DRSC/TRiP Functional Genomics Resources

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Protein Alignment RAPGEF2 and RalGPS

DIOPT Version :10

Sequence 1:NP_001338653.1 Gene:RAPGEF2 / 9693 HGNCID:16854 Length:1685 Species:Homo sapiens
Sequence 2:NP_725613.1 Gene:RalGPS / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster


Alignment Length:568 Identity:120/568 - (21%)
Similarity:184/568 - (32%) Gaps:164/568 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   699 DKTRISILPQKPYNDIG--IGQS-------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSH 754
            |..|.|.|.:||..|..  .||:       |........|.:..||.:.     ...:|:...|.
  Fly    14 DNLRYSELSRKPTTDYNGYTGQAYAATQFKQSSPPPPPSQQQQQPTRVS-----KQRSPNTNGSA 73

Human   755 HRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQ----YSLCE 815
            |.:..........:|.:.......|:...:..|.|..|. .|..:..|  :::||.    |::..
  Fly    74 HTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKN-SIGCLNSF--SSSPDSPGCYYTIAA 135

Human   816 VSVTPEGVIKQRRLPDQLS-KLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLST 879
            .:..|.   |.:.||...| |..|.:.||.                              |::..
  Fly   136 SAAPPS---KSQSLPAHASIKQLDAVILSA------------------------------LRVPA 167

Human   880 VEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-----------NLKRFEEVINQETFWVA 933
            ..:|.|:::.:|.:|..|:|.|.          :|||           |:..|.:..|..:||..
  Fly   168 DVLANQITLLDFPVFAQIQPDEL----------SSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTV 222

Human   934 SEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLF 998
            .|||......:|.:||.||||:|....|..|.:|:|||||.:..|.:.||..||..|..|....|
  Fly   223 QEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAF 287

Human   999 QDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAK 1063
            ..|.|:|....|.|..|:.|.|  |:.|.||...:...||.::...:..|               
  Fly   288 DRLSDIFSDQDNWANLRSYLES--LRLPCIPYLGLFLTDLIYIDLAHPHK--------------- 335

Human  1064 EIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKL 1128
                                                           ||.:...||:...|..::
  Fly   336 -----------------------------------------------GGLEPEQRRNKMNNILRV 353

Human  1129 --------YEDAQMARKVKQYLSNL----ELE-MDEESLQTLSLQCEPATNTLPKNPGDKKPVKS 1180
                    |:..|.....::||:::    ||: :.||.....||..|||:.:.|.:.........
  Fly   354 ISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSSSSCSSKESF 418

Human  1181 ETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKK 1228
            ....|.|..|....:           ||..|............|..:|
  Fly   419 NVEVVTPALGCLNLS-----------PAKTIGSMRMASGTKFVPGHRK 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RAPGEF2NP_001338653.1 CAP_ED 37..143 CDD:237999
cNMP 297..412 CDD:197516
RasGEFN 428..541 CDD:214571
PDZ_RapGEF2_RapGEF6-like 545..627 CDD:467237
RA_PDZ-GEF1 769..851 CDD:340483 19/86 (22%)
RasGEF 874..1099 CDD:238087 58/235 (25%)
RalGPSNP_725613.1 RasGEF 169..335 CDD:459872 56/177 (32%)
PH_RalGPS1_2 578..692 CDD:270120
Blue background indicates that the domain is not in the aligned region.

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