DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF646 and CG12391

DIOPT Version :9

Sequence 1:NP_055514.3 Gene:ZNF646 / 9726 HGNCID:29004 Length:1832 Species:Homo sapiens
Sequence 2:NP_610639.1 Gene:CG12391 / 36170 FlyBaseID:FBgn0033581 Length:587 Species:Drosophila melanogaster


Alignment Length:719 Identity:139/719 - (19%)
Similarity:221/719 - (30%) Gaps:230/719 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   700 EDNEGLESP---QDPSGES----PHGAEGNLESDGDCLQAESEGDKCGLERDETHFQGDKESGGT 757
            |..:..|.|   ||.:|:|    ..|..|.:....|.|:     |..|...|:     |.|.|  
  Fly    21 ESAQNQEQPQPRQDLAGKSVGSADDGVSGTVGQIMDYLE-----DDAGATADQ-----DAEMG-- 73

Human   758 GEGLERKDASLLDNLDIPGEEGGGTHFCDSLTGVDEDQKPATGQPNSSSHSANAVTGWQAGAAHT 822
                   :|..||. ::|.|              ||.:.|.|.:.|.....::.....|..||  
  Fly    74 -------EAEYLDG-EMPQE--------------DESETPQTEKANEGCQESSNKKDLQESAA-- 114

Human   823 CSDCGHSFPHATGLLSHRPCHPPGIYQCSLCPKEFDSLPALRSHFQNHRPGEATSAQPFLCCLCG 887
                                                     :..|...:.||             
  Fly   115 -----------------------------------------KDDFSKEKSGE------------- 125

Human   888 MIFPGRAGYRLHRRQAHSSSGMTEGSEEEGEEEGVAEAAPARSPPLQLSEAELLNQLQREVEALD 952
               .|.......::..|......:.:|::|:|....:......|..:....|....::.:.:|||
  Fly   126 ---DGEKDTDKEKKATHLHEDNNDDAEKDGDEADAEDEDDVEKPEDEDGTEEGDEAIEEDEDALD 187

Human   953 SAGYGHICGCCGQTYDDLGSLERHHQSQSSGTTADKAPSPLGVAGDAMEMVV------DSVLED- 1010
                        :..|....:|.......:||.|:.........||..::.:      :.|.|| 
  Fly   188 ------------EDEDPNEEVEEIEPDFETGTDAEGELITGDEPGDLADVPIRERKKEEPVDEDQ 240

Human  1011 --IVNSVSGEGGDAKSQEGAGTPLGDSLCIQGGESLLEAQPRP-FRCNQCGKTYRHGGSL---VN 1069
              :..|........|.|..| ||....|.|....|:|.....| |.|.:|      .|||   :.
  Fly   241 CRVCTSKEELVCLFKKQIDA-TPADMLLVICPNVSILPKDFMPQFICTKC------MGSLTIAIQ 298

Human  1070 HRKIHQTGDFLCPVCSRCYPNLAAYRNHLRNHPRCKGSEPQVGPIPEAAGSSELQVGPIPEGGSN 1134
            .||..:|.|      ......|:..:|.:|   |.:|......|:.:   |||            
  Fly   299 LRKQLETTD------QELRKRLSRSKNKVR---RPRGYVVIDAPVTD---SSE------------ 339

Human  1135 KPQHMAEEGPGQAEVEKLQEELKVEPL------EEVARVKEEVWEETTVKGEEIEPRLETAEKGC 1193
                         :.::|.:|.||..:      :..:...::..:|....|....||.:..::|.
  Fly   340 -------------DEDELDDEFKVSDVAGTTSADSDSADSDDSEKEKKKPGPRGRPRKKPLKRGT 391

