DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD1A and Setd1a

DIOPT Version :10

Sequence 1:	NP_055527.1	Gene:	SETD1A / 9739	HGNCID:	29010	Length:	1707	Species:	Homo sapiens
Sequence 2:	NP_001414023.1	Gene:	Setd1a / 309001	RGDID:	1311624	Length:	1717	Species:	Rattus norvegicus

Alignment Length:	1724	Identity:	1551/1724 - (89%)
Similarity:	1594/1724 - (92%)	Gaps:	24/1724 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDLQDPRC 65
            |||||||||||||||||||||||||||||||||||||||||||||||||:||||.||||||||||
  Rat     1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVSDSKYTPVEDLQDPRC 65

Human    66 HVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPR 130
            |||||.|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
  Rat    66 HVRSKTRDFSLPVPKFKLDEFYIGQVPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPR 130

Human   131 TRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPT 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 TRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPT 195

Human   196 GGKALSEKFQG-SGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSS 259
            ||||||||||| |||.|||.|:|||||||||||.||||..|||||||||||||:|||||||||||
  Rat   196 GGKALSEKFQGSSGATTETTEARRRSSSDTAAYSAGTTVGGTPGNGTPCSQDTNFSSSRQDTPSS 260

Human   260 FGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTAS 324
            ||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||..|.:
  Rat   261 FGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDSFSRRHFSASSAPATTA 325

Human   325 TAIAATTAAT-ASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRAT 388
            ||.:||.||| ||||:||||.|||||||||||:||||.||::|||||||||||||||||||||||
  Rat   326 TATSATAAATVASSSSSSSSSSSSSSSSSSSSASQFRGSDSSYPAYYESWNRYQRHTSYPPRRAT 390

Human   389 REEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGG----------G 443
            ||:|.||||||||||||||||||||.|||:|.||||||||||||||||||||||          |
  Rat   391 REDPSGAPFAENTAERFPPSYTSYLAPEPNRSTDQDYRPPASEAPPPEPPEPGGGSGGGGGGGSG 455

Human   444 GGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLAS 508
            ||||.|||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 GGGGAPSPEREEARTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLAS 520

Human   509 DTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQ 573
            ||||||||||...||||.|.|||||:|||||||||||||||||||||||||||.|||||||||||
  Rat   521 DTEEEEENSSAGPGARDAGGEVPSGAGHGPCTPPPAPANFEDVAPTGSGEPGAARESPKANGQNQ 585

Human   574 ASPCSSGDDMEISDDDRGGSPPPAPTPPQQ-PPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPR 637
            |||||||:|||||||||||||||||||||| |||||||||||||||||||||||||||||||||.
  Rat   586 ASPCSSGEDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPH 650

Human   638 PDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAA 702
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
  Rat   651 PDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAA 715

Human   703 SAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGE 767
            |||||||||||||||||||||||||||||||.|||||||||||||||||:|||||||||||||||
  Rat   716 SAGPPGGAFGEAFLPFPPPQEAAYGLPYALYTQGQEGRGAYSREAYHLPLPMAAEPLPSSSVSGE 780

Human   768 EARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEE 832
            |||||.|||||:||.|.||:|||||||||.|||||||||||||||||||||||||||||||||||
  Rat   781 EARLPHREEAEIAESKALPSAGTVGRVLATLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEE 845

Human   833 KAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKR 897
            ||||||||||||||||||||.||||||:|||||||||||.|||||||||||||||||||||||||
  Rat   846 KAKPFQNAAKQQAKEEDKEKMKLKEPGMLSLVDWAKSGGITGIEAFAFGSGLRGALRLPSFKVKR 910

Human   898 KEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALD 962
            |||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   911 KEPSEISEASEEKRPRPSTPAEEDEDDPEREKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALD 975

Human   963 SEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGEN 1027
            ||||||||||||||||:|||||||||:||||||.||||.|.||||||:.||||:||||||||||:
  Rat   976 SEGEEASQESSSEKDEDDDEEDEEDEEREEAVDATKKEAEASDGEDEDGDSSSQCSLYADSDGED 1040

