Protein Alignment RAPGEF2 and rapgef2b

DIOPT Version :10

• Sequence 1: NP_001338653.1
• Gene: RAPGEF2 / 9693
• HGNCID: 16854
• Length: 1685
• Species: Homo sapiens
• Sequence 2: XP_017214662.1
• Gene: rapgef2b / 557693
• ZFINID: ZDB-GENE-030131-6959
• Length: 1629
• Species: Danio rerio
• Alignment Length: 1708
• Identity: 1313/1708 - (76%)
• Similarity: 1417/1708 - (82%)
• Gaps: 132/1708 - (7%)

Human     1 MASYVDNSFRQAVMKNPPERTPQDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLY 65
            ||||||||||||||.||.:||.|||||||||||||||||||||||||:|||||||||||||||||
Zfish     1 MASYVDNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLY 65

Human    66 YPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSFRRGCECIVLEPSEMIVVDYMDENEEYF 130
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
Zfish    66 YPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYF 130

Human   131 QRQASHRQSRRRFRKINQKGERQTIIDTVDPYPMGKPPLPRGYHTECTKSQLPADFTKLHLTDSL 195
            |||||||||||||||||||||||||||||||||.||||:.|||||||.|:||||||::|||.|.:
Zfish   131 QRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPVARGYHTECVKAQLPADFSRLHLADGI 195

Human   196 HPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASD 260
            |||||||||||||||||||||||||||||||||||.||||||||||||||||:||||||||||||
Zfish   196 HPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEPGDMDLSGLPETAVDSEEDDDEEDIERASD 260

Human   261 PLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVL 325
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   261 PLMSRDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVL 325

Human   326 NDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQ 390
            ||||||||||||||||||||:||.:.|||||||||||||||:||||||||:||||||||||||||
Zfish   326 NDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQ 390

Human   391 DYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTF 455
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
Zfish   391 DYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTY 455

Human   456 IEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFEN 520
            ||||||||||||.|||.|||:|||||:||||||||||||||||||||||||||||||.||||||.
Zfish   456 IEDFLLTYRTFLPSPMVVGKRLLEWFHDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEY 520

Human   521 NLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATE 585
            |||||||.|||||||||||||||.|::|||||||||||.|.|||||||||.||:|||:.||||.|
Zfish   521 NLEREKMCGHLRLLNIACAAKAKLRVVTLTKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAE 585

Human   586 AGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSE---------- 640
            |||||||||||||||||||:.||||.|||:|||||||||||||.||||||.|..:
Zfish   586 AGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVKTNLLVFKELLARPDQDQEQEQEEEP 650

Human   641 EKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISI 705
            :::|||||:||||||||||||||||||||||||:.|||.:||:|||:.|||||||||.|||..||
Zfish   651 DRKNGAPHIPKIGDIKKASRYSIPDLAVDVEQVMDLEKASKKAKANSAGGRNKLKKIFDKTLTSI 715

Human   706 LPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQV 770
            ||.|||||:|:|||||||||||:|:|.||.||||||.||||||||||||||||||:..||:.|||
Zfish   716 LPPKPYNDVGVGQSQDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFNNQPDMSDQV 780

Human   771 LRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSK 835
            |||||||||||||||.|||||||||.|||||||:||..:.||||||||||||||||||||:||||
Zfish   781 LRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEAYSLCEVSVTPEGVIKQRRLPEQLSK 845

Human   836 LADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPT 900
            ||||||||||||||:||||||||||||||||||||.||||||||||||||||||.||||..||||
Zfish   846 LADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCAIEPT 910

Human   901 EYIDDLFKLRSK-TSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 964
            |||||||||::: |...:||.|||.||:||||||:|::||.||||||||:|||||||||||||||
Zfish   911 EYIDDLFKLKTRLTGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALHCRECKN 975

Human   965 FNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIP 1029
            ||||||||||||||||:|||.||||||:||||||.|||||||||||||||||:||||||||||||
Zfish   976 FNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIP 1040

Human  1030 LFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGS 1094
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
Zfish  1041 LFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMAAVNMDPALMFRTRKKKWRSLGS 1105

