Protein Alignment SLK and slka

DIOPT Version :10

• Sequence 1: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Sequence 2: XP_005156928.1
• Gene: slka / 568838
• ZFINID: ZDB-GENE-050411-66
• Length: 1232
• Species: Danio rerio
• Alignment Length: 1301
• Identity: 816/1301 - (62%)
• Similarity: 960/1301 - (73%)
• Gaps: 135/1301 - (10%)

Human     1 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVI 65
            |||||||||||||:||||||||||.||:||||||||:|||||||||||||||||:|.:|||||||
Zfish     1 MSFFNFRKIFKLGTEKKKKQYEHVNRDVNPEDFWEIVGELGDGAFGKVYKAQNKQTGILAAAKVI 65

Human    66 DTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTES 130
            |||:|||||||||||||||||||..|||||||||||:.||||||||||||||||||||||||||.
Zfish    66 DTKTEEELEDYMVEIDILASCDHQYIVKLLDAFYYESKLWILIEFCAGGAVDAVMLELERPLTEP 130

Human   131 QIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPY 195
            ||:|||||:|:||.|||:||||||||||||||||.||:|||||||||||||:|:|||||||||||
Zfish   131 QIRVVCKQSLEALVYLHENKIIHRDLKAGNILFTSDGNIKLADFGVSAKNTKTLQRRDSFIGTPY 195

Human   196 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
            ||||||||||||||||||||||:||||:||||:|:||||:||:||||||||||||||||||.|||
Zfish   196 WMAPEVVMCETSKDRPYDYKADIWSLGVTLIELAQIEPPNHEMNPMRVLLKIAKSEPPTLASPSR 260

Human   261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT--VDSNKPIRELIAEAKAEVTEEVEDGKEEDE 323
            ||..|.|||:|.|:||||.||:..||||||||:  || |||:|||||||||||.||.|:||||:|
Zfish   261 WSPEFSDFLRKALDKNVDNRWSALQLLQHPFVSSLVD-NKPLRELIAEAKAEVFEEFEEGKEEEE 324

Human   324 EEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTD 388
            |||.|....:...|||.||.|:.|||:::.:||...||||   |||:..|.|      .|....|
Zfish   325 EEEPEPQSAVQGHKRALSDTSVGSSEDERQNQNTPTLESV---TERAEPERK------PEDRACD 380

Human   389 EPEKAVEDINE--HITDAQL-------EAMTELHDRTAVIKENEREKRP--------KLENLPDT 436
            :....|.|.||  |:.|.::       .:..||.....:|.:.|....|        ...|.|..
Zfish   381 KTSAMVVDANESNHLEDGKIVEANVSDTSAEELRSGDELISKQEESPMPVSTEGGVTDQPNAPTA 445

Human   437 EDQETVDINSVSE--GKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTV 499
            .|....:|.:|||  |:|..    .|..:|..|:.:||:.:|     .|...|::.|.|.
Zfish   446 NDTNLQEIVTVSEETGEEEK----KEVKVEEKLEKKEEESEE-----INMKAKAQSITDE----- 496

Human   500 DLVSQETGEKEANIQAVDSEV-----GLTKEDTQEKLGEDDKTQKDVISNTSDVIG-------TC 552
                    |||..:.:.::|.     |:|:|...|.:...:||: |.:.|..:|.|       |.
Zfish   497 --------EKEHALPSDEAEPKNKSDGVTEEAITELIEVTEKTE-DKLENEEEVHGKEPEEDKTV 552

Human   553 EAADV-AQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKN 616
            .:||| .:|:.|.:  :|..:...|.|:..|         |||  :.:|..:|:.|..|...|.:
Zfish   553 TSADVPTEKLKEQT--ETLPDVSTEEVKKEQ---------PEA--SPDVSTEEVKEQPETLPGAS 604

