DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD1A and Setd1a

DIOPT Version :10

Sequence 1:	NP_055527.1	Gene:	SETD1A / 9739	HGNCID:	29010	Length:	1707	Species:	Homo sapiens
Sequence 2:	NP_821172.2	Gene:	Setd1a / 233904	MGIID:	2446244	Length:	1716	Species:	Mus musculus

Alignment Length:	1725	Identity:	1547/1725 - (89%)
Similarity:	1590/1725 - (92%)	Gaps:	27/1725 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDLQDPRC 65
            |||||||||||||||||||||||||||||||||||||||||||||||||:||||.||||||||||
Mouse     1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVSDSKYTPVEDLQDPRC 65

Human    66 HVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPR 130
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 HVRSKARDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPR 130

Human   131 TRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPT 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 TRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPT 195

Human   196 GGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSF 260
            |||||||||||||||.||.|:||||||||||||||||..|||||||||||||:||||||||||||
Mouse   196 GGKALSEKFQGSGAAAETTEARRRSSSDTAAYPAGTTVGGTPGNGTPCSQDTNFSSSRQDTPSSF 260

Human   261 GQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTAST 325
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||.|||..|.:|
Mouse   261 GQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDSFSRRHFSTSSAPATTAT 325

Human   326 AIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATRE 390
            |.:||.||||:||:||||.|||||||||||:||||.||::|||||||||||||||||||||||||
Mouse   326 ATSATAAATAASSSSSSSSSSSSSSSSSSSASQFRGSDSSYPAYYESWNRYQRHTSYPPRRATRE 390

Human   391 EPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEP-------------GG 442
            :|.||.|||||||||||||||||.|||:|.||||||||||||||||||||             ||
Mouse   391 DPSGASFAENTAERFPPSYTSYLAPEPNRSTDQDYRPPASEAPPPEPPEPGGGGGGSGGGGGGGG 455

Human   443 GGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLA 507
            |||||.|||||||.||.||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 GGGGGAPSPEREEARTPPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLA 520

Human   508 SDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQN 572
            |||||||||||...||||.|:|||||:|||||||||||||||||||||||||||.||||||||||
Mouse   521 SDTEEEEENSSAGPGARDAGAEVPSGAGHGPCTPPPAPANFEDVAPTGSGEPGAARESPKANGQN 585

Human   573 QASPCSSGDDMEISDDDRGGSPPPAPTPPQQ-PPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPP 636
            ||||||||:|||||||||||||||||||||| |||||||||||||||||||||||||||||||||
Mouse   586 QASPCSSGEDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPP 650

Human   637 RPDGPPPPEY-PPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLI 700
            |||||||||| |||||||||||||||||||||||||||||||||||||||||||||||||||||.
Mouse   651 RPDGPPPPEYPPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLT 715

Human   701 AASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVS 765
            |||||||||||||||||||||||||||||||||.|||||||:|||||||||:|||||||||||||
Mouse   716 AASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYTQGQEGRGSYSREAYHLPLPMAAEPLPSSSVS 780

Human   766 GEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESK 830
            |||||||.|||||:||.|.||:|||||||||.|||||||||||||||||||||||||||||||||
Mouse   781 GEEARLPHREEAEIAESKVLPSAGTVGRVLATLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESK 845

Human   831 EEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKV 895
            ||||||||||||||||||||||.||||||:|||||||||||.|||||||||||||||||||||||
Mouse   846 EEKAKPFQNAAKQQAKEEDKEKMKLKEPGMLSLVDWAKSGGITGIEAFAFGSGLRGALRLPSFKV 910

Human   896 KRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFA 960
            |||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||.
Mouse   911 KRKEPSEISEASEEKRPRPSTPAEEDEDDPEREKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFT 975

Human   961 LDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDG 1025
            ||||||||||||||||||:||:||||||::|||||.||||.|.||||||:|||||:|||||||||
Mouse   976 LDSEGEEASQESSSEKDEDDDDEDEEDEEQEEAVDATKKEAEASDGEDEDSDSSSQCSLYADSDG 1040

Human  1026 ENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPA 1090
            ||.|||||||.||||||||||||||||||.|||       ||||:.|.:|||| ||||||.|.||
Mouse  1041 ENGSTSDSESGSSSSSSSSSSSSSSSSSSESSS-------EEEEQSAVIPSAS-PPREVPEPLPA 1097

Human  1091 PVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPI 1155
            |.|.|..:.:..|||.||.|:|..|.:||||.||.|||.|..|.|||||||..|||.||||||||
Mouse  1098 PDEKPETDGLVDSPVMPLSEKETLPTQPAGPAEEPPPSVPQPPAEPPAGPPDAAPRLDERPSSPI 1162

