Protein Alignment ULK2 and ATG1

DIOPT Version :9

• Sequence 1: XP_016880913.1
• Gene: ULK2 / 9706
• HGNCID: 13480
• Length: 1057
• Species: Homo sapiens
• Sequence 2: NP_011335.1
• Gene: ATG1 / 852695
• SGDID: S000003148
• Length: 897
• Species: Saccharomyces cerevisiae
• Alignment Length: 1060
• Identity: 231/1060 - (21%)
• Similarity: 387/1060 - (36%)
• Gaps: 326/1060 - (30%)

Human     1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKEL 63
            |...|::...|.  :|.|:||.|:||.........||||.:::..|...::|  |..||.|||::
Yeast    18 MASAGNYTAEKE--IGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKI 80

Human    64 QHENIVALYDVQELPNSVFLVMEYCNGGDLA-------DYLQGNCVCVSVFSKDSAAACLILRAK 121
            :|.:||.|.|.:......:|:||||..|||.       :.::.:.:..:||.|....:    ...
Yeast    81 KHPHIVGLIDCERTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPS----ENH 141

Human   122 GTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLS-----YANRRKSSVSGI-------R 174
            ..|....:..:|.|:|:|::.|.||.::|||:||||:|||     |.:.:.....|.       .
Yeast   142 NGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPI 206

Human   175 IKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANS 239
            :|||||||||:|.:..:|.||||||:|||||::..|.|:|||||||:|||:::...|.|||:|::
Yeast   207 LKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRASN 271

Human   240 PQDLRMFYEKNRS----LMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS 300
              .|.:|.:..|:    ..||. ....|.|..|:..||..:...|:.||.||::..:.:......
Yeast   272 --HLELFKKIKRANDVITFPSY-CNIEPELKELICSLLTFDPAQRIGFEEFFANKVVNEDLSSYE 333

Human   301 CPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSK 365
            ....:|    .:...|.|...|..|.|            |.||..|..|.:.|...:..|...::
Yeast   334 LEDDLP----ELESKSKGIVESNMFVS------------EYLSKQPKSPNSNLAGHQSMADNPAE 382

Human   366 NSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRN 430
            .|....:..:|....:.:||:     ....::|||
Yeast   383 LSDALKNSNILTAPAVKTDHT-----QAVDKKASN------------------------------ 412

Human   431 YQRIEQNLTSTASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRP 495
             .:...:|.|..|       ..|..||....:..:..|         ||.....|
Yeast   413 -NKYHNSLVSDRS-------FEREYVVVEKKSVEVNSL---------ADEVAQAG---------- 450

Human   496 YSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNK 560
            ::|:|:             .||               ...|:...||:.   |.:|      .|:
Yeast   451 FNPNPI-------------KHP---------------TSTQNQNVLLNE---QFSP------NNQ 478

Human   561 QKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKT 625
            |..:.|..:|.....|.:....|....||..:    .:.|..|
Yeast   479 QYFQNQGENPRLLRATSSSSGGSDGSRRPSLV----DRRLSIS---------------------- 517

Human   626 TAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQ--SKAVFGRS 688
                .:..:.|.|..|.:                    |...|..|:.:|:.:||  |...:.::
Yeast   518 ----SLNPSNALSRALGI--------------------ASTRLFGGANQQQQQQQITSSPPYSQT 558

Human   689 VSTGKLSDQQGKTPICR--HQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSP 751
            :...:|..:..:..|.|  |....::|..:....::       :|.    :.|:...|:::....
Yeast   559 LLNSQLFHELTENIILRIDHLQHPETLKLDNTNIVS-------ILE----SLAAKAFVVYSYAEV 612

Human   752 PHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAPSLRYVPY 816
            ..|...|..|
Yeast   613 KFSQIVPLST------------------------------------------------------- 622

Human   817 GASPPSLEGLITFE-APELPEETLMEREHTD-------TLRHLNVMLMFTECVLDLTAMRGGNPE 873
                 :|:|:..|| ...:....:.|.:.:|       ||:...     .:|:...|..:|.
Yeast   623 -----TLKGMANFENRRSMDSNAIAEEQDSDDAEEEDETLKKYK-----EDCLSTKTFGKGR--- 674

Human   874 LCTSAVSLYQIQESVVVDQISQLSKDWGRV----------EQLVLYMKAAQLLAASLHL-AKAQI 927
                           .:...||||..:.::          |.:||||||..:|:.|:.: :....
Yeast   675 ---------------TLSATSQLSATFNKLPRSEMILLCNEAIVLYMKALSILSKSMQVTSNWWY 724

Human   928 KSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLN--RF-----FSDKQRFIDEINS---VTA 982
            :|.:.|.|..|..:|:.|.|::..|:.....|..|:|  ||     .::.|...::.:|   |..
Yeast   725 ESQEKSCSLRVNVLVQWLREKFNECLEKADFLRLKINDLRFKHASEVAENQTLEEKGSSEEPVYL 789

Human   983 EKLIYNCAVEMVQSAALDEM 1002
            |||:|:.|:|:.:.||..|:
Yeast   790 EKLLYDRALEISKMAAHMEL 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ULK2	XP_016880913.1	None
ATG1	NP_011335.1	STKc_ATG1_ULK_like	30..324	CDD:270911	109/300 (36%)
		DUF3543	586..893	CDD:403327	55/318 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I900
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24348
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.080