DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRAM2 and TRAM

DIOPT Version :10

Sequence 1:NP_036420.1 Gene:TRAM2 / 9697 HGNCID:16855 Length:370 Species:Homo sapiens
Sequence 2:NP_726710.1 Gene:TRAM / 31042 FlyBaseID:FBgn0040340 Length:368 Species:Drosophila melanogaster


Alignment Length:387 Identity:144/387 - (37%)
Similarity:209/387 - (54%) Gaps:50/387 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     5 RRT--KSYPLFSQEFVIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVH 67
            |:|  |:.|:.|.||||.|||||..|:.:..::|||.|.||..|..||...:|:|......|..:
  Fly     9 RKTSNKNPPILSHEFVIQNHADIISCVAMVFVVGLMNESTAAFASAFISLHHNVSGEDPSREQPY 73

Human    68 ---YHY--GPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVKHSKFNESGQLVVFHFTS 127
               |.|  |.||...|.||....||:||::||::||||||:|||||.|.::||||||||.|:..|
  Fly    74 GKPYTYIAGIKDYCAIFFYTLTCIIMHAIIQEFVLDKISKKLHLSKFKLARFNESGQLVAFYLLS 138

Human   128 VIWCFYVVVTEGYLTNPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQKV--RKEEIPR 190
            .:|..:|::.||||.....|||.:|...:.|..||:::.||||:||.||||||||:  ::|:.|:
  Fly   139 FVWGAHVLLKEGYLGQVAQLWEGFPDHPMSFLHKFYFVVQLAYYLHMLPELYFQKIKTKEEQQPK 203

Human   191 QLQYICLYLVH-IAG------AYLLNLSRLGLILLLLQYSTEFLFHTARLF--YFADENNEKLFS 246
                    :|| |:|      ||.|:..||.|:||.|.|.:|.|.|..:|.  :..:|...||..
  Fly   204 --------IVHSISGFTLIVLAYTLSFQRLALVLLTLHYFSELLSHVFQLIGVFDREERLAKLRV 260

Human   247 AWAAVFGVTRLFILTLAVLAIGFGLARMENQAFDPEKGNFNTLFCRLCVLLLVCAAQAWLMWRFI 311
            ...|||.:.|.....:.||.:.:|:..:.:                |..|..:.|.|.:|::.||
  Fly   261 VNNAVFFLIRFATSVIGVLTLYYGIGGVRS----------------LLALGGLIALQGYLVFSFI 309

Human   312 HSQLRHWREYWNEQSAKRRVPATPRLPARL----IKRESGYHENGVVKA-ENGTSPRTKKLK 368
            ..|||..||...|...:.::....:.||:.    :||:.   |:.:.:| :...||..:|||
  Fly   310 TEQLRAKREAKKEAKREAKLALQTKKPAKTPKDKVKRKK---ESDLPEADQTSPSPIKQKLK 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRAM2NP_036420.1 TRAM1 49..110 CDD:462460 30/65 (46%)
TLC 112..321 CDD:214789 78/219 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..370 7/22 (32%)
TRAMNP_726710.1 TRAM1 52..121 CDD:462460 31/68 (46%)
TLC 124..290 CDD:214789 67/173 (39%)

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