DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SEC14L5 and CG33965

DIOPT Version :9

Sequence 1:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens
Sequence 2:	NP_001033983.1	Gene:	CG33965 / 3885668	FlyBaseID:	FBgn0053965	Length:	317	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	54/305 - (17%)
Similarity:	112/305 - (36%)	Gaps:	80/305 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   203 LEAHGPRS--TLGPALEAVSMDGDKLDADYIERCLGHLTPMQESCLIQLRHWLQ-ETHKGKIPKD 264
            :....|.|  .|.|.|:.|:::.           |..:....||.:..|:.||| :.|.....:|
  Fly     1 MSGSSPNSIRPLPPGLQKVAIEE-----------LNEVPSRVESDIAALKEWLQKQPHLCACLED 54

Human   265 EHILRFLRAHDFHLDKAREMLRQSLS--------WRKQHQVD--LLLQTWQPPALL-----EE-- 312
            :.:|.|||...|.|:||::.:.:..|        :..|..||  .:|:..:...:|     ||
  Fly    55 QFLLSFLRGSKFSLEKAKQKIDRFYSLQAVIPEVFNDQRLVDNAQVLEIIRLGVILRIPLDEEDT 119

Human   313 ------FYAGGW-----HYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSVNEEGQKRCE 366
                  ..||.:     .:||       |:|:|.|        .||      ::.:.::...
  Fly   120 GPAVTIIRAGSYDINKFKFQD-------IIRVGSM--------FGE------IMMLEDDNAS--- 160

Human   367 GSTRQLGRPISSWTCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLLIVRAPRVFPVL 431
                     :|.:..::|:.|:...:|:....:.|.:.....::..|.....:..:..|:.|...
  Fly   161 ---------VSGYLEIMDMSGVTGANLFALQPQLLSKFSAYADEAMPTRQKGIHFINVPKAFETG 216

Human   432 WTLISPFINENTRRKFLIYSGSNYQGPGGLVDYLDREVIPDFLGG 476
            :..:..:.....:.:..:.|     .|..:.:.:.:..:|:..||
  Fly   217 FKSLLGWFPGKIKERVSVSS-----DPEAIFERVPKHYLPEEYGG 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		3/12 (25%)
		CRAL_TRIO_N	243..288	CDD:215024	16/45 (36%)
		SEC14	306..479	CDD:214706	26/189 (14%)
CG33965	NP_001033983.1	CRAL_TRIO_N	32..77	CDD:215024	16/44 (36%)
CG33965	NP_001033983.1	SEC14	101..256	CDD:238099	25/192 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810