Human  1194 QTE---------------ASSERPFSCEVCGRSYKHAGSLINHRQSHQTGHFGCQACSKGFSNLM 1243
            .::               .:|..||.|..|..::....|.:.||::|:.....|..|.|.|....
  Fly   392 DSDGEPSSAQKKKYQPSSTASVGPFECPNCDLTFSRKQSYVLHRKTHERIEHACPICGKKFKVEW 456

Human  1244 SLKNHRRIHADPR-RFRCSECGKAFRLRKQLASHQRVHMERRGGGGTRKATREDRP---FRCGQC 1304
            :.|.|.:.|...| .|||..|.|.||||.:|..|.              |.|.|..   :.|.:|
  Fly   457 AYKTHMQRHEQERAHFRCELCPKIFRLRAELKHHM--------------AQRHDEHGFIYECKRC 507

Human  1305 GRTYRHAGSLLNHRRSHETGQYSCPTCPKTYSNRMALKDHQ------------RLHSEN-RRRRA 1356
            .||:.....|..|:         ...|.:...:.:.:|:.|            |.|..| .:||.
  Fly   508 QRTFLTQQRLQRHQ---------AVGCQRHKEDSVRIKEEQSRFKQESRSKDDRHHGNNSSKRRP 563

Human  1357 GRSR 1360
            |..|
  Fly   564 GEGR 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF646NP_055514.3 C2H2 Zn finger 10..31 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..47
C2H2 Zn finger 50..70 CDD:275368
zf-C2H2 75..97 CDD:333835
C2H2 Zn finger 77..97 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 94..200
C2H2 Zn finger 241..261 CDD:275368
C2H2 Zn finger 268..288 CDD:275368
C2H2 Zn finger 296..316 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..346
C2H2 Zn finger 376..396 CDD:275368
C2H2 Zn finger 403..423 CDD:275368
C2H2 Zn finger 467..487 CDD:275368
C2H2 Zn finger 494..514 CDD:275368
C2H2 Zn finger 577..597 CDD:275368
C2H2 Zn finger 619..639 CDD:275368
C2H2 Zn finger 646..663 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..810 27/116 (23%)
C2H2 Zn finger 823..843 CDD:275368 0/19 (0%)
C2H2 Zn finger 850..870 CDD:275368 1/19 (5%)
C2H2 Zn finger 883..901 CDD:275368 1/17 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 901..931 4/29 (14%)
C2H2 Zn finger 1054..1074 CDD:275368 7/22 (32%)
C2H2 Zn finger 1081..1101 CDD:275368 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1148 6/44 (14%)
C2H2 Zn finger 1205..1225 CDD:275368 5/19 (26%)
C2H2 Zn finger 1232..1252 CDD:275368 6/19 (32%)
C2H2 Zn finger 1260..1280 CDD:275368 9/19 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1294 2/19 (11%)
C2H2 Zn finger 1301..1321 CDD:275368 6/19 (32%)
C2H2 Zn finger 1328..1348 CDD:275368 4/31 (13%)
C2H2 Zn finger 1366..1386 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1377..1481
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1509..1529
C2H2 Zn finger 1533..1552 CDD:275368
C2H2 Zn finger 1559..1579 CDD:275368
C2H2 Zn finger 1587..1611 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1606..1672
C2H2 Zn finger 1679..1699 CDD:275368
C2H2 Zn finger 1706..1726 CDD:275368
zf-H2C2_2 1718..1743 CDD:372612
C2H2 Zn finger 1734..1754 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1781..1832
CG12391NP_610639.1 zf-AD 240..313 CDD:285071 21/85 (25%)
zf-C2H2 416..438 CDD:278523 6/21 (29%)
C2H2 Zn finger 418..438 CDD:275368 5/19 (26%)
zf-C2H2 443..465 CDD:278523 6/21 (29%)
C2H2 Zn finger 445..465 CDD:275368 6/19 (32%)
C2H2 Zn finger 474..491 CDD:275368 8/16 (50%)
C2H2 Zn finger 504..521 CDD:275368 5/16 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S8290
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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