DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PPP6R2 and fmt

DIOPT Version :9

Sequence 1:	XP_011529034.1	Gene:	PPP6R2 / 9701	HGNCID:	19253	Length:	990	Species:	Homo sapiens
Sequence 2:	NP_001261470.1	Gene:	fmt / 38714	FlyBaseID:	FBgn0035688	Length:	996	Species:	Drosophila melanogaster

Alignment Length:	954	Identity:	246/954 - (25%)
Similarity:	386/954 - (40%)	Gaps:	270/954 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    23 MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVSLITQDP 87
            |||......:::::.||:||:.||:|.:||:|||||||.|.:.|:::..|.:.:..||.|||.:|
  Fly     1 MFWDKGYAPSANIEALLEKENSTLEEFLDEEDILQECKTQKKNLVNYFTRPEVIRRLVELITTEP 65

Human    88 PLDMEEKVRFKYPNTACELLTCDVPQISDRLGGDESLLSLLYDFLDHEPPLNPLLASFFSKTIGN 152
            ..|:....||:|.|.:||:||..:|.:.::|..|...|.|||.:|:.||||||||:||||||...
  Fly    66 SEDVPMSKRFRYANMSCEILTLGLPSLDEKLLNDAETLQLLYSYLEKEPPLNPLLSSFFSKTFSM 130

Human   153 LIARKTE-----------QVITFLKKKDKFISLVLKHIGTSALMDLLLRLVSCVEPAGLRQDVLH 206
            |..:|.|           |::.::|.:..|:..:.||..|..:.||:::::..:|...|::::..
  Fly   131 LFTKKPEQDWFLYQHMCLQLLEYIKSQKTFLDFICKHFDTPVIPDLIMQMMKDIEGGRLKRNLFE 195

Human   207 WLNEEKVIQRLVELIHPSQDEDRQSNASQTLCDIVRLGR--DQGSQLQEALEP-----DPLLTAL 264
            ||.|:|:::||:.::...|:.|:.:|.:...||::..||  .|..|..::.||     :|:|..:
  Fly   196 WLTEDKIVERLIAILRNPQETDKHANVADFFCDLINQGRLMRQTEQENDSFEPAFDGSNPILKTI 260

Human   265 ESRQDCVEQLLKNMFDGDRTESCLVSGTQVLLTLLETRRVGTEGLVD--SFSQGLERS--YAVSS 325
            |. .|.:|.||..:.:.:..||.::||..|:|||::......|...|  ...|..||.  ..|..
  Fly   261 EF-ADTIEALLNVILEPNAQESAILSGISVVLTLIKPITFTDEPNSDRQRLLQKREREIHQEVQE 324

Human   326 SVLHGIEPRLKDFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPSINQELCR 390
            :|:..:.|||::|..:|.|||.|..:.||..||..|.|..||...|:..|||.|...:|.|.:|.
  Fly   325 TVITVMAPRLQEFVHILKNPPAKPTLETTAAVLTPPFGKTRLQVCRVFTALLETKHETIQQAICA 389

Human   391 LNTMDLLLDLFFKYTWNNFLHFQ------------------------------------------ 413
            .....||||.|.:|.||||||.:
  Fly   390 TEYFSLLLDFFKQYCWNNFLHTEMEKALYVVFYNELSNNNTASTEVTDYFTADCLINAFLKVGTE 454

Human   414 --------------------------VELCIAAILSHAAR----------------------EER 430
                                      :|:.:||....||:                      |..
  Fly   455 ESEVEMKNALNDAKRAEGGKDEEGGDIEIEVAAAQEVAAQTPDERQTAAEENQEHEEHMSQVEAA 519

Human   431 TEASGSESRVEPPHENGN---------------------RSLETPQPAASLPDNTMVTHLFQKCC 474
            .||:.||. .||..::..                     ..|:..:...|.|.:.|.:||...|.
  Fly   520 AEATASED-AEPKAQDNEVKNSEVDGESPTDQQESEATLNDLDKTKTVPSPPPSEMQSHLIVNCH 583

Human   475 LVQRILEAWEANDHTQAA-GGMRRGNMGHLTRIANAVVQNLERGPVQTHISEVIRGLPADCRGRW 538
            |:.::::.|:.|...|:| .|.|.|.||||.:|..             ||:..|
  Fly   584 LISKLVDLWQHNAQAQSAEKGRRLGYMGHLIKILR-------------HITNCI----------- 624

Human   539 ESFVEETLTETNRRNTVDLVSTHHLHSSSEDEDIEGAFPNELSLQQAFSDYQ-------IQQMTA 596
                      :...:..||::     ||..|||       |:.|.|:..|.:       ::|.|.
  Fly   625 ----------SESEHIGDLIT-----SSLSDED-------EVKLWQSLIDAETGEFSLAVKQQTK 667

Human   597 NFVDQFGFNDEEFADQDDNINAPFDRIAEINF---------NIDADE-DSPSAALFEACCSDRIQ 651
            ...|   .|..|....:|..|   |...|||.         .:|..| ::....:|.|...:|.|
  Fly   668 LLAD---CNPHEENQYNDGSN---DYTGEINAWNVGNLPYREVDCSELNNTLQDIFFAIDQNRFQ 726

Human   652 ---PFDDDEDEDIWEDSDTRCAARVMARPRFGAPHASESCSKNGPERGGQDGKASLEAHRDAPGA 713
               ..||::|:|                            .::|...||.||.          |.
  Fly   727 FGRNIDDEDDDD----------------------------DEHGDHSGGGDGH----------GH 753

Human   714 GAPPAPGKKEAPPVEGDSEAGAMWTAVFDEPANSTPTAPGVVRDVGSSVWAAGTSAPEEKGWAKF 778
            |.    ..|.:..:...::...:..||.    :|.||..    :.|::.|  ||....:    .|
  Fly   754 GM----FTKNSNTLNNLADPWDIQFAVL----SSAPTQV----NTGTANW--GTDFNSD----NF 800

Human   779 TDFQPFCC---SESGPRCSSPVDTECSHAEGSRSQGPEKASQAS 819
            .||.....   |:.|...|:|...|   .|...|..||.|:|.:
  Fly   801 ADFDAHFSTFGSDLGMPISAPPGEE---EEEDSSPAPESATQVN 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPP6R2	XP_011529034.1	SAPS	150..555	CDD:282368	124/538 (23%)
fmt	NP_001261470.1	SAPS	129..465	CDD:282368	89/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149450
Domainoid	1	1.000	134	1.000	Domainoid score	I5014
eggNOG	1	0.900	-	-		E1_KOG2073
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2838
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000781
OrthoInspector	1	1.000	-	-		otm40469
orthoMCL	1	0.900	-	-		OOG6_100938
Panther	1	1.100	-	-	LDO	PTHR12634
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R385
SonicParanoid	1	1.000	-	-		X542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780