DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KNTC1 and rod

DIOPT Version :9

Sequence 1:	NP_055523.1	Gene:	KNTC1 / 9735	HGNCID:	17255	Length:	2209	Species:	Homo sapiens
Sequence 2:	NP_476705.1	Gene:	rod / 43719	FlyBaseID:	FBgn0003268	Length:	2089	Species:	Drosophila melanogaster

Alignment Length:	2403	Identity:	492/2403 - (20%)
Similarity:	918/2403 - (38%)	Gaps:	565/2403 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWNDIELLT-NDDTGSGYLSVGSRKEHGTALYQVDLLVKISSEKASLNPKIQACSLSDGFIIVAD 64
            ||::.|..: .|:|.|...|  ||     .::|:.     |.|:.:..|.:.|.......:|..|
  Fly     1 MWSNFEASSLEDETISNIFS--SR-----GIFQIS-----SEEEVNKYPDVMASVQCGKMVIGID 53

Human    65 QSVILLDSICRSLQLHLVFDTEVDVVGLCQEGKFLLVGERSGNLH----------LIHVTSKQTL 119
            :|::||:....:....|.|...::.:.:...|..::.|...|.:|          .:.|..:...
  Fly    54 KSLLLLEDELVAKCSFLAFGAAIEAIAISSSGNLIVCGLSDGEVHGVFIKGLLLFSVAVNLEDVS 118

Human   120 LTNAFVQKANDENRRTYQNLVIEKDGSNEGTYYML------LLTYSGFFCITNLQLLKIQQA-IE 177
            ||....:..:..::|.|..       ...|:.|.|      .|...|...:...:.:..::| :|
  Fly   119 LTGGTFRSIHQLDQRFYFT-------CKNGSIYSLSDIDETCLETLGNMSLNENETIACEKALLE 176

Human   178 NVDFSTAKK-----------LQGQIKSSFISTENYHTLGCLSLVAGDLASEVPVIIGGTGNCAFS 231
            :|......|           |..::.:..||.||..         .||.::..::|.|
  Fly   177 DVTIQRLSKGRSSCSVDCAVLLKRLLTGNISAENNQ---------DDLEAQPGLVITG------- 225

Human   232 KWEPDSSKKGMTVKNL------IDAEIIKGAKK--FQLIDNLLFVLDTDNVLSLWDIYTLT---- 284
                |.|.  |..:|.      |:.....|:.|  |.|...::.:.|:.:::.:.. ||.|
  Fly   226 ----DQST--MNFRNAANDVTRINLPAQYGSLKQIFNLEHYIIALTDSGHLVEICP-YTRTVYMC 283

Human   285 PVWNWPSLHVEEFLLTTEADSPSSVTWQGITNLKLIALTAS-ANKKMKNLMVYSLPTMEILYSLE 348
            ......:|.:|:.|:...::.          |::|:.||.| |..:...::.|  ||:.:...:|
  Fly   284 QTTQQKNLLIEDLLVMECSED----------NIELLVLTKSTAEGRFIKIVEY--PTLNVKNEVE 336

Human   349 VSSVSSLVQTGISTDTIYLLEGVCKNDPKLSEDSV-SVLVLRCLTEALPENRLSRLLHKHRFAEA 412
            |...:.||:.......:|.|..     .::::.|: ||:.:..::|..|.:|..:|:.|.|..||
  Fly   337 VPDHAWLVRQPKCAVNLYYLAA-----KEVNQSSIPSVVEMMLVSETDPSDRFKKLICKGRLEEA 396

Human   413 ESFAIQFGLDVELVYKVKSNHILEKLALSSVDASEQTEWQQLVDDAKENLHKIQDDEFVVNYCLK 477
            |.|..||.|.::.:|:.|:..||.:|. :|...:..|::|.|:    :.|.:::...|:.::
  Fly   397 EEFGKQFELCLQPIYEAKAKRILVELC-NSNSQNVDTKFQDLL----QLLSQVESKAFIKSH--- 453

Human   478 AQWITYETTQEMLNYAKTRLLKK---EDKTALIYSDGLKEVLRAHAKLTTF--YGAFGPEKFSGS 537
                      .|:|.....:|::   |.|..|.:.|..:::|....:|...  .....|.: ..:
  Fly   454 ----------RMINLNSRHILERYLHEVKKRLTFEDDEEDMLEIDEQLHRLKTLAIIDPYE-CNT 507

