Protein Alignment TMEM63A and Tmem63a

DIOPT Version :10

• Sequence 1: NP_055513.2
• Gene: TMEM63A / 9725
• HGNCID: 29118
• Length: 807
• Species: Homo sapiens
• Sequence 2: XP_006250426.1
• Gene: Tmem63a / 289318
• RGDID: 1306829
• Length: 810
• Species: Rattus norvegicus
• Alignment Length: 807
• Identity: 710/807 - (87%)
• Similarity: 757/807 - (93%)
• Gaps: 3/807 - (0%)

Human     1 MMDSPFLELWQSKAVSIREQLGLGDRPNDSYCYNSAKNSTVLQGVTFGGIPTVLLIDVSCFLFLI 65
            |..||||:.|.||||||||:|||||||||||||||||||||||||||||||||||:||.|||.||
  Rat     7 MTSSPFLDPWPSKAVSIRERLGLGDRPNDSYCYNSAKNSTVLQGVTFGGIPTVLLLDVGCFLVLI 71

Human    66 LVFSIIRRRFWDYGRIALVSEADSESRFQRLSSTSSSGQQDFENELGCCPWLTAIFRLHDDQILE 130
            ||||||||:|||||||||||||.||:||:|||| |||||||||:|||||.||:||||||||||||
  Rat    72 LVFSIIRRKFWDYGRIALVSEAGSEARFRRLSS-SSSGQQDFESELGCCSWLSAIFRLHDDQILE 135

Human   131 WCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNDLLWL 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   136 WCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNDLLWL 200

Human   196 HTIFAVIYLFLTVGFMRHHTQSIKYKEENLVRRTLFITGLPRDARKETVESHFRDAYPTCEVVDV 260
            ||:|:|||||||||||.|||:||:||||:|||:|||||||||:||||||||||||||||||||||
  Rat   201 HTVFSVIYLFLTVGFMWHHTRSIRYKEESLVRQTLFITGLPREARKETVESHFRDAYPTCEVVDV 265

Human   261 QLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRTLINPKPCGQFCCCEVLGCEWEDAISYYT 325
            ||||:|||||.||||:||||||||||||||||||:|||||||||||||||||.|||.||||||||
  Rat   266 QLCYSVAKLINLCKERKKTEKSLTYYTNLQVKTGRRTLINPKPCGQFCCCEVQGCEREDAISYYT 330

Human   326 RMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKDFNACKCQSLQCKGEPQPSSHSREL 390
            ||.|.|.||||.||..|||||||||||||:||||||:|||||||||||.|:|||||||||:||||
  Rat   331 RMNDSLTERITAEECRVQDQPLGMAFVTFREKSMATFILKDFNACKCQGLRCKGEPQPSSYSREL 395

Human   391 YTSKWTVTFAADPEDICWKNLSIQGLRWWLQWLGINFTLFLGLFFLTTPSIILSTMDKFNVTKPI 455
            ..|||:||||:.|||||||||||||:|||||.|||||:||:.||||||||||:||||||||||||
  Rat   396 CVSKWSVTFASYPEDICWKNLSIQGVRWWLQCLGINFSLFVVLFFLTTPSIIMSTMDKFNVTKPI 460

Human   456 HALNNPIISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIFLIFMVLILPSL 520
            ||||||:||||||||||||||||||:|||||||||||||:||||:||::||||||||||||||||
  Rat   461 HALNNPVISQFFPTLLLWSFSALLPTIVYYSTLLESHWTRSGENRIMVSKVYIFLIFMVLILPSL 525

Human   521 GLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRM 585
            ||||||||||||||||||:.|||||||||||||||||||||||||||:|||||||||||||||||
  Rat   526 GLTSLDFFFRWLFDKTSSDTSIRLECVFLPDQGAFFVNYVIASAFIGSGMELLRLPGLILYTFRM 590

Human   586 IMAKTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIYILLKHMVDRHNL 650
            ||||||||||||||||||:|||||||||||||||||:|||||||||.||||||||||||||||||
  Rat   591 IMAKTAADRRNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNL 655

Human   651 YFVYLPAKLEKGIHFAAVNQALAAPILCLFWLYFFSFLRLGMKAPATLFTFLVLLLTILVCLAHT 715
            ||.||||||||.||||||||||||||||||||:||||||||:.||||||||||.||.||.||.:|
  Rat   656 YFAYLPAKLEKRIHFAAVNQALAAPILCLFWLFFFSFLRLGLTAPATLFTFLVALLAILACLLYT 720

Human   716 CFGCFKHLSPLNYKTEEPASDKGSEAEAHMPPPFTPYVPRILNGLASERTALSPQQQQQQTYGAI 780
            ||||||||||.|||||||..||.:|||||.|||||||||||||||.||||||||  |||||||||
  Rat   721 CFGCFKHLSPWNYKTEEPVGDKRNEAEAHAPPPFTPYVPRILNGLTSERTALSP--QQQQTYGAI 783

Human   781 HNISGTIPGQCLAQSATGSVAAAPQEA 807
            .|||||:|||.:||..:.:||...||:
  Rat   784 RNISGTLPGQLVAQDPSDTVAGVYQES 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMEM63A	NP_055513.2	RSN1_TM	52..210	CDD:433613	144/157 (92%)
		Intracellular linker IL2, confers mechanosensitivity. /evidence=ECO:0000303|PubMed:37543036	219..414		168/194 (87%)
		PHM7_cyt	228..410	CDD:464272	157/181 (87%)
		RSN1_7TM	439..692	CDD:460661	236/252 (94%)
		Gating helix. /evidence=ECO:0000303|PubMed:37543036	555..586		29/30 (97%)
Tmem63a	XP_006250426.1	RSN1_TM	67..219	CDD:433613	140/152 (92%)
		PHM7_cyt	234..415	CDD:464272	157/180 (87%)
		RSN1_7TM	426..661	CDD:460661	216/234 (92%)