Protein Alignment SETD1A and SET1

DIOPT Version :10

• Sequence 1: NP_055527.1
• Gene: SETD1A / 9739
• HGNCID: 29010
• Length: 1707
• Species: Homo sapiens
• Sequence 2: NP_011987.1
• Gene: SET1 / 856519
• SGDID: S000001161
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 437
• Identity: 153/437 - (35%)
• Similarity: 212/437 - (48%)
• Gaps: 111/437 - (25%)

Human  1355 QQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPP-------------- 1405
            ::..||.|.......||||||:.|....|:.| .....|...|..:...|.
Yeast   671 KEHDEEDENMTSSSSEEEEEEAPDKKFKSESE-PTTPESDHLHGIKPLVPDQNGSSDVLDASSMY 734

Human  1406 -------PPPPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDMSYLR-----------------LT 1446
                   |.|..||..|:  .::.|.....|:.|:..|.|||..|:                 |.
Yeast   735 KPTATEIPEPVYPPEEYD--LKYSQTLSSMDLQNAIKDEEDMLILKQLLSTYTPTVTPETSAALE 797

Human  1447 YE------RLLQQTSGADW---LNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSA-RSEGYYP 1501
            |:      ::|::...:||   ||.|.:                    ..|.|.||: ::||:..
Yeast   798 YKIWQSRRKVLEEEKASDWQIELNGTLF--------------------DSELQPGSSFKAEGFRK 842

Human  1502 ISKKEKDKYL--------------------DVCPVSARQLEGVDTQGTNRVLSE------RRSEQ 1540
            |:.|.|..||                    :..|...::.|..:.:.::.|..|      .|:..
Yeast   843 IADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASN 907

Human  1541 RRL-------LSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYV 1598
            ||.       .:||||    :|:||.||||..|||.:.|.||.||.|||:|::.|||.||:||||
Yeast   908 RRFQQDIEAQKAAIGT----ESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYV 968

Human  1599 GQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQ 1663
            |:.|||.||:||||||::.|||||||||||.:|:|||||.|.:||||||||.|||.||:|.:..:
Yeast   969 GERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGR 1033

Human  1664 KKIVIYSKQPIGVDEEITYDYKFPLE---DNKIPCLCGTESCRGSLN 1707
            ::||||:.:.|...||:||||||..|   :.::|||||..:|:|.||
Yeast  1034 RRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFLN 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SETD1A	NP_055527.1	Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068	60..89
		RRM_Set1A	92..186	CDD:409964
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..308
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..363
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..486
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..655
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..854
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..1251
		PRK12323	<1070..>1130	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1264..1293
		HCFC1-binding motif (HBM)	1299..1303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1307..1417		20/82 (24%)
		Interaction with CFP1	1415..1450		11/57 (19%)
		N-SET	1425..1562	CDD:463344	41/196 (21%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332	1450..1537		21/116 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1472..1499		5/27 (19%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483	1492..1497		2/5 (40%)
		RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827	1537..1542		1/4 (25%)
		SET_SETD1	1556..1703	CDD:380946	90/149 (60%)
SET1	NP_011987.1	AF-4	<11..>136	CDD:461550
		RRM_scSet1p_like	246..360	CDD:409743
		SET_assoc	422..486	CDD:432058
		N-SET	763..932	CDD:463344	41/192 (21%)
		SET_SET1	926..1076	CDD:380998	90/149 (60%)