DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BLTP2 and hob

DIOPT Version :10

Sequence 1:NP_055495.2 Gene:BLTP2 / 9703 HGNCID:28960 Length:2235 Species:Homo sapiens
Sequence 2:NP_647789.2 Gene:hob / 38395 FlyBaseID:FBgn0035420 Length:2300 Species:Drosophila melanogaster


Alignment Length:2446 Identity:767/2446 - (31%)
Similarity:1194/2446 - (48%) Gaps:370/2446 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     8 LLVLLLVALSALFLGRWLVVRLATKW-CQRKLQAELKIG--SFRFFWIQNVSLKFQQHQQTVEID 69
            :|.|||..| |||:..:.|:.....| ..::.:.:::||  |..:..::||.:  .:...:|:|:
  Fly     2 MLQLLLFCL-ALFIFVYWVLPTGISWYLVKRFRVKVRIGRISLPYLSLKNVHI--SKSGFSVQIE 63

Human    70 NLWISSKLLSHDLPHYVALCFGEVRIRTD---------------LQKVSDLSAPFSQSAGVDQKE 119
            .:.:.|...:.::...:::...::||..|               |::...|:...|::.||....
  Fly    64 EVCLRSSFFTTEVTKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRTQTLAGKASEAKGVPDFR 128

Human   120 LSFSPSLLKIFCQLFSIHVDAINIMVLKVDTSESLWHIQISRSRFLLD----SDGKRLICEVSLC 180
            .:..|:.:..|.|..::||:.|:::::..|.... |.|..:.....||    .:.:.|:...:|.
  Fly   129 QTKVPASIITFAQFMAVHVNNISVVLMNNDFDPG-WFIHATAKELHLDGSIVQNARVLLVNAALS 192

Human   181 KINSKVL-----KSGQLED-----TCLVELSLALDLCLKVGISSR---HLTAITVDVWTLHAELH 232
            :..:|:|     :...||:     .||.|:|  .|:.|...:.::   .:..:::.:....:.:|
  Fly   193 EAQAKMLRHCSSRRQSLENLNKIRPCLGEVS--FDMTLDASLFAQGPLSMDTLSLVINNAKSVIH 255

Human   233 EGLFQSQLLCQGPSLASKPVPCSEVTENL--------------VEPTLPGLFLLQQLPDQVKVKM 283
            .||:  :.|.:.....|...|....|:.|              :.|.:|..|       ...:|.
  Fly   256 GGLY--EFLSEAKRRTSTGQPSRRSTQGLAPSKRSYDNDNYEKLAPIIPKNF-------NFSIKA 311

Human   284 ENTSVVLSMNSQKRHLTWTLKLLQFLYH-------RDEDQLPLRSFTANSDMAQMSTELLLEDGL 341
            ...|.| ..|||.   .::.||..|...       .||..| |.|..|......:..:...|..|
  Fly   312 ATFSAV-KENSQN---DFSAKLQSFQISGKFNSKVTDEKTL-LPSMLAKLGFHHLDIDTKYEKLL 371

Human   342 LLSQSRQRIVCLNSLKASVQVTTID-------LSASLVLNTCIIHYRHQEFSHWL--HLLALETQ 397
            .:.|                 .|||       .:..:.|.|..|.|.|.|...::  :.||.:..
  Fly   372 FVEQ-----------------FTIDSVLEKDIFNLYVKLKTFQIIYNHSEIYDFVNNNFLARQRS 419

Human   398 GSSSPVLKQRKKRTFPQ-------------------------ILAPIIFS--TSISNVNISIQLG 435
            ..:.|:....|:::.|.                         |:..|:..  ..:.||::.::|.
  Fly   420 SEAQPMQLIHKQKSLPDHLDLDTAVQSNLRANQRREGGVLEWIMQRIVVKGCAELFNVSLLMKLE 484

Human   436 DTPPFALGFNSISLDYQHLR---------PQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHV 491
            |        ..|::...|.|         ..::::...|.:                  ..|...
  Fly   485 D--------EHIAMSVSHTRFLLEQIEEKRSNLYENKFLNL------------------LLNQRQ 523

