Protein Alignment SLK and nak1

DIOPT Version :10

• Sequence 1: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Sequence 2: NP_596023.1
• Gene: nak1 / 2539963
• PomBaseID: SPBC17F3.02
• Length: 652
• Species: Schizosaccharomyces pombe
• Alignment Length: 749
• Identity: 179/749 - (23%)
• Similarity: 302/749 - (40%)
• Gaps: 188/749 - (25%)

Human    40 LGDGAFGKVYKAQNKETSVLAAAKV--IDTKSEEELEDYMVEIDILA---SCDHPNIVKLLDAFY 99
            :|.|::|.||:.....|....|.|:  :|| .|:|:.|...|:.:|:   ..|..||:|...::.
pombe    16 VGRGSYGAVYRGICNLTKETVAIKILNLDT-DEDEVSDIQKEVAVLSELKQSDVENIIKYHGSYL 79

Human   100 YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT 164
            ...||||::::|.||:|..:|  ...|::|..|.::.::||.||.::|...|||||:||.|||.:
pombe    80 VGTNLWIIMDYCHGGSVRTLM--EAGPISEPCISLILRETLQALKFIHHAGIIHRDIKAANILVS 142

Human   165 LDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKD-RPYDYKADVWSLGITLIEM 228
            :.|::||.||||:|:.....::|.:||||||||||||:     :| :.|:..||:||||||..|:
pombe   143 MSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVI-----RDGQEYNVMADIWSLGITAYEI 202

Human   229 AEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT 293
            |...|||.:.:|.|.:..||.:.||.|  ...:|:..|:|:..||:.....|..:|:||:..|:.
pombe   203 ATGSPPHAKEDPFRAVYLIAHTAPPRL--NGNFSALLKEFIASCLQDVPQRRLDSSELLKSKFIK 265

Human   294 VDSNKPIRELIAEAKAEVT--------------EEVEDGKEEDEEEETENSLPIPASKRASSDLS 344
            ..|...|.||....|...|              ||.:||.:.|:|          .|..|:||
pombe   266 QYSRMSISELTNVVKRYDTWQAAGGIPQTLLLGEEADDGSDPDQE----------TSDTAASD-- 318

Human   345 IASSEEDKLSQNACILESV----SEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQ 405
             ...|...:.|....:.|:    :..|..:.|...:...::.:..|..||..:
pombe   319 -DGWEFGTIKQGQSNVSSITGTSTSTTTAATSSTTVTGTVIPKSSTVHEPPSS------------ 370

Human   406 LEAMTELHDRTAVIKENE--REKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLK 468
                .:.|....:.|:::  .:..|.......|||         |:|:.:...|.|.:....||.
pombe   371 ----NDSHPLLQLFKDSKISDDDSPSNAEGASTED---------SKGEVSYSQIELPSLDSSNLS 422

Human   469 SEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGE 533
            |::...|.|.                             .|:|  :..|..||.|:.::
pombe   423 SKKSTIQSKH-----------------------------TKQA--EDYDLFVGRTRSNS------ 450

Human   534 DDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTK 598
              ||..|                  |.:........|    ::...:|::            |..
pombe   451 --KTSSD------------------QSIKRPLPRVVQ----RQKTSLGKR------------GIS 479

Human   599 EVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQK 663
            ..|:|..:.|....:.:::..::.:.|.:....|.|..      ..|:..:.:||...::....|
pombe   480 MSPMKPGLRMPSSFDLQSRSISMGAFEQLSTPLEAPAH------KHSAVLQPLEVNRSISIPPPK 538

Human   664 ALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEP---------------QPVLIPSI 713
            ::...:         :.|...|   |....|:::..|...:|               .|.:.|..
pombe   539 SISPSI---------LHKPSLE---SASSTPKISSCSSTPKPFNSKLRAHLPPLSIGSPAVQPLA 591

Human   714 NINSDS----GENKEEI----GSLSKTETILPPE 739
            |.|.||    |.|.|..    |::...:::|..|
pombe   592 NDNYDSLGVRGLNMELFNDYPGNMHNIKSVLSLE 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	103/274 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539		5/19 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760		25/150 (17%)
		PKK	852..990	CDD:463600
		PKK	1020..1160	CDD:463600
nak1	NP_596023.1	Protein Kinases, catalytic domain	8..282	CDD:473864	104/275 (38%)