DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RUBCN and Plekhm1

DIOPT Version :9

Sequence 1:	XP_006713890.1	Gene:	RUBCN / 9711	HGNCID:	28991	Length:	1012	Species:	Homo sapiens
Sequence 2:	NP_611639.1	Gene:	Plekhm1 / 37520	FlyBaseID:	FBgn0034694	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	751	Identity:	168/751 - (22%)
Similarity:	290/751 - (38%)	Gaps:	149/751 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   296 SSTLTSPIEASWVSSQNDS---------PGDASEGPE----------------YLAIGNLDPRGR 335
            :|.|.:.:||.::....||         .||....||                ....|.......
  Fly    52 TSALCTTLEALFLHGLKDSFLSATFNVIAGDVERRPEPSFWAPCMVFMHKQVIEQVQGLSQITSE 116

Human   336 TASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSF---SEG-QTLT 396
            |..|::..  .:|.:.::||           |.|.:....| |.||...:|::.   ||| :|..
  Fly   117 TGQCRAWV--RQSLNESVFS-----------SYLNNMRKNG-SALSQYYKRNALMRDSEGLETAA 167

Human   397 VTSGAKKSHIRSHSDTSIASRGAPGGPRNITIIVEDPIAESCNDKAKLRGPLPYSGQSSEVSTPS 461
            ....:.:::::...            |.|.:::...|               .||.|.|::.||:
  Fly   168 KIMESLEAYVQFDL------------PVNSSLLNHWP---------------DYSLQLSDLWTPA 205

Human   462 SLYMEYEGGRYLCSGEGM------FRRPSEGQSLIS-YLSEQDFGSCADLEKENAHFSISESLIA 519
            ........|..:.|..|.      ..:|.:...|.| .:|...||       .|::|.:.|
  Fly   206 LKSCPISSGVDVASSLGSDIIAIPTPQPLQTNELFSESISNSPFG-------RNSNFGVPE---- 259

Human   520 AIELMKCNMMSQCLEEEEV-EEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSS 583
            ..:....:::.|..:|.:| .||.:..:..|..:...               |||..|      |
  Fly   260 LSQRENLDLLIQKFDEMDVINEEQTGGDKAETNETAE---------------QEAPSG------S 303

Human   584 SSQFSSRDSAQLSDSGSAD---EVDEFEIQDGSEGSNLTHISKNG-LSVSLAS----MFSDADIR 640
            .::...:.:.|:..|..||   |......|..:..|||...|.:| |..:..|    :......:
  Fly   304 KTRSRKKSNRQMDSSSFADLDLEAPSLLPQGSNSLSNLMQTSWSGDLEATPTSPTEELTGSRFFQ 368

Human   641 RNTASSSKSFVSSQSFSHCFL------HSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQ 699
            |:.:.||...:.|.:...|..      |.::.|:.| |..:.:|..: .:||.|....|:.|...
  Fly   369 RSVSVSSSVSLRSPTTDRCSYNALLRKHESNRESGA-GWSEIWEKFR-ASASNLNVAQPQRDTDP 431

Human   700 KLLPIPDSLPISPD--DGQHADI---YKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNY 759
                     |||.|  |.|..|.   ::|.......:|......|:.     ...|:..:..|.:
  Fly   432 ---------PISEDLSDLQSLDTNSEFELLTSEFDMVELQQMVAQLC-----QLAREPGLDAQGF 482

Human   760 RCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKI 824
            .|..|.......| ...:.|.:.|.|:|..|.:.....||:|::..|||.||.||..:...|.:.
  Fly   483 LCKSCQHPLGIGY-SNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEF 546

Human   825 WNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAK-ELLDSFDTVPGHLTEDLH 888
            .:.|..::|.:|..:|.....:.:::.||::|..::....||..:. |||.:......:|.|.:|
  Fly   547 RSHPFLDMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYEHIH 611

Human   889 LYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCE 953
            |||:.||...::|.|..:|.:..:.|..||.:|.||..||||||.||: ..:::||.:.....|.
  Fly   612 LYSIADLALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQS-PRVLYPFHISTTFRCL 675

Human   954 ECKACYHKACF-KSGSCPRCERLQARREALARQSLE 988
            .|.|.:|..|. :...||:|||::.|.:...:::::
  Fly   676 ACGAVFHAECLNEKQPCPKCERIRKREDQGLQEAVQ 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RUBCN	XP_006713890.1	RUN	122..182	CDD:214736
RUBCN	XP_006713890.1	zf-RING_9	777..977	CDD:290612	65/201 (32%)
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	27/156 (17%)
Plekhm1	NP_611639.1	zf-RING_9	500..700	CDD:290612	65/200 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144813
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1829
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750