DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ULK2 and ulk2

DIOPT Version :9

Sequence 1:	XP_016880913.1	Gene:	ULK2 / 9706	HGNCID:	13480	Length:	1057	Species:	Homo sapiens
Sequence 2:	XP_002664661.3	Gene:	ulk2 / 100329702	ZFINID:	ZDB-GENE-090218-30	Length:	1034	Species:	Danio rerio

Alignment Length:	1072	Identity:	782/1072 - (72%)
Similarity:	879/1072 - (81%)	Gaps:	55/1072 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH 65
            ||.|||||||::||:|||||||||:|||::|||||||||||||||||||||||||||||||||||
Zfish     1 METVGDFEYSRKDLIGHGAFAVVFKGRHKKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH 65

Human    66 ENIVALYDVQELPNSVFLVMEYCNGGDLADYLQGNCVCVSVFSKDSAAACLILRAKGTLSEDTIR 130
            |||||||||||.|:|||||||||||||||||||                     |||||.|||:|
Zfish    66 ENIVALYDVQETPSSVFLVMEYCNGGDLADYLQ---------------------AKGTLREDTLR 109

Human   131 VFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATL 195
            |||.|||||||||:||||||||||||||||||..|:|||::|||||||||||||||.||||||||
Zfish   110 VFLQQIAAAMRILNSKGIIHRDLKPQNILLSYTGRKKSSINGIRIKIADFGFARYLQSNMMAATL 174

Human   196 CGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRE 260
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||:||:|:||||
Zfish   175 CGSPMYMAPEVIMSQNYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNKSLVPNIPRE 239

Human   261 TSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ-GPVKKSCPVPVPMYSGSVSGSSCGSSPSCR 324
            |||.|.:|||||||||||||:||:.||||||||. ..:|||||||||..||.||.|:||||||||
Zfish   240 TSPQLEDLLLGLLQRNQKDRIDFDTFFSHPFLEPISTIKKSCPVPVPSCSGLVSDSTCGSSPSCR 304

Human   325 FASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDS-ASTSSKNSSCDTDDFVLVPHNISSDHSCD 388
            :.|||||||||.:.|:.|||||||||||||:||:| .||||||||||||||||||| :|.:.|.|
Zfish   305 YVSPPSLPDMQTLPEDVLSSPPLGPPNYLQLSKESGGSTSSKNSSCDTDDFVLVPH-LSGEQSYD 368

Human   389 MPVGTAGRRASNEFLVCGGQCQPT------VSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTN 447
            :|:|..|||.|:|||:|||..||:      |||.|||.|||||||:||||||:|||:|  |..|.
Zfish   369 LPMGAVGRRPSSEFLLCGGSPQPSTGQTPMVSPRSETTPIPVPTQVRNYQRIKQNLSS--SPTTT 431

Human   448 VHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQC 512
            ::|||||..|||||||||||.:..|.||.||||.|||||||||||||||||||||||||||...|
Zfish   432 LYGSPRSGTVRRSNTSPMGFPKMVSASPSPADTVQTVGRRLSTGSSRPYSPSPLVGTIPEQLGHC 496

Human   513 CCGHPQGHDSRSRNSS-GSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHT 576
            ||||||.|:.|||:|| |||||.:|     |.|||||||||||||||:||||.||.||||.|:.:
Zfish   497 CCGHPQSHEPRSRSSSGGSPVPSSQ-----LLGARLQSAPTLTDIYQSKQKLHKQLSDPVHPTSS 556

Human   577 GAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLL 641
            ....::|||..||.:||||||||||||||:|||..|:|||||||||||.||||||||||||.||:
Zfish   557 AYPSNHSPQLGRPANLGTSPTKHLGSSPRTSDWLTKSPLPTIIGSPTKVTAPFKIPKTQASCNLM 621

Human   642 ALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQ-----GKT 701
            ||.....| .:...||.|  .|||......|.||.|.:.||..||||||.|:||:..     |..
Zfish   622 ALADSPIP-NKTLMDGRE--LCAHHCTAYPSSRQPAPEASKTSFGRSVSAGRLSEPPVRITLGGQ 683

Human   702 PICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLR 766
            |   :||||||||||||||.||||.|  .||...|   |.:.|:|||||||.|:..|||:|:..|
Zfish   684 P---YQGSTDSLNTERPMDTAPAGMC--ALAAGGG---SPRTVVFTVGSPPSSSTPPTCSHLASR 740

Human   767 TRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEAAP-SLRYVPYGASPPSLEGLITFE 830
            .|.||||.::|.||||:.||:|.:|||||...|||||||||.| ||||||||.|||||:|.||||
Zfish   741 PRATSVGSNSSAGSLCSTSGKVYMGSPPGMTIGSSPPGAEAGPSSLRYVPYGTSPPSLDGFITFE 805

Human   831 APELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQ 895
            ||||||||||||||||||.:|.:||.||:|||::.|:|.|.|:|..||.|||..|:|||||||||
Zfish   806 APELPEETLMEREHTDTLMYLRMMLSFTDCVLEIAALRAGGPDLGASAASLYPPQDSVVVDQISQ 870

Human   896 LSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLT 960
            ||::||:|||||||||||||||:|||||||||||.||:||||||||||:||||||.||::|::||
Zfish   871 LSREWGQVEQLVLYMKAAQLLASSLHLAKAQIKSAKLNPSTAVKQVVKSLNERYKSCISLCRRLT 935

Human   961 EKLNRFFSDKQRFIDEINSVTAEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSR 1025
            :|||.||||||||:||||||||||||||.||||||||||||||||||||.|||:||::|||||::
Zfish   936 DKLNHFFSDKQRFVDEINSVTAEKLIYNHAVEMVQSAALDEMFQQTEDIAYRYNKASMLLEGLTK 1000

Human  1026 ILQDPADIENVHKYKCSIERRLSALCHSTATV 1057
            |||||||||||.|||.|::||:||||:.|.|:
Zfish  1001 ILQDPADIENVIKYKASVDRRISALCYCTVTL 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ULK2	XP_016880913.1	None
ulk2	XP_002664661.3	PKc_like	2..272	CDD:304357	240/290 (83%)
		S_TKc	9..271	CDD:214567	233/282 (83%)
		DUF3543	818..1025	CDD:288883	160/206 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338024
Domainoid	1	1.000	739	1.000	Domainoid score	I994
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5891
Inparanoid	1	1.050	1509	1.000	Inparanoid score	I926
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44936
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		oto47594
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	1	1.100	-	-	LDO	PTHR24348
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.310