DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF646 and CG10274

DIOPT Version :10

Sequence 1:NP_055514.3 Gene:ZNF646 / 9726 HGNCID:29004 Length:1832 Species:Homo sapiens
Sequence 2:NP_001097525.1 Gene:CG10274 / 38716 FlyBaseID:FBgn0035690 Length:863 Species:Drosophila melanogaster


Alignment Length:918 Identity:178/918 - (19%)
Similarity:279/918 - (30%) Gaps:311/918 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   998 DAMEMVVDSVLEDIVNSVSGEGGDAKSQEGAGTP-LGDSLCIQGGESLLEAQPRPFRCNQCGKTY 1061
            :|.:..|.:|....:|.:...||.|.|.:....| |...||:  ..||...|...|....|.:.:
  Fly     6 EAAQYSVHAVCRICLNRLPENGGGAGSFDLFLIPGLAKKLCV--CTSLAVEQSDGFPKCLCAQCF 68

Human  1062 RHGGSLVNHRKIHQTGDFLCPVCSRCYPNLAAYRNHLRNHPRCKGSEPQV---------GPIPEA 1117
            .....:...:|:             |..::..:::.:..:..|..:..|:         |..||.
  Fly    69 SRLDDMHEFQKL-------------CVDSVQKFQDMVARNVFCPPASAQMKNFDLLNVAGNEPEL 120

Human  1118 AGSSE---LQVGPI----------PEGGSNKPQHMAEEGPGQAEVEKLQEEL------------- 1156
            .|..|   :...|:          .|......:|:.:|.. |.|.|..|:||             
  Fly   121 VGQDEEDRINFDPLLDHKMEMIENEEDVFKMLEHVDKEAE-QVEKEVKQDELDAADLMTIFAAES 184

Human  1157 -----------------------------------KVEPLEEVARVKEEVW------EETTVKGE 1180
                                               ::.|..:.|.:|||..      ||....||
  Fly   185 SEESEEDIDQDVDFEPNSSDGDDDVPLAQRLRDNSRMIPKAKAAVIKEEDQEFPTGSEEEDEDGE 249

Human  1181 EIEPRLETAEKGCQTEASSERPFSCEVCGRSYKHAGSLINHRQSH-QTGHFGC--QACSKGFSNL 1242
            :.:.|.:....|   |....|...|.:|.:.:|.|.....|.:.| ....|.|  :.|.|||:..
  Fly   250 KSKSRRKRIPPG---ERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTA 311

Human  1243 MSLKNHRRIHADPRRFRCSE--------CGKAFRLRKQLASH-QRVHMERRGGGGTRKATREDRP 1298
            ..|    |:|.|......||        |||.|...:.|..| :::|       |..||....|.
  Fly   312 GGL----RLHIDHAHTELSEVHSCNVDGCGKTFPRIRLLTFHMKKMH-------GITKAAAPPRD 365

Human  1299 FRCGQCGRTYRHAGSLLNHRRSHETGQYSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTA 1363
            :.|.:|.:.:|                     ||      ||||.|...|.         .:...
  Fly   366 YPCTECEKVFR---------------------CP------MALKKHMYKHD---------GKELP 394

Human  1364 VRCALCGRSFPGRGSLERHLREHEETEREPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPH 1428
            ..|.:||:.|....:|:.||..|                           .|::..:     .|:
  Fly   395 FPCNICGKRFVINSALKDHLMRH---------------------------AGIKNYV-----CPY 427

Human  1429 LEDGVPRPGERSQSPIRAASSEAPEPLSWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSV 1493
            .                            |.||           .....|....||.::|     
  Fly   428 C----------------------------GVGK-----------TTRQEWNTHILTHTQE----- 448

Human  1494 HRSPCHAGDCQLNGPTLSHMDSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNHNT---NKTD 1555
            .:..||.  |:                         |:|.::        .||.||..   .|..
  Fly   449 KKFKCHI--CE-------------------------HASHNK--------QSLANHIKIVHEKIK 478

Human  1556 RHYCLLCSKEFLNPVATKSHSHNHIDAQTFACPDCGKAFESHQELASHLQAHAR-------GHSQ 1613
            .:.|..|.|.|....|.|.|...|...:...|..|||.|...:.|..||:.|.:       .:.|
  Fly   479 NYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQ 543

