DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SEC14L5 and CG2663

DIOPT Version :9

Sequence 1:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens
Sequence 2:	NP_649535.2	Gene:	CG2663 / 40649	FlyBaseID:	FBgn0037323	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	53/295 - (17%)
Similarity:	109/295 - (36%)	Gaps:	60/295 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   249 LRHWLQ-ETHKGKIPKDEHILRFLRAHDFHLDKAREMLRQSLSWR------------KQHQVDLL 300
            :|.||: :.|..|...|..:..|||...|.|:|.::.|....:.|            .:.:::::
  Fly    34 IREWLETQPHLPKDMDDMRLTTFLRGCKFSLEKVKKKLDMYYTMRNAVPEFFSNRDINREELNIV 98

Human   301 LQTWQPPAL--------LEEFYAGGWHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSV 357
            |.....|.|        ...|..|    .|.|.:|.:||     |...:...:|:..|...  ||
  Fly    99 LDYVHCPTLPGITPNGRRITFIRG----IDCDFQPHHIL-----DAMKVALMIGDVRLAEE--SV 152

Human   358 NEEGQKRCEGSTRQLGRPISSWTCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIV 422
            ...|.                 ..:||....:..|..:.....:.:.:..|::.||..:..:.::
  Fly   153 GIAGD-----------------IFILDASVASAAHFAKFSPTVVKKFLIAVQEAYPVKVKEVHVI 200

Human   423 RAPRVFPVLWTLISPFINENTRRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGGESVCNVPEGGL 487
            ....:...::..:.||:.|..|.:...::...     .|...:.|:::|:..||::      ||:
  Fly   201 NISPLVDTIFNFVKPFVKEKIRSRITFHNDVE-----SLYKVVPRDLLPNEYGGKA------GGV 254

Human   488 VPKSLYMTEEEQEHTDQLWQWSETYHSASVLRGAP 522
            |..:.:..::..::|.......:...:.|:..|||
  Fly   255 VELNQWWKQKLVDNTQWFKDQEDKKANESLRPGAP 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214
		CRAL_TRIO_N	243..288	CDD:215024	13/39 (33%)
		SEC14	306..479	CDD:214706	30/180 (17%)
CG2663	NP_649535.2	CRAL_TRIO_N	28..74	CDD:215024	13/39 (33%)
CG2663	NP_649535.2	SEC14	95..250	CDD:238099	30/187 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910