Protein Alignment SLK and Slk

DIOPT Version :10

• Sequence 1: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Sequence 2: XP_006231620.1
• Gene: Slk / 54308
• RGDID: 3780
• Length: 1234
• Species: Rattus norvegicus
• Alignment Length: 1243
• Identity: 1019/1243 - (81%)
• Similarity: 1113/1243 - (89%)
• Gaps: 17/1243 - (1%)

Human     1 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVI 65
            |||||||||||||||||||||||||||||||:||||||||||||||||||||||||:||||||||
  Rat     1 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVI 65

Human    66 DTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTES 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 DTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTES 130

Human   131 QIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPY 195
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 QIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPY 195

Human   196 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260

Human   261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEE 325
            |||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||:::
  Rat   261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKEEDDDD 325

Human   326 ETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEP 390
            |||::|||||:|||||||||||||||||||||||||||||:||.:.|.||.::|:|:||||.:.|
  Rat   326 ETESALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEHNTSGDKFSNKVLSEKPTPEGP 390

Human   391 EKAVEDINEHITDAQLEAMTELHDRTAVIKENERE-KRPKLENLPDTEDQETVDINSVSEGKENN 454
            |||| |::....|..||.:.|.:|:.....||.|| ||||||:.||||||:|||:|.|.||.::|
  Rat   391 EKAV-DVDGPANDVNLETVAEPNDQAVGFHENGREKKRPKLESQPDTEDQQTVDVNLVGEGNDSN 454

Human   455 IMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSE 519
            |:| ||||.: .||.||::::|.|::.||||.:||||||..:||:||||||||||||:.||:|:|
  Rat   455 IVI-LETNTD-CLKPEEDRNEENQEIIENKLTQSEEIKDIHIQTMDLVSQETGEKEADFQAIDNE 517

Human   520 VGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKL 584
            ||.|||:||||||:||||||.|||:.|..:||.||....||..|.| :|.:...|:|..|..|.|
  Rat   518 VGFTKEETQEKLGKDDKTQKVVISDISSEVGTDEAPGDTQKAAEQS-QDAEGGAGEEAPEPAQTL 581

Human   585 INKPMVGPEAGGTKEVP-------IKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEI 642
            ..|...||||.|.:|.|       .|::.:.:.:.||:.  |..::||:.....|||.|.|.:::
  Rat   582 TEKATEGPEAHGAEEEPRSGERVEDKQLEQQSAVCEGEG--QVTSTSESTRATTEEPETDEVDQV 644

Human   643 TESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQP 707
            :||:|.||:| |..|...:::||||:.:.|::|..:.::..:|:|  ||.||:....|||:||.|
  Rat   645 SESNSIEELE-RLGVTGAEEQALGSKGEAATEVDLEREENAQELP--IKAEPQAPAASQPSEPPP 706

Human   708 VLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLS 772
            ||||||||:|::.|||.|:|:|.|.|||||||.||.|.||.|||||||.:.||.|||||||||||
  Rat   707 VLIPSINIHSENTENKGEMGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISSFLS 771

Human   773 KTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFL 837
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
  Rat   772 KTKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRLL 836

Human   838 QKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRD 902
            |||||:||||||.|||||||||||||||||:||||||||||||||||||||||||||||||||||
  Rat   837 QKEEQKAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRD 901

Human   903 EAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQ 967
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
  Rat   902 EAKRIKGEQEKELSKFQNMLRNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQ 966

Human   968 QQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYF 1032
            ||||||:||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
  Rat   967 QQELDGALKKIIQQQKAELANIERECLNNKQQLLRAREAAIWELEERHLQEKHQLLKQQLKDQYF 1031

Human  1033 MQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTAT 1097
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1032 IQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTAT 1096

Human  1098 PDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQ 1162
            |||||:|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||
  Rat  1097 PDQDREKIKQFAAQEEKRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQ 1161

Human  1163 KLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPI 1227
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
  Rat  1162 KLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPI 1226

Human  1228 PSLHSTGS 1235
            |:||||||
  Rat  1227 PTLHSTGS 1234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	276/280 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		35/41 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393		16/29 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441		16/20 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539		16/19 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760		71/146 (49%)
		PKK	852..990	CDD:463600	134/137 (98%)
		PKK	1020..1160	CDD:463600	136/139 (98%)
Slk	XP_006231620.1	STKc_SLK	28..309	CDD:270811	276/280 (99%)
		PKK	851..989	CDD:463600	134/137 (98%)
		PKK	1019..1159	CDD:463600	136/139 (98%)