DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SETD1A and ash1

DIOPT Version :9

Sequence 1:NP_055527.1 Gene:SETD1A / 9739 HGNCID:29010 Length:1707 Species:Homo sapiens
Sequence 2:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster


Alignment Length:1828 Identity:360/1828 - (19%)
Similarity:575/1828 - (31%) Gaps:619/1828 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   191 QTVPTGGKAL-SEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQ 254
            |......|.| :::.|.||:..|..:|....||.:.:..:.                |.||..|.
  Fly     5 QNETAAAKVLETQRAQESGSENEETDSITDQSSQSKSIKSA----------------TQFSVQRS 53

Human   255 DT----------------------PSSFGQFTPQSSQGTPYTSRGS----TPYSQDSAYSSSTTS 293
            ||                      |.|....|..:..|.......:    ....:....|||..|
  Fly    54 DTDGLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCSEAKNRAVSKKVKVKRKKLASSSGIS 118

Human   294 TSFKPRRSENSYQDAFSRRHFSAS------SASTTASTAIAATTAATASSSASSSSLSSSSSSSS 352
            .|.|..:|:.|...|||    |.|      ......:..:..:....|:.|||..:|....|||.
  Fly   119 KSDKVSKSKKSQISAFS----SDSEDDLPLKVHQQRAPRVLLSAIIQAAQSASKPTLDIGISSSD 179

Human   353 SSSSSQFRS------SDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENT---------- 401
            :...:..::      ||........|:.:..:..:.|..::|..:    .|.|.|          
  Fly   180 NELPNLVQAAIKRVESDTEDTTVEGSFRKAAKDKNLPQYQSTLLQ----DFMEKTQMLGQTVNAK 240

Human   402 -AERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASP 465
             ||............:.:.|..:..||   :...|..|.||..|.....|.:...:.|:    |.
  Fly   241 LAEEKVAKAKEETLVQTAVPRKRRGRP---KKVVPTVPAPGNSGPAINESADSGVISTT----ST 298

Human   466 ARSGSPAPETTNE------SVPFAQHSS-------LDSRI---EMLL-------KEQRSKFSFLA 507
            .:|.:|:|:..||      |:|.|..|.       ||.|:   |.:|       :.|.:|.:..:
  Fly   299 TQSTTPSPKMQNENAVPTGSLPIASSSKPKIDMAYLDKRMYATERVLYPPPRSKRRQNNKKTACS 363

Human   508 SDTEEE----------EENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSG---EP 559
            |..:||          :.|....|.:...|:...:|:....|:         .|....||   :.
  Fly   364 SSNKEELQLDPLWREIDVNKKFRLRSMSVGAASGTGASTTICS---------KVLAAKSGYVSDY 419

Human   560 GATRESPKANGQN-----------------------QASPC------------------------ 577
            |:.|....::..|                       :|..|                        
  Fly   420 GSVRHQRSSHNHNSGYKSDASCKSRYSTKSCMSRRSRAKSCGYRSDCKESGKSGLRMRRKRRASM 484

Human   578 ---SSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQP-AYLLPPR- 637
               ||.|| .:.|.|                         ...||.|.||....:. .|:..|. 
  Fly   485 LLKSSADD-TVEDQD-------------------------ILQLAGLSLGQSSEESNEYISKPSL 523

Human   638 ---PDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGL 699
               |......:|       ..|..:|.:.:...|.|:.....|.:|      ::::...|:    
  Fly   524 KSLPTTSASKKY-------GEINRYVTTGQYFGRGGSLSATNPDNF------ISKMMNQRK---- 571

Human   700 IAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSV 764
                             ..|.|.:::..:.              ||.:       :|..:.||.|
  Fly   572 -----------------ETPAPSKSSCKIK--------------SRRS-------SAASMCSSYV 598

Human   765 SGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWES 829
            ||.............:..|:|       .:.:.|:.|::.|.....:|..::       |.....
  Fly   599 SGVSRMRRRHRRKSFSHNKSL-------NIDSKLLTEIEIITSTFNSRCRIQ-------DDRLTG 649

Human   830 KEEKAKPFQNAAKQQAK-------------------------EEDKEKTKLKEPGLLSLVDW--- 866
            ...|.|...:|.|.||.                         :...:|.||.||    |||:   
  Fly   650 SSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEP----LVDFAML 710

Human   867 -AKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKE 930
             |.:.||..      |||                   .|..:.::|.:.|  ...|...|:..|.
  Fly   711 SASASGTPN------GSG-------------------SSNGNTKRRHKKS--QSNDSSSPDDHKL 748

Human   931 AGEPGR----PGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDRE 991
            ..:...    ||.:||   .|.....||      |::|...|:..::........:........:
  Fly   749 PLKKRHYLLTPGERPP---AEVAFANGK------LNAEAWAAAAAAAKSTASTKSQAQFNARSVK 804