Human  1614 VPAQM-----EEARDPKAGTGEDQVVLPGQGK---------AQEAPSETPRGPG--ESVERAR-G 1661
            ...:|     |:..:|.|...|...:.|...:         ..|:.:..|:.|.  :.|:.|: .
  Fly   544 RQVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADELLKVCAESVATIPKDPRRVQRVDLAQLA 608

Human  1662 GQAVTSMAA------------EDKERPFRCTQCGRSYRHAGSLLNHQKA--HTTGLYPCSLCPKL 1712
            |.||..:.:            ..||....|..||:.:.:.|::..|.|.  .....:.|..|||.
  Fly   609 GTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKR 673

Human  1713 LPNLLSLKNHSRTHTDPKRHCCSICGKAFRTAARLEGHGRVHAPREGPFTCPHCPRHFRRRISFV 1777
            .....:|::|...||..|...|..||..||....|:.|.|.|..|....:    |:.:..|....
  Fly   674 FAKAQTLRHHEWIHTGEKPFECKTCGTHFRQETALKRHQRTHENRPPVIS----PKFYAAREELE 734

Human  1778 QHQQQHQE 1785
            :.::..:|
  Fly   735 EQERSKRE 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF646NP_055514.3 C2H2 Zn finger 10..31 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..47
C2H2 Zn finger 50..70 CDD:275368
zf-C2H2 75..97 CDD:395048
C2H2 Zn finger 77..97 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 94..200
C2H2 Zn finger 241..261 CDD:275368
C2H2 Zn finger 268..288 CDD:275368
C2H2 Zn finger 296..316 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..346
C2H2 Zn finger 376..396 CDD:275368
C2H2 Zn finger 403..423 CDD:275368
C2H2 Zn finger 467..487 CDD:275368
C2H2 Zn finger 494..514 CDD:275368
C2H2 Zn finger 577..597 CDD:275368
C2H2 Zn finger 619..639 CDD:275368
C2H2 Zn finger 646..663 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..810
C2H2 Zn finger 823..843 CDD:275368
C2H2 Zn finger 850..870 CDD:275368
C2H2 Zn finger 883..901 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 901..931
C2H2 Zn finger 1054..1074 CDD:275368 2/19 (11%)
C2H2 Zn finger 1081..1101 CDD:275368 1/19 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1148 12/66 (18%)
C2H2 Zn finger 1205..1225 CDD:275368 5/19 (26%)
C2H2 Zn finger 1232..1252 CDD:275368 7/21 (33%)
C2H2 Zn finger 1260..1280 CDD:275368 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1294 5/20 (25%)
C2H2 Zn finger 1301..1321 CDD:275368 3/19 (16%)
C2H2 Zn finger 1328..1348 CDD:275368 7/19 (37%)
C2H2 Zn finger 1366..1386 CDD:275368 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1377..1481 10/103 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1509..1529 0/19 (0%)
C2H2 Zn finger 1533..1552 CDD:275368 4/21 (19%)
C2H2 Zn finger 1559..1579 CDD:275368 7/19 (37%)
C2H2 Zn finger 1587..1611 CDD:275368 9/30 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1606..1672 16/101 (16%)
C2H2 Zn finger 1679..1699 CDD:275368 6/21 (29%)
C2H2 Zn finger 1706..1726 CDD:275368 6/19 (32%)
C2H2 Zn finger 1734..1754 CDD:275368 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1781..1832 1/5 (20%)
CG10274NP_001097525.1 zf-AD 15..90 CDD:214871 17/89 (19%)
C2H2 Zn finger 334..353 CDD:275368 6/18 (33%)
C2H2 Zn finger 368..388 CDD:275368 10/46 (22%)
COG5048 394..729 CDD:227381 87/449 (19%)
C2H2 Zn finger 397..417 CDD:275368 7/19 (37%)
C2H2 Zn finger 425..445 CDD:275368 6/58 (10%)
C2H2 Zn finger 453..474 CDD:275368 9/55 (16%)
C2H2 Zn finger 482..502 CDD:275368 7/19 (37%)
C2H2 Zn finger 510..530 CDD:275368 8/19 (42%)
C2H2 Zn finger 638..659 CDD:275368 6/20 (30%)
C2H2 Zn finger 667..687 CDD:275368 6/19 (32%)
C2H2 Zn finger 695..715 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

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