Protein Alignment HERPUD1 and Herp

DIOPT Version :10

• Sequence 1: NP_055500.1
• Gene: HERPUD1 / 9709
• HGNCID: 13744
• Length: 391
• Species: Homo sapiens
• Sequence 2: NP_609151.2
• Gene: Herp / 34065
• FlyBaseID: FBgn0031950
• Length: 465
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 140/484 - (28%)
• Similarity: 206/484 - (42%)
• Gaps: 143/484 - (29%)

Human     4 ETEPE-PVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQ 67
            :..|| .|.||:||.||::.||.:..|..|:|..||.|||.:||.:|..:||:||||||||.|.|
  Fly    22 QKNPETSVRLLIKSSNQQYEDLNVDSDLCWTVQRLKKHLSLIYPGKPLIQDQKLIYSGKLLDDSQ 86

Human    68 CLRDLLPK----QEKRHVLHLVCN----VKSPSKMPEINAKVAESTEEPAGSNRGQYPE-DSSSD 123
            .:.:::..    .::.|:.||||.    ::..:|.|.:..|.|    .|||      || ..:::
  Fly    87 KISEVIRSYKDVYQQHHIFHLVCASKQVIRPAAKAPTVPQKDA----VPAG------PEVTGNAN 141

Human   124 GLRQREVLR-----------------NLSSPGWENISRPEAAQQAFQGLGPGF-SGYTPYGWLQL 170
            .||||....                 .|::| |.:.      .|..||..|.. :..:|:...|.
  Fly   142 ELRQRHAPHQQQAQQGNAGPHVTGDIGLANP-WTHF------WQQSQGAAPAANASASPHALFQQ 199

Human   171 ------SWFQQIYARQYYMQYLAATAA------SGAFVPPPSAQEIPVVSAPAPAPIHNQFPAEN 223
                  :|.||.||:  |||.|...:.      ||  :|||:...:|.|    |......|....
  Fly   200 QALIYNAWMQQAYAQ--YMQQLTLRSTLPGSNQSG--LPPPTQPLLPSV----PLIAGRNFGEVQ 256

Human   224 QPANQNAAP--QVVVNP---GANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYF 283
            |.|...|||  ||..:|   ||.||     :..|.::|:.|:: ||||..:|....::|:::|||
  Fly   257 QVAGAAAAPAAQVPADPQINGAPQN-----RNFPNIQEEPEMH-DWLDSFFSFTRLAIFVTVLYF 315

Human   284 YSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNL------------ 336
            .||..|.|:|:.....:||:|:|  ..|.|..:|..|       :|:  |||.
  Fly   316 NSSALRCLLVVLIAGAIYLYHIG--VLRRRRERNNNN-------INR--NNNAGDAAAFAAVQQI 369

Human   337 ---------QEGTDPE-TEDPNHLPP-------DRDVLD----GEQTSP---------------- 364
                     :|..||: ..:|..:|.       ::|.:|    |...:|
  Fly   370 QRMMDAAVQRENNDPQAANEPGAVPAAGPAAAGEQDAIDAPPAGAPVAPASAANPEPTDVSAEAV 434

Human   365 -------SFMSTAWLVFKTFFASLLPEGP 386
                   |.:|.......|||.|||||.|
  Fly   435 EPPNANNSVISVVRTFVITFFTSLLPEAP 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERPUD1	NP_055500.1	Ubl_HERP1	9..86	CDD:340638	35/80 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..126		7/26 (27%)
		Interaction with UBQLN1. /evidence=ECO:0000269|PubMed:18307982	115..200		28/115 (24%)
		Interaction with SYVN1. /evidence=ECO:0000269|PubMed:28827405	170..190		9/25 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..359		12/73 (16%)
Herp	NP_609151.2	Ubl_HERP	29..108	CDD:340488	34/78 (44%)