Human   492 WGEALVLDSF--TLQGSYNQPLGLSSTQS------------------DTLFLDCTIRGLQVEASD 536
            |...|::::.  .|..|.|....|..|.|                  :|..||.::...:.|.|.
  Fly   524 WSMELMVETLWSNLGNSINDTNNLKKTHSPGSPFFLGVSLVKLCSYANTTKLDISVHTFRTEYSM 588

Human   537 TCA-------QCLSRILSLMGPQ--SGKSAVSRHSSFGESV-----SLLWKVDLKVEDMNLFTLS 587
            ..|       :||.:...:. |:  ||:|....::....||     |...:|.:||:|:..:.::
  Fly   589 QLAEFVVKSMECLRQYRGIK-PKNMSGQSHARPNAGLTLSVQPSQSSTSLRVSVKVKDITAYFVN 652

Human   588 -----ALVGASEVRLDTLTILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSML 647
                 :|:..||:.|..     |...:|:.::...:|:::|:|  ....| ..|......:..|:
  Fly   653 HHNVYSLLSFSELNLSR-----SQSLTTLKLEEFQMAIMRSMT--ASSLC-LTDFSDVFATCKMI 709

Human   648 SITY---HSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVLATLQCRDLLRATVFPETVPSLALETS 709
            .:.:   ..::..|.:.....:...|:...||:|...|      ||:      .:....||:..|
  Fly   710 RLEHEQVEGTMGKLSIYIPGNMEATWNSNLHMHLLTLV------RDM------QDLKTELAIPAS 762

Human   710 GT--TSELEGRAPEPLPPKRLLNLTLEVSTAKLTAFVAEDKF-----ITLAAESVSLSRHGGSLQ 767
            ..  |:..||             ..:|:|..:.|.|  |.||     |.:..||:..|:....: 
  Fly   763 SVKKTTPKEG-------------FIVELSAERSTIF--EIKFSDRHSIQIFVESLFFSQKERCI- 811

Human   768 AYCPELAAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQY 832
            .|...:....|...||..||:::|.:|.||.:...|..||..|...|:||:.:.||....|||.:
  Fly   812 IYAENVFVKIDDQHIFTVKELDLQSVPRLEVLTQERQNFPGFQLPSNKVWVTTIGSFKAIFPYDH 876

Human   833 DFSRTLD-EAVGVQKWLKGLHQGTRAWASPSPV--PLPPDLLLKVEHFSWVFLDDVFEVKLHDNY 894
            ||...:: |.....||||.:|...:   .|..|  |||.||::|::.|.....||.|||||.|||
  Fly   877 DFYNAVNGECTSHFKWLKMVHNYKK---KPFTVDSPLPCDLVIKIKEFLLEISDDPFEVKLRDNY 938

Human   895 ELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPM 959
            .|:.||..||.||..|.|.|:..|..:. .|||:..||.|||:|.:||.|||||||:::..:.|:
  Fly   939 VLLVDEYLESLKRKALFDKKIGELCSER-LLLPSGTIEGLYANLVKKNSEIYIQRSKKIRESGPV 1002

Human   960 RRALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLV 1024
            |..||.|.:..:.::|:||.|.||..:|...::|:|..||:|.|||:....|||.:..:...:..
  Fly  1003 RTRLLAWIMTDVNIMAMADTSIHGYNNVTRIMREIDHESPWPEEGLEFSTLWCRGVNISCTEWKF 1067

Human  1025 RIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSE 1089
            .:||:|:.:|.::..||.|.|.|.||.|...::|...:.:|.|:|...::|:||.|||||||..|
  Fly  1068 MLRDFPQPMFCVKSMRLYGNLCGAEQMGSKRAKRDVFIDVGEPFGTDVIQRSMPSLKFYHDFDCE 1132