Human   992 EAVDTTKKE-----TEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSS 1051
            .|:...|:.     |.||......|:|..:..:      :|:|.|..:....|.||..|......
  Fly   805 SALTPKKRHLLEQPTSVSGAGSSASNSPLRIVV------DNNSISGGKLLDISPSSLCSLKQQRR 863

Human  1052 SSSSSSSESSSEDEEEEERPAALPSASPPP--------REVPVP---------TPAPVEVPV--- 1096
            ..::....|:::|..:.:.||   .:.|||        .|:.:|         |.|.||.|:   
  Fly   864 GGAAKQKVSAAKDLVQLQSPA---GSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSA 925

Human  1097 ------PERVAGSPVTP-----------LPEQEASPARPAGPT---------EESPPSAPLRPPE 1135
                  .::..|..|..           |..:.....|...||         .|...:|.:...|
  Fly   926 LDIKEDTKKEVGQRVVETLLHKTGGNLLLKRKRKKINRTGFPTVRRKKRKVSVEQQTTAVIDEHE 990

Human  1136 PPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP--PATPPQA-----KFPG 1193
            |...       ||:.|...:         |:|.|.:.:.|..||.||  ....|||     .|..
  Fly   991 PEFD-------PDDEPLQSL---------RETRSSNNVNVQAAPNPPLDCERVPQAGEARETFVA 1039

Human  1194 PASRKAPR----GVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLA 1254
            ..::||||    .:||..|             |:..:| ||.| |.:.:..|:.||.|.....  
  Fly  1040 RTNQKAPRLSVVALERLQR-------------PQTPAR-GRPR-GRKPKNREQAEAAPQPPPK-- 1087

Human  1255 VLADLALTPA-RRG-LPALPAVEDSEATETSDEAERPRPLLSHILLEHNYAL--AVKP------- 1308
              ::..:.|| :|| .|..|.:|:...|        |.|......:|.|..|  .:.|       
  Fly  1088 --SEPEIRPAKKRGRQPKQPVLEEPPPT--------PPPQQKKNKMEPNIRLPDGIDPNTNFSCK 1142

Human  1309 ------------TPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAE---EPKPQQLQQQR 1358
                        |.|... :|.:||         ..:|:  .||:.|::.|   |.:.::|....
  Fly  1143 IRLKRRKNLEAGTQPKKE-KPVQPV---------TVEEI--PPEIPVSQEEIDAEAEAKRLDSIP 1195

Human  1359 EEGE----EEGEEEGEEEEEESSDSSSSSDGEGALRRRS-----------LRSHARRRRPPPP-- 1406
            .|.:    .|....|.::....|:||.......:||:.|           ..:|.::...|||  
  Fly  1196 TEHDPLPASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAK 1260

Human  1407 -----------------PPPPPPRAYEPRSEFEQMTILYDIW----NSGLDSEDMSYLRLTYERL 1450
                             ||||....|..|:|.: ..:.||||    ||.|.:.::.         
  Fly  1261 VNKKPGLEEQVGPASLLPPPPYCEKYLRRTEMD-FELPYDIWWAYTNSKLPTRNVV--------- 1315

Human  1451 LQQTSGADWLNDTHWVHHTI-TNLTTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVC 1514
                        ..|.:..| ||:..  ...||.....:|.|.:.:::|       || ..||.|
  Fly  1316 ------------PSWNYRKIRTNVYA--ESVRPNLAGFDHPTCNCKNQG-------EK-SCLDNC 1358

Human  1515 PVSARQLEGVDTQGTNRVLSERRSEQR--RLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRI 1577
               ..::...:...:|....|:...|:  |...|.|....|.:|                     
  Fly  1359 ---LNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVERFMTAD--------------------- 1399

Human  1578 HEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYL-------FRVDHDTIIDA 1635
            ..||:....|||....::||||:.:       .||.:.|. :.|.||       ..:|...:||.
  Fly  1400 KGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQR-MASIYLNDTHHYCLHLDGGLVIDG 1456

Human  1636 TKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF----PLEDNKIPCL 1696
            .:.|:..||:||.|.|||..:..::....::|:::|:.|...||:||||.|    |.|..  ||.
  Fly  1457 QRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ--PCR 1519

Human  1697 CGTESCRG 1704
            |.|..|||
  Fly  1520 CNTPQCRG 1527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SETD1ANP_055527.1 RRM_Set1A 92..186 CDD:240992
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..308 27/140 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..363 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..486 26/121 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..655 31/216 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..854 6/44 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..1251 86/425 (20%)
DNA_pol3_delta2 <1070..>1130 CDD:331068 19/105 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1293 9/30 (30%)
HCFC1-binding motif (HBM) 1299..1303 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1417 31/165 (19%)
Interaction with CFP1 1415..1450 10/38 (26%)
N-SET 1425..1562 CDD:314603 29/143 (20%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332 1450..1537 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1472..1499 5/26 (19%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1492..1497 0/4 (0%)
SET 1568..1691 CDD:214614 39/133 (29%)
PostSET 1691..1707 CDD:214703 7/14 (50%)
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 12/58 (21%)
SET 1392..1512 CDD:214614 39/148 (26%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.