Human  1095 LSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSL 1159
            |||||.||.||||.|||||||||||||||||||||||||||||||||||||.||.:||||||||:
Zfish  1106 LSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLTLETNEESLQTLSM 1170

Human  1160 QCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYP 1224
            ||||:.|||||:.||:|  :.:||||..||.:.|:.|           ..|.||.||||||:|||
Zfish  1171 QCEPSINTLPKSSGDRK--RPDTSPVVSRAATHQRQQ-----------LQKANQALQVPAVALYP 1222

Human  1225 SRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKG 1289
            ||||||||||||||.:|||:||||||||||.. :||:|||||::||.|||||||||||.|||:|.
Zfish  1223 SRKKVPVKDLPPFGTSSPQSLKKILSLSEEAG-DRHRKQAEDSVSNNSSQLSSPPTSPHSSPKKA 1286

Human  1290 GSGNQLRSFG-SGQLDLTSSSSSLGSYTLAPSG---TVDNFSDSGHSEISSRSSIVSNSSFDSVP 1350
            .:  .:||.| .|...|.|.|         |:|   ..|..|||||||||||||:||.||.|..
Zfish  1287 IA--SIRSHGMKGFSSLCSKS---------PTGYGRAGDYLSDSGHSEISSRSSLVSTSSLDMG- 1339

Human  1351 VSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEEL 1415
               .||||||:..:..|.:....|:|||...:|||||||||:.|.:.|||||.|||:||||:|||
Zfish  1340 ---QDERRQRYGGTAGEGHGSGHRLERRATADPDQYSLGSYSSMQDCRGLYAGATVLSSPSSEEL 1401

Human  1416 SQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSH 1480
            :||||||.|||||||||||||||||||||||||:|..||||.|..|          ||||.
Zfish  1402 TQDQGDRVSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWEALAEG----------AGLWG---- 1452

Human  1481 MDQIMFSDHSTKYNRQNQSRESLEQAQSRASWA------SSTGYWGEDSEGDTGTIKRRGGKDVS 1539
                                       ||.|||      ||...|||||||||||||||||:||:
Zfish  1453 ---------------------------SRGSWASACSSSSSVACWGEDSEGDTGTIKRRGGRDVT 1490

Human  1540 IEAESSSLTSVTTEET-----KPVPMPAHIAVASSTTKGLIARKEGRYREPPPTPPGYIGIPITD 1599
            .:.|:||:||..:||:     :|.|      :.:..||..|.||:||||:||||||||..:.|||
Zfish  1491 TDPETSSITSTGSEESRQHSRRPSP------ITAGNTKASITRKDGRYRDPPPTPPGYTALTITD 1549

Human  1600 FPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRL 1664
            ..||..|..||||||..||||||:|..|.|:      |||   |.:.:|            |||
Zfish  1550 VTEGTPHSGRKPPDYTTALQRSRLVTHSLDS------QQP---PAAGKP------------DPR- 1592

Human  1665 APYQSQGFSTEEDEDEQV 1682
                    ..||||..:|
Zfish  1593 --------GREEDEAVEV 1602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAPGEF2	NP_001338653.1	CAP_ED	37..143	CDD:237999	103/105 (98%)
		cNMP	297..412	CDD:197516	107/114 (94%)
		RasGEFN	428..541	CDD:214571	104/112 (93%)
		PDZ_RapGEF2_RapGEF6-like	545..627	CDD:467237	68/81 (84%)
		RA_PDZ-GEF1	769..851	CDD:340483	73/81 (90%)
		RasGEF	874..1099	CDD:238087	200/225 (89%)
rapgef2b	XP_017214662.1	CAP_ED	37..143	CDD:237999	103/105 (98%)
		cNMP	297..412	CDD:197516	107/114 (94%)
		RasGEFN	428..541	CDD:214571	104/112 (93%)
		PDZ_RapGEF2_RapGEF6-like	545..627	CDD:467237	68/81 (84%)
		RA_PDZ-GEF1	779..861	CDD:340483	73/81 (90%)
		RasGEF	884..1110	CDD:238087	200/225 (89%)