DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD1A and Setd1a

DIOPT Version :9

Sequence 1:	NP_055527.1	Gene:	SETD1A / 9739	HGNCID:	29010	Length:	1707	Species:	Homo sapiens
Sequence 2:	XP_038957149.1	Gene:	Setd1a / 309001	RGDID:	1311624	Length:	1723	Species:	Rattus norvegicus

Alignment Length:	1730	Identity:	1551/1730 - (89%)
Similarity:	1594/1730 - (92%)	Gaps:	30/1730 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDLQDPRC 65
            |||||||||||||||||||||||||||||||||||||||||||||||||:||||.||||||||||
  Rat     1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVSDSKYTPVEDLQDPRC 65

Human    66 HVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPR 130
            |||||.|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
  Rat    66 HVRSKTRDFSLPVPKFKLDEFYIGQVPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPR 130

Human   131 TRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPT 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 TRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPT 195

Human   196 GGKALSEKFQG-SGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSS 259
            ||||||||||| |||.|||.|:|||||||||||.||||..|||||||||||||:|||||||||||
  Rat   196 GGKALSEKFQGSSGATTETTEARRRSSSDTAAYSAGTTVGGTPGNGTPCSQDTNFSSSRQDTPSS 260

Human   260 FGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTAS 324
            ||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||..|.:
  Rat   261 FGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDSFSRRHFSASSAPATTA 325

Human   325 TAIAATTAAT-ASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRAT 388
            ||.:||.||| ||||:||||.|||||||||||:||||.||::|||||||||||||||||||||||
  Rat   326 TATSATAAATVASSSSSSSSSSSSSSSSSSSSASQFRGSDSSYPAYYESWNRYQRHTSYPPRRAT 390

Human   389 REEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGG----------G 443
            ||:|.||||||||||||||||||||.|||:|.||||||||||||||||||||||          |
  Rat   391 REDPSGAPFAENTAERFPPSYTSYLAPEPNRSTDQDYRPPASEAPPPEPPEPGGGSGGGGGGGSG 455

Human   444 GGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLAS 508
            ||||.|||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 GGGGAPSPEREEARTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLAS 520

Human   509 DTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQ 573
            ||||||||||...||||.|.|||||:|||||||||||||||||||||||||||.|||||||||||
  Rat   521 DTEEEEENSSAGPGARDAGGEVPSGAGHGPCTPPPAPANFEDVAPTGSGEPGAARESPKANGQNQ 585

Human   574 ASPCSSGDDMEISDDDRGGSPPPAPTPPQQ-PPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPR 637
            |||||||:|||||||||||||||||||||| |||||||||||||||||||||||||||||||||.
  Rat   586 ASPCSSGEDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPH 650

Human   638 PDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAA 702
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
  Rat   651 PDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLTAA 715

Human   703 SAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGE 767
            |||||||||||||||||||||||||||||||.|||||||||||||||||:|||||||||||||||
  Rat   716 SAGPPGGAFGEAFLPFPPPQEAAYGLPYALYTQGQEGRGAYSREAYHLPLPMAAEPLPSSSVSGE 780

Human   768 EARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEE 832
            |||||.|||||:||.|.||:|||||||||.|||||||||||||||||||||||||||||||||||
  Rat   781 EARLPHREEAEIAESKALPSAGTVGRVLATLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEE 845

Human   833 KAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKR 897
            ||||||||||||||||||||.||||||:|||||||||||.|||||||||||||||||||||||||
  Rat   846 KAKPFQNAAKQQAKEEDKEKMKLKEPGMLSLVDWAKSGGITGIEAFAFGSGLRGALRLPSFKVKR 910

Human   898 KEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALD 962
            |||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   911 KEPSEISEASEEKRPRPSTPAEEDEDDPEREKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALD 975

Human   963 SEGEEASQESSSE------KDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYA 1021
            |||||||||||||      |||:|||||||||:||||||.||||.|.||||||:.||||:|||||
  Rat   976 SEGEEASQESSSEKFVLFLKDEDDDEEDEEDEEREEAVDATKKEAEASDGEDEDGDSSSQCSLYA 1040

