DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SEC14L5 and Ku80

DIOPT Version :9

Sequence 1:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens
Sequence 2:	NP_609767.2	Gene:	Ku80 / 34930	FlyBaseID:	FBgn0041627	Length:	699	Species:	Drosophila melanogaster

Alignment Length:	415	Identity:	90/415 - (21%)
Similarity:	145/415 - (34%)	Gaps:	100/415 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    72 IAGVEHVVFVQT-------NILNWKERTLLIEAHNETFANRVVVNEH---CSY--TVH-----PE 119
            |.|..::.::..       .|.|:..:....|.:|:.:|..:|...:   ||:  .:|     ..
  Fly   154 IVGTHNIAYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEALHTVFKVTN 218

Human   120 NEDWTCFEQSASLDIRSFFGFENALEK-IAMKQYTANVKRGKEVIEHYLNELISQGTSHIPRW-- 181
            ...|.   .:|.|:|.|....  :|:. ||||..|. ||..|...|.  :|::.:.|.|..:.
  Fly   219 RRPWV---WNAKLNIGSKISI--SLQGIIAMKNQTP-VKLVKVWAEK--DEIVIRETRHYIKGTE 275

Human   182 -TPAPVREEDARNQAG---PRDPSSLEAHGPRSTLGPALEAVSMDGDKLDADYIERCLGHLTPMQ 242
             ||.|..........|   |.|.:.||   |:....|.|....         :|:|   :..|.:
  Fly   276 ITPLPENLITGYMLGGTPVPYDEAVLE---PKEPHPPGLHFFG---------FIKR---NAVPDE 325

Human   243 ESC---LIQLRHWLQETHKGKIPKDEHILRFLRAHDFHLDKAREMLRQSLSWR-------KQHQV 297
            ..|   |..|.|  |:.::....|.:.::|.|.:.|          |..|.|:       :...|
  Fly   326 YFCGESLYLLVH--QKHNQSAAVKLDALVRALVSSD----------RAILCWKIYSTKFNRPQMV 378

Human   298 DLL--LQTWQPPA---LLEEFYAGGWHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHVLSV 357
            .||  |.....||   :||..|....|:.|...     ||        ..|....|..|..:..:
  Fly   379 VLLPRLADDTHPATLYMLEVSYTSQHHFWDFPA-----LR--------TTKTECSEEQLNAIDQL 430

Human   358 NEEGQKRCEGSTRQLGRPISSW--TCLLDLEGLNMRHLWRPGVKALLRMIEVVEDNYPETLGRLL 420
            .:.....|.....|..||   |  ..||..:.|  ..::...|..:|.. :|:.||..|.    .
  Fly   431 IDSTDLECTLRDTQQPRP---WAQNDLLPFDAL--PSIFEQNVMDILER-KVIYDNDKED----K 485

Human   421 IVRAPRVFPVLWTLISPFINENTRR 445
            :::......|.|.:..| :.|.::|
  Fly   486 MLKDKNFADVFWRVPDP-LEEKSKR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720	27/118 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214		9/41 (22%)
		CRAL_TRIO_N	243..288	CDD:215024	10/47 (21%)
		SEC14	306..479	CDD:214706	31/145 (21%)
Ku80	NP_609767.2	Ku_N	7..213	CDD:281693	11/58 (19%)
		KU80	221..524	CDD:238445	79/348 (23%)
		Ku_PK_bind	562..663	CDD:285938
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900