Protein Alignment SLK and slk

DIOPT Version :10

• Sequence 1: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Sequence 2: XP_031762309.1
• Gene: slk / 100145483
• XenbaseID: XB-GENE-877088
• Length: 1338
• Species: Xenopus tropicalis
• Alignment Length: 1358
• Identity: 841/1358 - (61%)
• Similarity: 990/1358 - (72%)
• Gaps: 143/1358 - (10%)

Human     1 MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVI 65
            |||||||||||||.:||||||||||||.|||::|||:|||||||||||||||||||.:|||||||
 Frog     1 MSFFNFRKIFKLGGDKKKKQYEHVKRDQNPEEYWEIVGELGDGAFGKVYKAQNKETGILAAAKVI 65

Human    66 DTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTES 130
            |||||:||||||||||||||||||:|||||||||||||||||||||||||||||||||||.|||.
 Frog    66 DTKSEDELEDYMVEIDILASCDHPHIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERALTEP 130

Human   131 QIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPY 195
            ||:|||||||:||.|||::|||||||||||||.|||||:||||||||||||||:|||||||||||
 Frog   131 QIRVVCKQTLEALVYLHESKIIHRDLKAGNILLTLDGDVKLADFGVSAKNTRTLQRRDSFIGTPY 195

Human   196 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260
            ||||||||||||||||||:||||||||:||||||:||||||||||||||||||||||||||||||
 Frog   196 WMAPEVVMCETSKDRPYDFKADVWSLGVTLIEMAQIEPPHHELNPMRVLLKIAKSEPPTLAQPSR 260

Human   261 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT-VDSNKPIRELIAEAKAEVTEEVEDGKEEDEE 324
            ||..|.|:|||||||||||||||:||||||||: |:||||:|||||||||||.|||||.||::||
 Frog   261 WSPEFNDYLKKCLEKNVDARWTTTQLLQHPFVSVVNSNKPLRELIAEAKAEVLEEVEDAKEDEEE 325

Human   325 EETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDE 389
            :|.|:|||:| .|||||||||||.|:||||||...||.|||:...:..|:::..:....|...:|
 Frog   326 DEGESSLPVP-DKRASSDLSIASLEDDKLSQNTSTLEPVSEQVVPTVVENQVIDQESEAKVKKEE 389

Human   390 PEK--AVEDINEHIT------DAQLEAMTELHDRTAVIKENEREKRPKLENLPD----------- 435
            .:|  .|:.:.:..:      ||..:.:::......|.|:...::..|..:...
 Frog   390 GDKKIIVDQVGKDASADQVGKDASADQVSKDASADQVGKDASADQVGKDASADQVGKDASADQVG 454

Human   436 ---------------------TEDQETVDINSVSEGKENNI----------MITLETNIEHNLK- 468
                                 :.||...|.::...||..::          .:..:.:.:...|
 Frog   455 KDASADQVGKDASADQVGKDASADQVGKDASADQVGKGASVDQVGKGASADQVGKDASADQVGKG 519

Human   469 -SEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLG 532
             |.::..::..::.:..|:..:.:.|...:..|.|.::  ::|:||..|:..:     |:|:|..
 Frog   520 ASADQVGKDASEVVQEILVADKALSDGDNRIQDTVKEK--KEESNIPVVEPAI-----DSQKKES 577

Human   533 ED------DKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLIN----- 586
            ||      :.|.|.:|...|.  ...:.||.....|..||.|||.....|.:.:.:.|.|
 Frog   578 EDISLLPEEGTGKTIIETESQ--HKTDQADPLLADDVPSAIDTQKEGKPENLNITENLENQSDEV 640

Human   587 ------KPMVG---------PEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEP-- 634
                  |..:.         |:..||.||.:.||.: :|::  .|......:.|::::..|.|
 Frog   641 SENGFIKESIEVQNERTKNIPKENGTIEVALNEIAD-SEVQ--SNHGITFGNPEDVLENGEMPSK 702

Human   635 ---GTTEG-------------EEITESS---STEEMEVRSVVADT-----DQKALGSE------- 668
               |..:|             |:||.:|   :.|.:|....:.|.     |.:.:.||
 Frog   703 DSHGNHKGSDPLNEGICSDKKEDITVASTALANEVLEPAGQINDVLPSEGDAQVMNSEESKETNK 767

Human   669 ------VQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPT-----EPQPVLIPSININSDSGEN 722
                  |...:|:...:.....::..|......|:|.::.:     |.|| .:|||::  .|.:.
 Frog   768 DIHDNNVDVLNKIPDSVSHLNTDLEQSCDNTVNVSVAAESSSATVHERQP-CVPSISV--ISADQ 829

Human   723 KEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRR 787
            ||...|:|..|.    ....|:..|:|||.|||.|:.|:||||||||||||.|:|||:|:|:.||
 Frog   830 KENTSSISTAEA----SKSEPEHTDSDSGMGSTNDSGSMDLNLSISSFLSKGKESGSLSVQDNRR 890

Human   788 QKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKL 852
            ||||||||||||||||||||||||||||:|||:||:||||||||||||.||||||||||.|::||
 Frog   891 QKKTLKKTRKFIVDGVEVSVTTSKIVTDNDSKSEEMRFLRRQELRELRLLQKEEQRAQQLLSNKL 955

Human   853 QQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSK 917
            .|||||||:||||||.||||||||:||||||||||||||||||||.|||||||||||||:||.||
 Frog   956 LQQREQIFKRFEQEMTSKKRQYDQDIENLEKQQKQTIERLEQEHTTRLRDEAKRIKGEQDKEYSK 1020

Human   918 FQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQ 982
            |||:|||||||||||||||.||||||||||:|||||||||||||||||||||||||||||||.||
 Frog  1021 FQNVLKNRKKEVINEVEKAAKELRKELMKRKKEELAQSQHAQEQEFVQKQQQELDGSLKKIIHQQ 1085

Human   983 KAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETE 1047
            |.|||||||:|||:|||||||||||||||||||||||||||||||||||||||||||||||||.|
 Frog  1086 KTELANIERDCLNHKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKEME 1150

Human  1048 QMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQE 1112
            ||||||||||||||||||||||||||||||:||||||||||||||||:.:|:|||:|||||..||
 Frog  1151 QMQRYNQRLIEELKNRQTQERARLPKIQRSDAKTRMAMFKKSLRINSSGSPEQDREKIKQFGLQE 1215

Human  1113 EKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKE 1177
            :|||||||:|||||||||||||||||:||||||.||||||||||:||||||||||||||:.||||
 Frog  1216 DKRQKNERLAQHQKHENQMRDLQLQCDANVRELQQLQNEKCHLLIEHETQKLKELDEEHAVELKE 1280

Human  1178 WREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS 1235
            ||||||||||.||||||||||||||||||:||||||||:|||||||||||||:|||.|
 Frog  1281 WREKLRPRKKALEEEFARKLQEQEVFFKMSGESECLNPTTQSRISKFYPIPSMHSTSS 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	251/281 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		30/41 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441		3/51 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760		42/190 (22%)
		PKK	852..990	CDD:463600	125/137 (91%)
		PKK	1020..1160	CDD:463600	125/139 (90%)
slk	XP_031762309.1	STKc_SLK	28..310	CDD:270811	251/281 (89%)
		PKK	955..1093	CDD:463600	125/137 (91%)
		PKK	1123..1263	CDD:463600	125/139 (90%)