DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RAPGEF2 and BUD5

DIOPT Version :10

Sequence 1:NP_001338653.1 Gene:RAPGEF2 / 9693 HGNCID:16854 Length:1685 Species:Homo sapiens
Sequence 2:NP_009967.2 Gene:BUD5 / 850405 SGDID:S000000634 Length:642 Species:Saccharomyces cerevisiae


Alignment Length:242 Identity:62/242 - (25%)
Similarity:106/242 - (43%) Gaps:49/242 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   845 RYYLKNNMETETLCSDEDAQEL--------LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTE 901
            :|.:......:.||...|..:|        |.|.:...|.:|...:|..|::....|:.:||..|
Yeast   371 QYEIDKTNANDELCGATDLSDLLFQWKQGELLEVEAFALNVSPWSLAKTLTLLESSLYLDIETIE 435

Human   902 Y----------IDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIA 956
            :          ||.:|.|.               ||.:.:|....|::|:      .|.:::::|
Yeast   436 FTRHFKHNDTTIDSVFTLS---------------NQLSSYVLETTLQQTH------TISYWLQVA 479

Human   957 LHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP--NKYEKLFQDLQDLFDPSRNMAKYRNVL- 1018
            |.|...:|.||:.:||:.|....:.||     .||  .|.:.|||.|:.:..|:.|...||..: 
Yeast   480 LSCLYLRNLNSLASIITSLQNHSIERL-----SLPIDVKSDHLFQRLKVVVHPNNNYNVYRRTIK 539

Human  1019 NSQNLQPPIIPLFPVIKKDLTFLHEGND--SKVDGLVNFEKLRMIAK 1063
            :..:.|.|.:|...::.:|:||:.:|||  :|....||.:|...|.|
Yeast   540 HIFHSQLPCVPFTSLLIRDITFIRDGNDTFTKDGNNVNMQKFNQITK 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RAPGEF2NP_001338653.1 CAP_ED 37..143 CDD:237999
cNMP 297..412 CDD:197516
RasGEFN 428..541 CDD:214571
PDZ_RapGEF2_RapGEF6-like 545..627 CDD:467237
RA_PDZ-GEF1 769..851 CDD:340483 1/5 (20%)
RasGEF 874..1099 CDD:238087 55/205 (27%)
BUD5NP_009967.2 RasGEFN 230..339 CDD:214571
RasGEF 409..640 CDD:214539 55/204 (27%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.