Human   617 KEQAIN---------SSENIMDINEEP-----GTTE--GEEITESS---STEEMEVRSVVAD--- 659
            .|:...         |||   ::.::|     |:||  .||..|:|   |.|..|.:.|..|
Zfish   605 SEEVKKEQPETLPDASSE---EVKKQPEPSPKGSTEEVKEEQPETSPEVSKEVKEDQLVPEDQNK 666

Human   660 TDQKALGSEVQDASKVTTQIDKEKKEIPVSI---KKEPEVTVVSQPTEPQPVLIPSININSDSGE 721
            |::||   |:.:...|....|....::||.:   .||.||:...:|.|              :.|
Zfish   667 TEEKA---EITEPRGVDVVEDISLSKVPVVVINGVKEEEVSATEEPAE--------------APE 714

Human   722 NKEEI-------GSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGS 779
            ::.||       .|...|..:..|::|  ||.|:|||:.|.|||:|||:||||||||||:|: ||
Zfish   715 DRPEIQEAPAMPESDHNTVDVAKPDAE--KEKDSDSGSSSAADTNSIDINLSISSFLSKSKE-GS 776

Human   780 ISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRA 844
            :|:|:.:||||||||||||:||||||||||||||||:|:|:|||||||||||||||.||||||||
Zfish   777 VSIQDIKRQKKTLKKTRKFLVDGVEVSVTTSKIVTDNDTKSEELRFLRRQELRELRLLQKEEQRA 841

Human   845 QQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKG 909
            ||||::|||||:||:||||||||..||||||||:||||||||||||||||:|||||||||||||.
Zfish   842 QQQLSNKLQQQKEQLFRRFEQEMSGKKRQYDQEVENLEKQQKQTIERLEQDHTNRLRDEAKRIKA 906

Human   910 EQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGS 974
            ||:|||||||||||||||||..||..:||.:|||||||.||:||..||.:||||:|:|||||||:
Zfish   907 EQDKELSKFQNMLKNRKKEVKQEVGLSPKHMRKELMKRLKEDLAAIQHGEEQEFLQRQQQELDGA 971

Human   975 LKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLL 1039
            |||||||.|.|:|.|||:|||:|||||||||||:|||||||||||||||||||||||||||||||
Zfish   972 LKKIIQQHKLEIATIERDCLNHKQQLMRAREAAMWELEERHLQEKHQLLKQQLKDQYFMQRHQLL 1036

Human  1040 KRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDK 1104
            |||:||.||||.||||||||:||||.|||||||||||||||||||||||||||..|.||:|||:|
Zfish  1037 KRHDKEMEQMQGYNQRLIEEMKNRQAQERARLPKIQRSEAKTRMAMFKKSLRITGTGTPEQDREK 1101

Human  1105 IKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDE 1169
            |||||.||:|||||||:.||||||||||||||||::|:|||.|:||||||||:||||||||||||
Zfish  1102 IKQFAVQEDKRQKNERLHQHQKHENQMRDLQLQCDSNIRELQQMQNEKCHLLIEHETQKLKELDE 1166

Human  1170 EHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTG 1234
            ||||||||||||||||||.|||||.||||||||||||:|||||||||||||:||||||||:||:|
Zfish  1167 EHSQELKEWREKLRPRKKALEEEFTRKLQEQEVFFKMSGESECLNPSTQSRVSKFYPIPSVHSSG 1231

Human  1235 S 1235
            |
Zfish  1232 S 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	240/282 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		24/41 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393		8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760		49/178 (28%)
		PKK	852..990	CDD:463600	109/137 (80%)
		PKK	1020..1160	CDD:463600	119/139 (86%)
slka	XP_005156928.1	STKc_SLK	28..310	CDD:270811	240/282 (85%)
		PTZ00121	<350..949	CDD:173412	283/666 (42%)
		PKK	849..987	CDD:463600	109/137 (80%)
		PKK	1017..1157	CDD:463600	119/139 (86%)