Human   538 SWIEFLNNEDDLKDIFLQLKEGNLVCAQYLWLRHRANFESRFDVKMLESLLNSMSASVSLQKLCP 602
            .|.:|: .:::|..:...|...::..|..:|.||.::.....:...|.:||..:.::.....:..
  Fly   508 DWQKFI-YDNNLVRMVKSLFNTDMPTACLIWRRHSSSILPLLNEDELRTLLGFIPSNTKPFNVVQ 571

Human   603 WFKNDVIPFVRRTVPEGQIILAKWLEQAARNLELTDKANWPENGLQ----LAEIFFTAEKTDELG 663
            |.: ..||.|..|.|.....:..|..:..|||:.:  .:||:.||:    :.:||      :|:.
  Fly   572 WLR-QFIPMVSNTHPSIMPFITDWSIEMTRNLQYS--PHWPDIGLEFCTKILDIF------EEIQ 627

Human   664 LASSWHWISLKDYQNTEE--VCQLRTLVNNLRELITLHRKYNCKLALSDFEKENTTTIVFRMFDK 726
            ...|       |.:..:|  |.:||.|||.|::|..|...||....|.::.:::.......:...
  Fly   628 FTYS-------DVRRQQERNVGKLRDLVNALQDLSVLKTNYNMGFTLDNYMQDSIDATALSILQH 685

Human   727 VLAPELIPSILEKFIRVYMREHDLQEEELLLLYIEDLL-NRCSSKSTSLFETAWEAKAMAVIACL 790
            |...:| ..:::.|:....:|...|..:::..||..|: :|.||.|       |..:|||.|..|
  Fly   686 VQLDKL-QRLVKNFMYPIFQEKGRQPLDVIKQYISQLVASRLSSSS-------WLDRAMACIELL 742

Human   791 SDTDLIFDAVLKIMYAAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVN 855
            .:.|...:..|.::..|.|||...:..|::.... .||....:...|::..:|
  Fly   743 HNEDSRLECALSVLQNAPVPWPDTLAPLIRLRAS-THPLAVKINAEYEIQVIK------------ 794

Human   856 LLNKEIMRVVRYILKQDVPSSLEDALKVAQAFMLSDDEIYSLRIIDLIDREQGEDCLLLLKSLPP 920
                 ||:|     |...|:...|.          :.|::.:||:.|...:..:|...|.|:.|.
  Fly   795 -----IMKV-----KYGWPADSSDI----------NLELFMMRIVKLNLPDMLDDISALTKAAPE 839

Human   921 AEAEKTAERVIIWARLALQEEPDHSKEGKAWRMSVAKTSVDILKILCDIQKDNLQKKDECEEMLK 985
            .   .|:.......::|.:.:.:.:.|                          ..||...|:..|
  Fly   840 L---STSANFNCCYQMARRGQVEMAYE--------------------------FFKKLNGEKNSK 875

Human   986 LFKEVASLQENFEVFLSFEDYSNSSLVADLR-EQHIKAHEVAQAKHKPGSTPEPIAAEVRSPSME 1049
            ..|||..:..|.     .|:.|::|..:|:: ::|:...|:               .::..|.:|
  Fly   876 SAKEVVEIMANI-----LENSSSASFESDIKVQEHLNVLEL---------------FKLFLPHVE 920

Human  1050 SKLHRQALALQMSKQELEAELTLRALKDGNIKTALKKCSDLFKYHCNADTGKLLFLTCQKLCQML 1114
            |...|:.|.::.         ..|..|.|.:.:...:...|.:.||..|          :..:.:
  Fly   921 SVYERRYLVIKH---------RFRLRKFGILLSCSSELIPLHRRHCLLD----------EAIERI 966

Human  1115 ADNVPVTVPVGLNLPSMIHDLASQAATICSPDFLLDALELCKHTLMAVELSRQCQMDDCGIL--- 1176
            .:....|    ||:.:.|   ||:.:.:|:      ||.|.|    ...|.|.||...|..|
  Fly   967 IERAQAT----LNVSAFI---ASEISELCT------ALGLPK----VFGLHRICQRIGCLPLSCA 1014

