Protein Alignment CROCC and RPO21

DIOPT Version :10

• Sequence 1: NP_055490.4
• Gene: CROCC / 9696
• HGNCID: 21299
• Length: 2017
• Species: Homo sapiens
• Sequence 2: NP_010141.1
• Gene: RPO21 / 851415
• SGDID: S000002299
• Length: 1733
• Species: Saccharomyces cerevisiae
• Alignment Length: 1040
• Identity: 198/1040 - (19%)
• Similarity: 348/1040 - (33%)
• Gaps: 319/1040 - (30%)

Human   649 DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKA 713
            |.:.||..:|                         |:.|.::.|          |.:|.:...:|
Yeast   668 DTIADGPTMR-------------------------EITETIAEA----------KKKVLDVTKEA 697

Human   714 EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ 778
            :|..:..:..|| ||   .|.:|::.:.  |||  |:||
Yeast   698 QANLLTAKHGMT-LR---ESFEDNVVRF--LNE--ARDK-------------------------- 728

Human   779 EATVAREEQERLEELRLEQEVARQGLEGS-LRVAEQA----QEALEQQL-------PTLRH---- 827
               ..|..:..|::|...:::...|.:|| :.:|:.:    |:::|.:.       .||.|
Yeast   729 ---AGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMSACVGQQSVEGKRIAFGFVDRTLPHFSKD 790

Human   828 ----------ERSQLQEQLAQ--LSRQLSGREQELEQARREAQ------RQVEALERAAREKEAL 874
                      |.|.|:....|  ....:.|||..::.|.:.|:      |.|:|||......:..
Yeast   791 DYSPESKGFVENSYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDNT 855

Human   875 AKEHAGLAVQLV-------AAEREGRTL-----SEEA--TRLRLE----KEALEGSLFEVQRQL- 920
            .:...|..:|.:       ||..|.::|     |:.|  .|.|::    ...|:.||.|...::
Yeast   856 TRNSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEIL 920

Human   921 ------AQLEARREQLEAEGQALLLAKETLTGEL-----AGLRQQIIATQEKASLD----KELMA 970
                  ..|:...:||..:.:  .|.:..:.||.     ..:|:.|...|:...:|    .:|..
Yeast   921 GDLKLQVLLDEEYKQLVKDRK--FLREVFVDGEANWPLPVNIRRIIQNAQQTFHIDHTKPSDLTI 983

Human   971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAW----RELEAERAQLQSQLQREQ--EELLA 1029
            :.:|...::.|.:|...|..: |.:|..||:....:    |...|.|..||.....:|  :.:|:
Yeast   984 KDIVLGVKDLQENLLVLRGKN-EIIQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLS 1047

Human  1030 RLEAEKEELSEEIAALQQERDEGLLLAESEKQQA-------------LSLKESEKTALSEKLMGT 1081
            .:||:...     :.:......|:|.|:|..:.|             .|.|.:......::::..
Yeast  1048 NIEAQFLR-----SVVHPGEMVGVLAAQSIGEPATQMTLNTFHFAGVASKKVTSGVPRLKEILNV 1107

Human  1082 RHSLATISLEMERQKRDAQSRQEQ--------DRSTVNALT--SEL---RDLRA----QREEAAA 1129
            ..::.|.||.:..:...| :.|||        :.:|:.::|  ||:   .|.|:    :.||...
Yeast  1108 AKNMKTPSLTVYLEPGHA-ADQEQAKLIRSAIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEIIQ 1171

Human  1130 AHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL------------RLLEDARDGL--------R 1174
            .|   ...|.|:|.....|:...|...|..|..:            |:.:..::.|        .
Yeast  1172 LH---FSLLDEEAEQSFDQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTFKNDLFVIWSEDND 1233

Human  1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239
            .:|:...|.:|......|.:.:|...|::.  |.........|..|.:...|......::.....
Yeast  1234 EKLIIRCRVVRPKSLDAETEAEEDHMLKKI--ENTMLENITLRGVENIERVVMMKYDRKVPSPTG 1296

Human  1240 NEDKEQKLAL------LEEARTAVGKEAGELRTG----LQEV---ERSRLEARRELQEL------ 1285
            ...||.:..|      |.|..|..|.:...:.|.    :.||   |..|....:|:..:
Yeast  1297 EYVKEPEWVLETDGVNLSEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIASDGS 1361

Human  1286 ----RRQMKMLDSENTRLG----------------------RELAELQGRLALGERAEKESRR-- 1322
                |....::|...|:.|                      .|..|:  ....|..||.:..|
Yeast  1362 YVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEETVEI--LFEAGASAELDDCRGV 1424

Human  1323 -ETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARG 1386
             |.:.|.|....|..:.:||..|..:. :.:.||:          :..:|:.:........:..|
Yeast  1425 SENVILGQMAPIGTGAFDVMIDEESLV-KYMPEQK----------ITEIEDGQDGGVTPYSNESG 1478

Human  1387 -----LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGL 1446
                 |::|.|...:...:.|                         :.:|..||..:  ..|...
Yeast  1479 LVNADLDVKDELMFSPLVDSG-------------------------SNDAMAGGFTA--YGGADY 1516

Human  1447 GRAPSP--APRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSP-----GPATSPASPDLDP 1504
            |.|.||  |....|.||         |.|::||.....||...|.||     .|:.||.||...|
Yeast  1517 GEATSPFGAYGEAPTSP---------GFGVSSPGFSPTSPTYSPTSPAYSPTSPSYSPTSPSYSP 1572

Human  1505  1504
            Yeast  1573  1572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CROCC	NP_055490.4	Smc	<76..>672	CDD:440809	4/22 (18%)
		Rootletin	156..332	CDD:464459
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..518
		Smc	<555..>1057	CDD:440809	93/481 (19%)
		Smc	<816..>1368	CDD:440809	134/718 (19%)
		SMC_prok_B	1135..1927	CDD:274008	84/450 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1184..1226		7/41 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1443..1575		24/69 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1962..2017
RPO21	NP_010141.1	RNAP_II_RPB1_N	15..853	CDD:259848	49/256 (19%)
		RNA_pol_Rpb1_6	873..1056	CDD:461511	40/190 (21%)
		RNAP_II_Rpb1_C	1035..1446	CDD:132720	75/423 (18%)
		RNA_pol_Rpb1_R	1698..1709	CDD:461513