.....|..|:.
Yeast  1220 STVEALRSEVSTLKDLDHLNIVQYL-GFENKNNIYSLFLEYVAGGSVGS-LIRMYGRFDEPLIKH 1282

Human   135 VCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRD-SFIGTPYWMA 198
            :..|.|..|.|||...|:|||:||.|:|...||..|::|||:|.|:.......| :..||.:|||
Yeast  1283 LTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMA 1347

Human   199 PEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSE--PP----TLAQ 257
            ||:|  :|.:.  |..|.|:||||..::||...:.|...|..:..:.||.||:  ||    ||..
Yeast  1348 PEMV--DTKQG--YSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPL 1408

Human   258 PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEED 322
            .|:...||.|   .|.|.|.:.|.|.::||.|||                              .
Yeast  1409 ISQIGRNFLD---ACFEINPEKRPTANELLSHPF------------------------------S 1440

Human   323 EEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTE 368
            |..||.|.        .|:.|:......|||:.:...:.|...|||
Yeast  1441 EVNETFNF--------KSTRLAKFIKSNDKLNSSKLRITSQENKTE 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	96/296 (32%)
		S_TKc	34..292	CDD:214567	95/273 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..393		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..441
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..760
		PKK	852..990	CDD:289257
		PKK	1020..1160	CDD:289257
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	97/316 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910