Human  1028 DSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPV 1092
            .|||||||.|||||.||||||||||||.|||       ||||:.|.:|||||||||||.|.|||.
  Rat  1041 GSTSDSESGSSSSSPSSSSSSSSSSSSESSS-------EEEEQSAVIPSASPPPREVPEPLPAPD 1098

Human  1093 EVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPL 1157
            |.|..:||..|||.||||:|.:..:||||.||.||:.|..|||||||||.|.||.||||||||||
  Rat  1099 EKPETDRVVDSPVMPLPEKETTSTQPAGPAEEPPPNIPQPPPEPPAGPPDPPPRLDERPSSPIPL 1163

Human  1158 LPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWP 1222
            |||||||||||||||.|..|.|||..|:|.|||.|||.|||.||.||||||||||||||||||||
  Rat  1164 LPPPKKRRKTVSFSATEEAPVPEPSTASPLQAKSPGPVSRKVPRVVERTIRNLPLDHASLVKSWP 1228

Human  1223 EEVSRGGRSRAGGRGRLTEEEEA-EPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEA 1286
            |||:||||:|||||.|.|||||| |.|||||||||||||||||||||.|:|..:|||||||||||
  Rat  1229 EEVARGGRNRAGGRVRSTEEEEATESGTEVDLAVLADLALTPARRGLAAIPTGDDSEATETSDEA 1293

Human  1287 ERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKP 1351
            |||.|||||||||||||||:||.|..||.||.||.||.||||||||||||||||||||||||||.
  Rat  1294 ERPSPLLSHILLEHNYALAIKPPPTTPAPRPLEPAPALAALFSSPADEVLEAPEVVVAEAEEPKQ 1358

Human  1352 QQLQQQREEGEEEGEEEGEEEEEESSD---SSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPR 1413
            ...|||..|.|.|.|||.||||.|||:   ||||||.|||:||||||||.||||||.|||||||.
  Rat  1359 PLQQQQHPEQEGEDEEEDEEEESESSESSSSSSSSDEEGAIRRRSLRSHTRRRRPPLPPPPPPPP 1423

Human  1414 AYEPRSEFEQMTILYDIWNSGLDSEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKR 1478
            ::|||||||||||||||||||||.||||||||||||||||||||||||||||||||||||:||||
  Rat  1424 SFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITNLSTPKR 1488

Human  1479 KRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRL 1543
            ||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||
  Rat  1489 KRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQPEGVDTQGTNRVLSERRSEQRRL 1553

Human  1544 LSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVAD 1608
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1554 LSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVAD 1618

Human  1609 MREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQP 1673
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1619 MREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQP 1683

Human  1674 IGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN 1707
            ||||||||||||||||||||||||||||||||||
  Rat  1684 IGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN 1717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SETD1A	NP_055527.1	Interaction with WDR82. /evidence=ECO:0000269\|PubMed:37030068	60..89		27/28 (96%)
		RRM_Set1A	92..186	CDD:409964	93/93 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..308		106/114 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..363		26/32 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..486		97/114 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..655		139/149 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..854		19/19 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..1251		292/360 (81%)
		PRK12323	<1070..>1130	CDD:481241	36/59 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1264..1293		22/28 (79%)
		HCFC1-binding motif (HBM)	1299..1303		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1417		83/112 (74%)
		Interaction with CFP1	1415..1450		32/34 (94%)
		N-SET	1425..1562	CDD:463344	133/136 (98%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269\|PubMed:17998332	1450..1537		84/86 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1472..1499		25/26 (96%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	1492..1497		4/4 (100%)
		RxxxRR motif. /evidence=ECO:0000250\|UniProtKB:P38827	1537..1542		4/4 (100%)
		SET_SETD1	1556..1703	CDD:380946	146/146 (100%)
Setd1a	NP_001414023.1	None

Return to query results.
Submit another query.

DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD1A and Setd1a

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.