Human  1022 DSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPV 1086
            |||||:.|||||||.|||||.||||||||||||.|||       ||||:.|.:|||||||||||.
  Rat  1041 DSDGEDGSTSDSESGSSSSSPSSSSSSSSSSSSESSS-------EEEEQSAVIPSASPPPREVPE 1098

Human  1087 PTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERP 1151
            |.|||.|.|..:||..|||.||||:|.:..:||||.||.||:.|..|||||||||.|.||.||||
  Rat  1099 PLPAPDEKPETDRVVDSPVMPLPEKETTSTQPAGPAEEPPPNIPQPPPEPPAGPPDPPPRLDERP 1163

Human  1152 SSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHAS 1216
            |||||||||||||||||||||.|..|.|||..|:|.|||.|||.|||.||.||||||||||||||
  Rat  1164 SSPIPLLPPPKKRRKTVSFSATEEAPVPEPSTASPLQAKSPGPVSRKVPRVVERTIRNLPLDHAS 1228

Human  1217 LVKSWPEEVSRGGRSRAGGRGRLTEEEEA-EPGTEVDLAVLADLALTPARRGLPALPAVEDSEAT 1280
            |||||||||:||||:|||||.|.|||||| |.|||||||||||||||||||||.|:|..:|||||
  Rat  1229 LVKSWPEEVARGGRNRAGGRVRSTEEEEATESGTEVDLAVLADLALTPARRGLAAIPTGDDSEAT 1293

Human  1281 ETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAE 1345
            |||||||||.|||||||||||||||:||.|..||.||.||.||.|||||||||||||||||||||
  Rat  1294 ETSDEAERPSPLLSHILLEHNYALAIKPPPTTPAPRPLEPAPALAALFSSPADEVLEAPEVVVAE 1358

Human  1346 AEEPKPQQLQQQREEGEEEGEEEGEEEEEESSD---SSSSSDGEGALRRRSLRSHARRRRPPPPP 1407
            |||||....|||..|.|.|.|||.||||.|||:   ||||||.|||:||||||||.||||||.||
  Rat  1359 AEEPKQPLQQQQHPEQEGEDEEEDEEEESESSESSSSSSSSDEEGAIRRRSLRSHTRRRRPPLPP 1423

Human  1408 PPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITN 1472
            |||||.::|||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
  Rat  1424 PPPPPPSFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITN 1488

Human  1473 LTTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERR 1537
            |:||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
  Rat  1489 LSTPKRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQPEGVDTQGTNRVLSERR 1553

Human  1538 SEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNI 1602
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1554 SEQRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNI 1618

Human  1603 RQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIV 1667
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1619 RQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIV 1683

Human  1668 IYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN 1707
            ||||||||||||||||||||||||||||||||||||||||
  Rat  1684 IYSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN 1723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SETD1A	NP_055527.1	RRM_Set1A	92..186	CDD:240992	93/93 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..308		106/114 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..363		26/32 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..486		97/114 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..655		139/149 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..854		19/19 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..1251		292/366 (80%)
		DNA_pol3_delta2	<1070..>1130	CDD:331068	36/59 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1264..1293		22/28 (79%)
		HCFC1-binding motif (HBM)	1299..1303		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1417		83/112 (74%)
		Interaction with CFP1	1415..1450		32/34 (94%)
		N-SET	1425..1562	CDD:314603	133/136 (98%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269\|PubMed:17998332	1450..1537		84/86 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1472..1499		25/26 (96%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	1492..1497		4/4 (100%)
		SET	1568..1691	CDD:214614	122/122 (100%)
		PostSET	1691..1707	CDD:214703	15/15 (100%)
Setd1a	XP_038957149.1	RRM_Set1A	92..186	CDD:409964	93/93 (100%)
		N-SET	1441..1578	CDD:403078	133/136 (98%)
		SET_SETD1	1572..1719	CDD:380946	146/146 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83694886
Domainoid	1	1.000	2202	1.000	Domainoid score	I200
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	3100	1.000	Inparanoid score	I477
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43917
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001603
OrthoInspector	1	1.000	-	-		oto134660
orthoMCL	1	0.900	-	-		OOG6_101262
Panther	1	1.100	-	-	LDO	PTHR45814
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1161
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.400