Protein Alignment TMEM63A and tmem63a

DIOPT Version :10

• Sequence 1: NP_055513.2
• Gene: TMEM63A / 9725
• HGNCID: 29118
• Length: 807
• Species: Homo sapiens
• Sequence 2: NP_001082847.1
• Gene: tmem63a / 557924
• ZFINID: ZDB-GENE-041210-107
• Length: 802
• Species: Danio rerio
• Alignment Length: 780
• Identity: 425/780 - (54%)
• Similarity: 561/780 - (71%)
• Gaps: 42/780 - (5%)

Human    26 RPNDSYCYNSAKNSTVLQGVTFGGIPTVLLIDVSCFLFLILVFSIIRRRFWDYGRIALVSEAD-- 88
            |.:::.|::|.: ||||:||.|||||.|||:|.:.|:.|:.:|::|||:.|||||:|||:|.|
Zfish    18 RLDNTSCFSSTQ-STVLKGVNFGGIPVVLLLDFTVFILLLSIFTLIRRKLWDYGRLALVAETDVF 81

Human    89 ---SESRFQRLSSTSSSGQQDFENELGCCPWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLL 150
               .:.|:.||  |||...::.|.|.|||.|||.|..:.:..:.|.||.||:|||.||:|::.||
Zfish    82 GDGRKRRYSRL--TSSMSVEEPEYEKGCCSWLTFIVNMDETLVQERCGVDAVHYLPFQKHLVTLL 144

Human   151 VVVSFLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNDLLWLHTIFAVIYLFLTVGFMRHHT 215
            :::..||:.:|||||||||||..|||:||||||.|||.|:.||||||:|||:||.:||..:|.:|
Zfish   145 LIICVLSVSIILPVNLSGDLLGTDPYNFGRTTIGNLQHDDKLLWLHTVFAVLYLMITVFLLRRYT 209

Human   216 QSIKYKEENLVRRTLFITGLPRDARKETVESHFRDAYPTCEVVDVQLCYNVAKLIYLCKEKKKTE 280
            ..:|..:..:||.|||:..:||.:..:::::||.:|:|:|.|..|.|||:|||||.:.|.:|:.|
Zfish   210 SKMKGTKREIVRNTLFVRPIPRTSTDDSIKTHFMEAHPSCHVTSVNLCYDVAKLIDVNKNRKRAE 274

Human   281 KSLTYYTNLQVKTGQRTLINPKPCGQFCCC--EVLGCEWEDAISYYTRMKDRLLE---RITEEER 340
            |:|.:|..:..:.|:|.||||:||...|||  ...|||..|||.:|:..:..|.|   |:.:.|.
Zfish   275 KNLRHYNRILQQLGRRELINPRPCSHLCCCCQRCQGCEEVDAIEFYSSQEAALHEEEVRLKQGEL 339

Human   341 HVQDQPLGMAFVTFQEKSMATYILKDFNACKCQ---------------SLQCKGEPQPSSHSREL 390
            |    ||||||||.|.:.|||||||||||.:|.               ...|..|||||:.|.||
Zfish   340 H----PLGMAFVTLQNEYMATYILKDFNALECGGGARGVVGEEMSRGIKCGCGREPQPSTRSAEL 400

Human   391 YTSKWTVTFAADPEDICWKNLSIQGLRWWLQWLGINFTLFLGLFFLTTPSIILSTMDKFNVTKPI 455
            ...||.|.:|:.|.:|.|:|||::|.||.|:.:.:|..||:.||||||||||:|||||||||.||
Zfish   401 GVPKWKVNYASHPHNIYWENLSVRGWRWLLRCVLLNTALFVLLFFLTTPSIIISTMDKFNVTMPI 465

Human   456 HALNNPIISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIFLIFMVLILPSL 520
            :.||:||||||||||:||:||||||:|||||||.|:|||:|.||..||.|:|.||||||||||||
Zfish   466 YYLNSPIISQFFPTLMLWTFSALLPTIVYYSTLGEAHWTRSSENMSMMYKLYTFLIFMVLILPSL 530

Human   521 GLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRM 585
            |||||..|||||||| .||..:|.|||||.||||||||||||:|.:|:||||||||||:||..|:
Zfish   531 GLTSLAVFFRWLFDK-QSEGQLRFECVFLADQGAFFVNYVIAAALVGSGMELLRLPGLLLYIVRL 594

Human   586 IMAKTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIYILLKHMVDRHNL 650
            .:|.:||:|:.||||||:::::||||.|.|||||||:||||.||:|.||||:|:||||:||:|||
Zfish   595 ALASSAAERKYVKQNQAYEFQYGAMYGWTLCVFTVIMAYSIVCPLIVPFGLLYLLLKHLVDKHNL 659

Human   651 YFVYLPAKLEKGIHFAAVNQALAAPILCLFWLYFFSFLRLGMKAPATLFTFLVLLLTILVCLAHT 715
            ||.||||:|::.:|..||||||||||:||.||||||.||.|.....:|||.:||.:|:.:|:::|
Zfish   660 YFAYLPARLDRQVHLGAVNQALAAPIICLIWLYFFSVLRTGFMTGTSLFTLVVLCITVFICISYT 724

Human   716 CFGCFKHLSPLNY--KTEEPASDKGSEAEAHMPPPFTPYVPRILNGLASERTALSPQQQQQQTYG 778
            |||.||:|||.||  |.|:..:|..||..:.:     .|:|::||..||..:  |.:.....:||
Zfish   725 CFGHFKYLSPHNYNVKEEDEDADIVSENSSGL-----VYLPKVLNPDASFES--SDECSPSHSYG 782

Human   779  778
            Zfish   783  782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMEM63A	NP_055513.2	RSN1_TM	52..210	CDD:433613	87/162 (54%)
		Intracellular linker IL2, confers mechanosensitivity. /evidence=ECO:0000303|PubMed:37543036	219..414		92/214 (43%)
		PHM7_cyt	228..410	CDD:464272	86/201 (43%)
		RSN1_7TM	439..692	CDD:460661	184/252 (73%)
		Gating helix. /evidence=ECO:0000303|PubMed:37543036	555..586		23/30 (77%)
tmem63a	NP_001082847.1	RSN1_TM	45..208	CDD:433613	87/164 (53%)
		PHM7_cyt	223..420	CDD:464272	86/200 (43%)
		RSN1_7TM	431..700	CDD:460661	193/269 (72%)