Protein Alignment PPP6R2 and fmt

DIOPT Version :10

• Sequence 1: XP_054182177.1
• Gene: PPP6R2 / 9701
• HGNCID: 19253
• Length: 1027
• Species: Homo sapiens
• Sequence 2: NP_001261470.1
• Gene: fmt / 38714
• FlyBaseID: FBgn0035688
• Length: 996
• Species: Drosophila melanogaster
• Alignment Length: 1036
• Identity: 265/1036 - (25%)
• Similarity: 409/1036 - (39%)
• Gaps: 288/1036 - (27%)

Human    69 MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDP 133
            |||......:::::.||:||:.||:|.:||:|||||||.|.:.|:::..|.:.:..||.|||.:|
  Fly     1 MFWDKGYAPSANIEALLEKENSTLEEFLDEEDILQECKTQKKNLVNYFTRPEVIRRLVELITTEP 65

Human   134 PLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGN 198
            ..|:....||:|.|.:||:||..:|.:.::|..|...|.|||.:|:.||||||||:||||||...
  Fly    66 SEDVPMSKRFRYANMSCEILTLGLPSLDEKLLNDAETLQLLYSYLEKEPPLNPLLSSFFSKTFSM 130

Human   199 LIARKTE-----------QVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQDVLH 252
            |..:|.|           |::.::|.:..|:..:.||..|..:.||:::::..:|...|::::..
  Fly   131 LFTKKPEQDWFLYQHMCLQLLEYIKSQKTFLDFICKHFDTPVIPDLIMQMMKDIEGGRLKRNLFE 195

Human   253 WLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGR--DQGSQLQEALEP-----DPLLTAL 310
            ||.|:|:::||:.::...|:.|:.:|.:...||::..||  .|..|..::.||     :|:|..:
  Fly   196 WLTEDKIVERLIAILRNPQETDKHANVADFFCDLINQGRLMRQTEQENDSFEPAFDGSNPILKTI 260

Human   311 ESQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVD--SFSQGLERS--YAVSSS 371
            |..|.:|.||..:.:.:..||.::||..|:|||::......|...|  ...|..||.  ..|..:
  Fly   261 EFADTIEALLNVILEPNAQESAILSGISVVLTLIKPITFTDEPNSDRQRLLQKREREIHQEVQET 325

Human   372 VLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPSINQELCRL 436
            |:..:.|||::|..:|.|||.|..:.||..||..|.|..||...|:..|||.|...:|.|.:|..
  Fly   326 VITVMAPRLQEFVHILKNPPAKPTLETTAAVLTPPFGKTRLQVCRVFTALLETKHETIQQAICAT 390

Human   437 NTMDLLLDLFFKYTWNNFLHFQ------------------------------------------- 458
            ....||||.|.:|.||||||.:
  Fly   391 EYFSLLLDFFKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEVTDYFTADCLINAFLKVGTEE 455

Human   459 -------------------------VELCIAAILSHAAR----------------------EERT 476
                                     :|:.:||....||:                      |...
  Fly   456 SEVEMKNALNDAKRAEGGKDEEGGDIEIEVAAAQEVAAQTPDERQTAAEENQEHEEHMSQVEAAA 520

Human   477 EASGSESRVEPPHENGN---------------------RSLETPQPAASLPDNTMVTHLFQKCCL 520
            ||:.||. .||..::..                     ..|:..:...|.|.:.|.:||...|.|
  Fly   521 EATASED-AEPKAQDNEVKNSEVDGESPTDQQESEATLNDLDKTKTVPSPPPSEMQSHLIVNCHL 584

Human   521 VQRILEAWEANDHTQAA-GGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRWE 584
            :.::::.|:.|...|:| .|.|.|.||||.:|..             ||:..|
  Fly   585 ISKLVDLWQHNAQAQSAEKGRRLGYMGHLIKILR-------------HITNCI------------ 624

Human   585 SFVEETLTETNRRNTVDLVSTHHLHSSSEDEDIEGAFPNELSLQQAFSDYQ-------IQQMTAN 642
                     :...:..||::     ||..|||       |:.|.|:..|.:       ::|.|..
  Fly   625 ---------SESEHIGDLIT-----SSLSDED-------EVKLWQSLIDAETGEFSLAVKQQTKL 668

Human   643 FVDQFGFNDEEFADQDDNINAPFDRIAEINF---------NIDADE-DSPSAALFEACCSDRIQP 697
            ..|   .|..|....:|..|   |...|||.         .:|..| ::....:|.|...:|.|
  Fly   669 LAD---CNPHEENQYNDGSN---DYTGEINAWNVGNLPYREVDCSELNNTLQDIFFAIDQNRFQ- 726

Human   698 FD---DDEDEDIWEDSD-------------TRCAARV--MARP---RFGAPHASESCSKNGPERG 741
            |.   ||||:|..|..|             |:.:..:  :|.|   :|....::.:....|....
  Fly   727 FGRNIDDEDDDDDEHGDHSGGGDGHGHGMFTKNSNTLNNLADPWDIQFAVLSSAPTQVNTGTANW 791

Human   742 G----QDGKASLEAHRDAPGA--GAP--PAPGKKEAPPVEGDSEGAMWTAVFDEPANSTPTAPGV 798
            |    .|..|..:||....|:  |.|  ..||::|    |.||..|..:|....|......|..:
  Fly   792 GTDFNSDNFADFDAHFSTFGSDLGMPISAPPGEEE----EEDSSPAPESATQVNPEEERQPAESI 852

Human   799 VKDVGSSVWAAGTSAPEEKGWAKFTDFQPFCCSESGPRCSSPVDTECSHAEGSRSQGPEKAFS-- 861
            ...||..|                         :....|     |:...||...:...|||.|
  Fly   853 GLAVGKGV-------------------------QDNLAC-----TDDQQAEYDNNANVEKAISDK 887

Human   862 --PASPCAWNVCVTRKAPLLASDSSSSGGSHSEDGDQKAASAMDA-----------VSRGP 909
              .:|.......|||...:|.     .|....||.:......:.|           :|.||
  Fly   888 LAESSVVETAAIVTRLQSVLL-----DGEDDYEDDEGMWTKPLGADRPSETEQITPISNGP 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP6R2	XP_054182177.1	SAPS	196..600	CDD:398279	124/537 (23%)
		PHA03247	<832..1022	CDD:223021	20/93 (22%)
fmt	NP_001261470.1	SAPS	129..459	CDD:398279	89/329 (27%)