Protein Alignment SLK and Slik

DIOPT Version :10

• Sequence 1: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Sequence 2: NP_726441.1
• Gene: Slik / 37893
• FlyBaseID: FBgn0035001
• Length: 1703
• Species: Drosophila melanogaster
• Alignment Length: 1377
• Identity: 472/1377 - (34%)
• Similarity: 707/1377 - (51%)
• Gaps: 226/1377 - (16%)

Human     1 MSFF-NFRKIFKL--GSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAA 62
            |||. |.:|:|.|  |..|||:.|.::|.|.:|.:|||::|||||||||||||||:||....|||
  Fly     1 MSFITNLKKVFHLGGGEAKKKRLYNNIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAA 65

Human    63 KVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPL 127
            |:...:.||.|.|:|||||||:...|||||:|.:||..::.||:|||:|.|||:|::|:|||:||
  Fly    66 KMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPL 130

Human   128 TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIG 192
            ||.||..|||...:.|.:||.||:|||||||||:|.|::|.:|||||||||||..|:|:.|:|||
  Fly   131 TEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIG 195

Human   193 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQ 257
            ||||||||:|:|||.:|.|||:|.|:|||||||||:|::|||:.|::||||||||.|||||.|.|
  Fly   196 TPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQ 260

Human   258 PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV--TVDSNKPIRELIAEAKAEVTEEVEDGKE 320
            |||||..|.|||||.|.|:...|.||..|:||.|:  .:|: |||::|:.|.||||.|||.|
  Fly   261 PSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDA-KPIKDLLLEYKAEVVEEVVD--- 321

Human   321 EDEEEETENS-LPIPASKRASSDLSIASSEEDKL-SQNACILESVSEKTERSNS------EDKLN 377
             ||.||..|| |.:...   ....|:.|.:.||| .....||....|:::.|:|      .....
  Fly   322 -DETEEPRNSALQLDLD---DDSASLQSQDIDKLPGTPTSILRDAKEQSQPSSSLPIAAAATAAA 382

Human   378 SKILNEKPTT-DEPEKAVEDINEHITDAQLEAMTELHDRTAV----IKENEREKRPKLENLPDTE 437
            :.....|.|| |.|        .|..|...||..:....|.|    ...:::...|:::..|...
  Fly   383 AATTTTKATTPDRP--------NHTKDDNAEAAAQQPPHTKVPAPAPPSSQQTPPPQVQQPPTPP 439

Human   438 DQETV--------DINSVSEGKENNIMITLETNIEHNLKS------------EEEKDQEKQQMFE 482
            .|.|.        |:.:|:|..|..     |::.:|.:|.            ...|.........
  Fly   440 AQPTAAVLQKKPEDVAAVAETSEKT-----ESDKKHFVKKGKAPPPPSPLGLANAKPAASDSQTS 499

Human   483 NKLIKSEEIKDTILQTVDL-VSQE-----------TGEKEANIQAVDSEVG--------LTKEDT 527
            .|.:.:.|....:...::: :.||           |.....::|:|.|...        |:...:
  Fly   500 PKKLATPEPTSPVTTAIEVAIGQEAMEPKPQPPSPTASSIVSVQSVASSSSSGSVSNAVLSSSTS 564

Human   528 QEKLGEDDKT---------------------------------------------QKDVISNTSD 547
            ...:..|..|                                             |.:||..::|
  Fly   565 LITINSDPPTPHHHQPLPPQPQHLILPNSLESVSQITVVTSTHPPVIIDNSVMPPQNEVIIVSND 629

Human   548 VIGTCEAADVAQKVD----EDSAEDTQSNDGKE---VVEVGQK--LINKPMVGPEAGGTKEVPIK 603
            :..:....:.:...|    :||..|..:...|:   ::.|.:.  ::..|...|:...|
  Fly   630 MNKSTHLHESSTDDDFPSLDDSLGDATTPPHKQSSMILAVNEPAGVVPAPPSQPQTSST------ 688