Human  1177 -----------MKASFGTHKDPYEEWSYSDFFSEDGIVLESQMVLPVI-----------YELISS 1219
                       :.|:.|...:...|.......|..|...|:...|.:|           |||::|
  Fly  1015 LAYHVVSFVDCVPANAGEFVNLALELLVQQIESAKGKNQETASSLQLINENDPLSFYLAYELLTS 1079

Human  1220 LVPLAESKR-----------------YPLESTSLPY----------------------------- 1238
            .: |.||.|                 |||::....|
  Fly  1080 AL-LHESSRRHDLVELIKYIRVAVIHYPLDAIKSHYDGKEQAVNEHICRALDGISVALGETTINF 1143

Human  1239 -CSLN---EGDGLVLPVIN----SISAL----LQNLQESSQWE-LALRFVVGSF--GTCLQHSVS 1288
             |:||   :...|.:|...    |:|..    :|.:|:..|.: :..|..:..|  .|.|...:.
  Fly  1144 SCALNGSFDVKTLTVPTTTKKRYSVSMFDEVEVQPIQQQPQKKSVGGRMAIVKFLARTLLLMVIE 1208

Human  1289 NFMNATLSEKLFGE----------------------TTLVKSRHVVMELKEKAVIFIRENATTLL 1331
            ...|.:|..::..|                      .|.||.......:.:..:.|.::|..|
  Fly  1209 TEPNNSLLMQVRNELPENTKADVESACADFFLSLEHLTKVKEHDAWYVMSQYLLDFQKQNCRT-- 1271

Human  1332 HKVFNCRLVDLDLALGYCTLLPQKDVFENLWKLIDKAWQNYDKILAISLVGSELASLYQEIEMGL 1396
            .::.|...:.|.|...:...:..|||             |:.::..:.:|.||..:|.:::.:.:
  Fly  1272 KRIINEGFITLQLRRIFRNAMGSKDV-------------NFIELFTMLVVDSEALALLEKLSVEV 1323

Human  1397 K-------FRELST---------DAQWGIRLGKLGISFQPVFRQ--HFLTKK---------DLIK 1434
            |       |..||.         |:...||..:|.:.:...|.|  |.:..|         ||:|
  Fly  1324 KTDLQKINFLTLSAMYHEHIEDLDSVHMIRTKRLKLFYYLEFCQQDHRIKGKFNADMDNIEDLLK 1388

Human  1435 ALVENIDMDTSLILEYCSTFQLDCDAVLQLFIETLLHNTNAGQGQGDASMDSAKRRHPKLLAKAL 1499
            .. .|..:|..|:......|..|...:|   |..:|...:|.:.:.:...|:.......:|:.|.
  Fly  1389 EF-HNKQLDVQLLERMSKDFGFDYQKIL---ITQILSILSAQELRFEVKRDTFGDEELVMLSSAQ 1449

Human  1500 EM----VPLLTSTKDLVISLSGILHKLDP---YDYEMIEVVLKVIERADEKITNINI-NQALSIL 1556
            ||    .|.:....::.:..|.:.|.::.   |.||:...|:.::...|.....:.| ...|..|
  Fly  1450 EMRDMCQPYINEINNVELFTSKLKHFIEDINIYFYELYMCVINILMYFDSAPKEMEIWMNILHFL 1514

Human  1557 KHLKSYRRISPPVDLEYQYML----EHVITLPSAAQTRLPFHLIFFGTAQNFWKILSTELSEES- 1616
            :|....||.:.|..:|....|    |:.: :|..::.||||..|   ..|....||.:||:.::
  Fly  1515 RHKMITRRRNRPGQVETDTWLKSQRENGV-MPKISRYRLPFKPI---VEQPLKDILDSELNVDNC 1575

Human  1617 ---FP-----TLLLISKLMKFSLDTLYVSTAKHVFEKKLKPKLLKLTQAKSSTLINKEITKITQT 1673
               ||     |.|..||....:.|...:|..|:           .:::.||..  :.|...:..|
  Fly  1576 QSWFPLIQMYTALKGSKDSSQNCDYFCMSAVKN-----------SISEYKSKN--DSESWSLHPT 1627