Human  1156 PLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKS 1220
            |||||||||||||||||.|..|.|||..|.|.|||..||.|||.||.||||||||||||||||||
Mouse  1163 PLLPPPKKRRKTVSFSAAEEAPVPEPSTAAPLQAKSSGPVSRKVPRVVERTIRNLPLDHASLVKS 1227

Human  1221 WPEEVSRGGRSRAGGRGRLTEEEEA-EPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSD 1284
            |||||:||||:|||||.|.|||||| |.|||||||||||||||||||||..||..:|||||||||
Mouse  1228 WPEEVARGGRNRAGGRVRSTEEEEATESGTEVDLAVLADLALTPARRGLATLPTGDDSEATETSD 1292

Human  1285 EAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEP 1349
            |||||.|||||||||||||||:||.|..||.||.||.||.|||||||||||||||||||||||||
Mouse  1293 EAERPSPLLSHILLEHNYALAIKPPPTTPAPRPLEPAPALAALFSSPADEVLEAPEVVVAEAEEP 1357

Human  1350 KPQQLQQQREEGEEEGEEEGEEEEEESSD--SSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPP 1412
            | ||||||..|.|.|.|||.||||.|||:  ||||||.|||:||||||||.||||||.|||||||
Mouse  1358 K-QQLQQQHPEQEGEEEEEDEEEESESSESSSSSSSDEEGAIRRRSLRSHTRRRRPPLPPPPPPP 1421

Human  1413 RAYEPRSEFEQMTILYDIWNSGLDSEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPK 1477
            .::|||||||||||||||||||||.|||||||||||||||||||||||||||||.||||||:|||
Mouse  1422 PSFEPRSEFEQMTILYDIWNSGLDLEDMSYLRLTYERLLQQTSGADWLNDTHWVQHTITNLSTPK 1486

Human  1478 RKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRR 1542
            ||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
Mouse  1487 RKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGGDTQGTNRVLSERRSEQRR 1551

Human  1543 LLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVA 1607
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1552 LLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVA 1616

Human  1608 DMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQ 1672
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1617 DMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQ 1681

Human  1673 PIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN 1707
            |||||||||||||||||||||||||||||||||||
Mouse  1682 PIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN 1716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SETD1A	NP_055527.1	Interaction with WDR82. /evidence=ECO:0000269\|PubMed:37030068	60..89		27/28 (96%)
		RRM_Set1A	92..186	CDD:409964	93/93 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..308		107/113 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..363		25/31 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..486		95/117 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..655		140/150 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..854		19/19 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..1251		288/360 (80%)
		PRK12323	<1070..>1130	CDD:481241	34/59 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1264..1293		22/28 (79%)
		HCFC1-binding motif (HBM)	1299..1303		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1307..1417		86/111 (77%)
		Interaction with CFP1	1415..1450		32/34 (94%)
		N-SET	1425..1562	CDD:463344	132/136 (97%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269\|PubMed:17998332	1450..1537		83/86 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1472..1499		25/26 (96%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000269\|PubMed:22266653, ECO:0000269\|PubMed:22665483	1492..1497		4/4 (100%)
		RxxxRR motif. /evidence=ECO:0000250\|UniProtKB:P38827	1537..1542		4/4 (100%)
		SET_SETD1	1556..1703	CDD:380946	146/146 (100%)
Setd1a	NP_821172.2	Interaction with WDR82. /evidence=ECO:0000250\|UniProtKB:O15047	60..89		27/28 (96%)
		RRM_Set1A	92..186	CDD:409964	93/93 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..367		150/172 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..499		96/118 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..670		143/153 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..869		19/19 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1206		238/302 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1230..1259		22/28 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1275..1297		16/21 (76%)
		HCFC1-binding motif (HBM). /evidence=ECO:0000250\|UniProtKB:O15047	1307..1311		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1355..1427		54/72 (75%)
		Interaction with CFP1. /evidence=ECO:0000250\|UniProtKB:O15047	1424..1459		32/34 (94%)
		N-SET	1434..1571	CDD:463344	132/136 (97%)
		Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250\|UniProtKB:O15047	1459..1546		83/86 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1480..1508		26/27 (96%)
		WDR5 interaction motif (WIN). /evidence=ECO:0000250\|UniProtKB:O15047	1501..1506		4/4 (100%)
		RxxxRR motif. /evidence=ECO:0000250\|UniProtKB:P38827	1546..1551		4/4 (100%)
		SET_SETD1	1565..1712	CDD:380946	146/146 (100%)

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DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETD1A and Setd1a

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.