Human  1090 IFQYTVVWGPCWDPAWTLIGQC---VDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQ 1151
            :...:..:|.||:|   ::.||   .:.::.||.|||||||:|||.|||.||...:..:|..:..
  Fly  1133 LESCSYAFGACWEP---VMAQCNLSFEKISAPSKDPSPPLPFWDKLRLLLHGRLTLIAKQFTILL 1194

Human  1152 LATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWL 1216
            .|:.|||||||.|...|::........:.:|||:|::.|||||:||||..||.|:|.:|:.|:|:
  Fly  1195 HASLDPYNTTEEMELTWNNCGIVLTNAKIMFKGELNVTVRTASRYDDCRLLHFPNLKLTIKLKWV 1259

Human  1217 CHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSG---TISQPRILLY 1278
            |..||:|||:|...||:.|||....|:|||:|||||.|||:.|..:....:|   .:..|.::||
  Fly  1260 CLANPNDHHAVMPCAPDKLPEYSSNQVHDSFRAFRSLNLNIWISFETKPKAGEDLEVDIPSLVLY 1324

Human  1279 SSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQR 1343
            .|||||.::.....:.||||..||.:|||::|.||.|.:|||:.:......:.||.||.|.|.|:
  Fly  1325 GSTLRWFESLQLILSGVTRPTRRGPVFNNVRPRKKPLSRHYKKANLQMCLHKFQVLYWMSHALQK 1389

Human  1344 GIQ-----IECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVHLMASPTE---- 1399
            |.|     :..|..|..|     |.|....::.|..:|||...|..:|:...:.|.:..||    
  Fly  1390 GFQLNGRRVSFSSEHSLT-----LNPIDDGLIHRPRADWSTIYMNCELNDAEIWLKSILTEKMDS 1449

Human  1400 --ENADHCLDPL-VTKTHLLSLSSLTYQRH-----SNRTAEEELSARDGDPTFHTHQLHLVDLRI 1456
              ||.....|.. :.:.:.||::.::|.|.     :..:.||::.|:...|   ||:|.:.||:.
  Fly  1450 SSENLASAADAFKIVRFYFLSVAKVSYGREALIPTTATSTEEDVKAQSTTP---THKLVVYDLKG 1511

Human  1457 SWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGL-KIDPQMPAKKPKRGVPTSASAPPR----- 1515
            :||.:|||:||.|:|.:.|:..||.||||||:|.. |..|.....|.||...|...:...     
  Fly  1512 AWTKSNRDVAFALFDSFMKSQKLKNNLSTEAVKSYRKEGPNSAVLKHKRSDSTITLSSTNNEVLP 1576

Human  1516 VNTPSFSGQPDKGSSGGAYMLQKLIEETD-RFVVFTEEESGMSD--QLCGIAACQTDDIYNRNCL 1577
            ::.|:.|.:..........|||:||.|.| :|.|::::.|..|.  ||.|:.||...||.:.|..
  Fly  1577 ISNPNASMKKAPAQIHATAMLQQLIAEADHKFNVYSDDHSTQSRELQLQGLQACSAQDIIHENWS 1641

Human  1578 IELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSP 1642
            |.|||.|::|:|.||.|.||:|||||::||.:|.|.|...:|..||:|..||:.|||:||..:..
  Fly  1642 ISLVNSQVLLKGCETSGYVIISAAKAEILQREHRPVWRERSLISKTTWKGLLECMQYYATVSAGD 1706

Human  1643 TEQ--DGRQLWLEVKNIEEHRQ---RSLDSVQELMESGQAVGGMVTTTTD--WNQPAEAQQAQQV 1700
            ...  :...:||.|.||::..:   .:|..:..|:.||::|||:|:.|..  .:..:...|..|:
  Fly  1707 NNSLLEKEIMWLTVDNIQDKDETVINNLPDISHLVGSGRSVGGVVSETVGAFLSDNSGGAQPVQL 1771