Human  1674 IESCLLSIV-------NPEWAVAIAISLAQDIPEGSFKISALKFC-LYLAERWLQNIPSQDEKRE 1730
            ..:.|.||:       ||..|..|...::....:|:.::.|...| .::.|:  .::.:..:.||
  Fly  1628 NNAFLQSILRLVEKVNNPNKAFLILYFVSNYARDGADQVEASYECWKFVKEK--GHLITDPKSRE 1690

Human  1731 KAEALLKKLHIQYRRSGTEAVLIAHKLNTEEYLRVIGKPAHLIVSLYEHPSINQRIQNSSGTDYP 1795
            :...:.::..||    .|:.:|..:.|..|:.||.:..|..||.:||.|    :.|..||..
  Fly  1691 QVAKVKRRYPIQ----KTQHLLYVYGLTDEKLLRQVENPTELIQALYHH----ELILKSSKV--- 1744

Human  1796 DIHAAAKEIAEVNEINLEKVWDMLLEKWLC---PSTKPGEKPSELFELQED-------------- 1843
            ||:|...|||:::::.|..:...||:|||.   .|...|....|.|..:::
  Fly  1745 DINALVAEIAKLHDLCLATIQYRLLQKWLALTMESAGDGTILEETFMEEQNWPEQANGAESSNSQ 1809

Human  1844 ---EALRRVQYLLLSRPIDYSSRML--FVF---ATSTTTTLGMHQLTFAHRTRALQCLFYLADKE 1900
               |.:.|..|:|.|.|...:.:.|  .:|   :.:|:|.|.|:           :|...|.|.
  Fly  1810 DASENVNRAFYILSSWPKAEAVKFLVGLIFKGGSVNTSTQLQMY-----------ECYSKLNDG- 1862

Human  1901 TIESLFKKPIEEVKSY-LRCITFLASFETLNIPITYELF----CSSPKEGMIKGLWKNHSHESMA 1960
              .:.|...|.:.:.. ::|:..|   :.|......|.|    |:  |..::|.:|:.::...::
  Fly  1863 --SNSFTNTISQRQFISIKCVHEL---KALGYKSNLEKFSDDHCN--KIDILKMIWQRNAQNPLS 1920

Human  1961 VRLVTELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLKAISSIHSLWQVPYFSKAWQRVIQIP 2025
            :.::..:||.:.|:..|:|||:|::::.|:|:..|..:|..:|....|..:...::||..|:..|
  Fly  1921 LEVMANICLGFDIHLPQIWNGILKRMVMFHMVRELNALLDVLSCRPHLLHLDGLAQAWDYVLCHP 1985

Human  2026 LLSASCPLSPDQLSDCSESLIAVLECPVSGDLDLIGVARQYIQLELPAFALACLMLMPHSEKRHQ 2090
            |.:|....|..|.....::|:.:..|||...|:|:..|:..|.:..|..|.:.|.....||:| |
  Fly  1986 LQNAVELRSFKQEEVLHKTLLRLQGCPVVHALNLLQFAQLCIVVHRPHMAASLLSFCQSSEQR-Q 2049

Human  2091 QIKNFLGSCDPQVILKQLEEHMNTGQLAGFSHQIRSLILNNIINKKEFGILAKTKYFQMLKMH 2153
            :||..:                       .||.:.:| ...|::.::.|||.....|.:.:::
  Fly  2050 KIKKMI-----------------------HSHPVENL-RQQILDLEDAGILPVVLNFALKELN 2088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KNTC1	NP_055523.1	Rod_C	1583..2127	CDD:287465	137/590 (23%)
rod	NP_476705.1	Rod_C	1544..2082	CDD:287465	142/610 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160066
Domainoid	1	1.000	97	1.000	Domainoid score	I7308
eggNOG	1	0.900	-	-		E1_KOG4256
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3455
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52014
OrthoDB	1	1.010	-	-		D122381at2759
OrthoFinder	1	1.000	-	-		FOG0007375
OrthoInspector	1	1.000	-	-		oto91194
orthoMCL	1	0.900	-	-		OOG6_106565
Panther	1	1.100	-	-	LDO	PTHR15688
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3830
SonicParanoid	1	1.000	-	-		X6266
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.890