Human   604 EIVEMNEIEEGK---------NKEQAINS---------SENIMDINEEPGTTEGEE-ITESSSTE 649
              |...:::|.:         :.:.|.|:         |:::||.:.....|.|:| :....|:.
  Fly   689 --VHARKLDESEVLIVSPSYADDDSAYNTASGSHSHDHSDHLMDTSHVSVVTVGDEGVKVKDSSN 751

Human   650 EMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEV------------------ 696
            |:..|      ....:|...:|.:.:..:..:||:....|:.:...|
  Fly   752 ELVKR------QPNGVGIVPEDVNIIVNRFKQEKRSPDSSLSENGSVRGRRGIEVLVGGSGGSDV 810

Human   697 ----TVVSQPTE-----------PQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKEN 746
                |..||.:.           |...|:|....:..:..|.|.|.  .:.|.::.|::..|...
  Fly   811 DSIGTNTSQESRHETDHNNKQQYPAAALMPPPPPSLTNNHNHETID--EEEEVVIRPKARVPAVV 873

Human   747 DNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSK 811
            .:.:..|.|.:                     .|.|:..|  |||.|:||||.:|||:::.|||:
  Fly   874 KSANAQGLTKE---------------------EIELRNLR--KKTRKRTRKFEIDGVQMTTTTSR 915

Human   812 IV--TDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQY 874
            ::  .|.:.:..:....|:||||||:.|||:|::.|.:|:.|.||.:||..||||||..|.::.|
  Fly   916 VIYGDDENGRIYDDHDFRKQELRELKLLQKQEKKQQTELHLKEQQAKEQQDRRFEQERSSLEKTY 980

Human   875 DQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKE 939
            :.:::.|.:|.||.:|:.||...|.||..:|||:.|||:||..|:..||...:.:..||:..||:
  Fly   981 EADMDMLARQHKQLVEKTEQTQENELRSSSKRIRSEQEQELKIFRENLKQEIRLLKQEVDLFPKD 1045

Human   940 LRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAR 1004
            .||:..|:|:..:......:|:.|:...::..:..|:::.::.:..||.|.|..|..||..||.|
  Fly  1046 KRKDEFKQRRSAMELDHEEKERAFLDSLKERHELLLRRLSEKHRDHLATINRNFLQQKQNAMRTR 1110

Human  1005 EAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERA 1069
            ||.:|||||:.|.|:|||.|:.:|:..||||||::.|||||.:|::|..||..|::..:||.|:.
  Fly  1111 EALLWELEEKQLHERHQLSKRHVKELCFMQRHQMIIRHEKELDQVKRMLQRKEEDMVKKQTMEKR 1175

Human  1070 RLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDL 1134
            .|||..|:|.|.|..||::||||::...|:.:||::|:|..||:||...|......||:.|:.:|
  Fly  1176 ALPKRIRAERKARDLMFRESLRISTNLDPEIERDRLKKFQEQEKKRYMQEERRFEVKHQKQLEEL 1240

Human  1135 QLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQE 1199
            :...|:.::||.||||||...|||||..||.|:||....||:||||:|.|||:.|..:....:.:
  Fly  1241 RATRESAIKELEQLQNEKRRALVEHEHSKLSEIDERLKGELREWREQLVPRKQELNRQIKLAIDQ 1305

Human  1200 QEVFFKMTGESE 1211
            .|..|.:....|
  Fly  1306 HEKRFGLVTNRE 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	174/282 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		16/42 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539		3/72 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760		32/198 (16%)
		PKK	852..990	CDD:463600	46/137 (34%)
		PKK	1020..1160	CDD:463600	63/139 (45%)
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	173/279 (62%)
		PKK	958..1095	CDD:463600	46/136 (34%)
		PKK	1126..1266	CDD:463600	63/139 (45%)