Human  1701 QRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEISTN 1765
            |||:|:|.|..:|:||...|||...|::.||   .::|.:...:||:..||.|||:||:|::.||
  Fly  1772 QRIVSKCKCEFFYVSYGDAIDPNSITEVPPP---PSEELQSPWEKQDDPVDAFTLMHHDLDVCTN 1833

Human  1766 PAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQ 1830
            ..||||||||||||||:|||:||:.:||..|:||||::.|. |:|:..|...|..:|..:.:||.
  Fly  1834 SLQYAMILDIVNNLLLYVEPQRKQAAEKLTRMRFQLQLHST-EDQKRPIQQKQTVIRSLLMKIRS 1897

Human  1831 LEKQMYSIMKSLQDDSKNENLLDLNQK---LQLQLNQEKANLQLESEELNILIRCFKDFQLQRAN 1892
            |||..:.|.|...:|..:   |:|.|:   :|..:.:.|..|...||:|::::.|:|:.||.:.:
  Fly  1898 LEKDTHMISKERIEDGDS---LELRQEYDHVQQMIRESKEELNTFSEDLDMMLLCYKETQLSQLS 1959

Human  1893 KMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGW 1957
            |:...:..|.|::||..|..|.:|:|||||.|||:|||:|.|..|||:|.:||||:.|||||||.
  Fly  1960 KISNVRSDESVTMVRTNEICFKRAQWRLTETDGQIGIADLVLSAFLYTKKSKSDDSVEHLLELGN 2024

Human  1958 FTMNNLLPNAVYKVVL--------RPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLT 2014
            ..|.||||..:|:.||        .|..:    .:..||:|.:.:.||||||||||||:||.|:|
  Fly  2025 IRMENLLPREIYRDVLLATEIQKDMPVDT----HKRVLRIFCREKAPVGGISVKEHFEINVAPIT 2085

Human  2015 IQLTHQFFHRMMGFFFPGRSVEDDEVGDEED----KSKLVTTGIPVVKPRQLIATDDAVPLGPGK 2075
            |.:|.:|:..|:.|.||.|...:.||.||.|    .|...||.:                  ..|
  Fly  2086 IAITKKFYSTMLKFCFPDRDASETEVSDELDDNASTSSASTTNL------------------QAK 2132

Human  2076 GVAQGLTRSSGVRRSFRKSPEHPV----DDIDKMKERAAMNNSFIYIKIPQVPLCVSYKG--EKN 2134
            ......|:.||..:...|..|..|    ||::||||||..|..|||||||:||:.|||||  |||
  Fly  2133 SSTSSSTKRSGKGKKGAKDSEFYVKIEKDDVEKMKERAEKNKLFIYIKIPEVPVRVSYKGNKEKN 2197

Human  2135 SVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKS 2199
            ..|..|.:||:|.|||||.||||||..:|:|..||:.:.:|.||:||.:.........|:..|  
  Fly  2198 LEDITDYSLVIPTLEYHNVTWTWLDLLLAMKSVSRRVIFSQAIKQKLHIHQRQPILSAGERAT-- 2260

Human  2200 DLNMQQQEEEEKARLLIGLSVGDKNPG-KKSIF-----GRR 2234
                 .||.|:||.:|.|..:.::|.. ||.:|     |:|
  Fly  2261 -----PQEAEDKAVMLFGNRLLNENRNQKKGVFKFASSGKR 2296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BLTP2NP_055495.2 Fmp27 26..674 CDD:431223 136/790 (17%)
Transmembrane domain. /evidence=ECO:0000250|UniProtKB:Q9VZS7 29..108 14/96 (15%)
Fmp27_GFWDK 1028..1160 CDD:402113 54/134 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1495..1529 7/38 (18%)
Apt1 1703..2176 CDD:463055 212/493 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2074..2099 6/24 (25%)
hobNP_647789.2 Fmp27 26..>414 CDD:431223 78/423 (18%)
Fmp27_GFWDK 1071..1203 CDD:402113 54/134 (40%)
Apt1 1774..2239 CDD:463055 212/493 (43%)

Return to query results.
Submit another query.