DRSC/TRiP Functional Genomics Resources

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Protein Alignment RAPGEF2 and PDZ-GEF

DIOPT Version :10

Sequence 1:NP_001338653.1 Gene:RAPGEF2 / 9693 HGNCID:16854 Length:1685 Species:Homo sapiens
Sequence 2:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster


Alignment Length:1726 Identity:618/1726 - (35%)
Similarity:845/1726 - (48%) Gaps:458/1726 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   195 LHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERAS 259
            ||.:...  .|||..:.::.|||.:::..| |:..||.::|||||.|:.|||    ||||:..:.
  Fly    34 LHQKCNR--GSHSSDTSSAYSGSDTMASNY-ASSLEAEEIDLSGLVESVVDS----DEEDLAESM 91

Human   260 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIV 324
            |.|..||.|||||||||.:|:::|:|.||||...|.||.|:|::|||.||:|||||||::|||:|
  Fly    92 DSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVV 156

Human   325 LNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQ 389
            ::||||||||||::||:||:.:.:|..|.|.||:|||:.|||||.|.:||||||.||||||||.|
  Fly   157 MSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQ 221

Human   390 QDYCRILNQVEKNMQKVEEE-GEIVMVKEHRELDRTGT------------------RKGHIVIKG 435
            .||.||.:|.|:|.::.|:| |.:|||.|.|.:...||                  ::||:||:|
  Fly   222 TDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRG 286

Human   436 TSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN--------DPSLRDKVTR 492
            |.|||...||||:|:.|||::||||||:|.|:.:|.||..|||.||:        ...|||:|||
  Fly   287 TPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTR 351

Human   493 VVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAP 557
            ||||||||||.|||.|..|..|||.||..|||:|:...||||:|||||||:.|..|||:.||:.|
  Fly   352 VVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEP 416

Human   558 LPFILLGGSE----------KGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAME 612
            |.|.::||.|          ...||::..|:.||||.:.||||||||.|||||:.:::...:|:|
  Fly   417 LNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALE 481

Human   613 ILRNNTHLSITVKTNLFVFKELLTRLSEE----------------KRNGAPHLPKIGDIKK---- 657
            ||...|||||:||:||..|||::..|...                |...:|......||.|    
  Fly   482 ILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGR 546

Human   658 ------------AS------RYSIPDLAVD----------------------VEQVIGLEKVN-- 680
                        ||      |.|..|:.:|                      ::|:  |:.||  
  Fly   547 SDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQL--LQSVNNS 609

Human   681 --KKSKAN-------TVGG------RNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGL--- 727
              |||..|       |.||      :.:|:|.|.|..:       .|....|.|.:||...|   
  Fly   610 SAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNL-------LNKQNHGSSLNDSSDTLLND 667

Human   728 ------------RQTKHIPTALPVSG----TLSSSNPDL-----------------------LQS 753
                        ..|:.......|||    ..|.|||||                       |.:
  Fly   668 PKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNA 732

Human   754 H-HR-----ILDFSAT-----PDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTAT 807
            | ||     .|..::|     ||.||.||:|:||||..:|::|.|:|||.|||:..::||.:...
  Fly   733 HIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDP 797

Human   808 PDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQI 872
            ...:|||||||...|::|||||||||..||:||..:.|||||.|..||.|..||.|.||:|||.:
  Fly   798 SSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNV 862

Human   873 SLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEIL 937
            ..|.|:..|:|.||::::|..||.||.|||:|:||:|||:.....|.:|.|::|:|.|||.|||.
  Fly   863 HFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEIC 927

Human   938 RETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQ 1002
            .|.|.::||||:|.|||||.||:||:||||||||:|||....|:|||.||||||:||::||.|||
  Fly   928 AEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQ 992

Human  1003 DLFDPSRNMAKYRNVLNSQNL-QPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIR 1066
            ||.||||||:|||.:::::.| |.||||.:|::||||||:|.|||::||||:|||||||:|||:|
  Fly   993 DLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVR 1057

Human  1067 HVGRMASVNMD----PALMFRTRKKKWRSLGSLSQGSTNA---TVLDVAQTGGH---KKRVRRSS 1121
            .:..|.|...|    ..|..::......||..:|...:||   ||  :|...|.   |:|.:.::
  Fly  1058 LLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTV--IAANAGQATIKRRKKSTA 1120

Human  1122 FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPA-----------TNTLPK----- 1170
            ..|.||::|:|||.|:||.||::|::..||:.|...||:||||           .||..:     
  Fly  1121 APNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGG 1185

Human  1171 --------------------NPGDKKPVKSETS---------------PVAPRAGSQQKAQSLPQ 1200
                                |.||:..:.|.||               |.:|...:.....|...
  Fly  1186 SISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSD 1250

Human  1201 PQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAE 1265
            .|::  ..|  |.|                    |.||..||||:||:|||||...:..|    :
  Fly  1251 HQRR--QMH--NNG--------------------PKFGTASPQAVKKMLSLSESSKIRPH----Q 1287

Human  1266 DTISNASSQLSS--PPTSPQ------SSPRKGGSGNQLRSFGSGQLDLTS-SSSSLGSYTLAPSG 1321
            ..:....|.::.  ||....      |:|..||.             :|| ::|::.:....||.
  Fly  1288 PFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGV-------------VTSPATSAVANVQCTPSP 1339

Human  1322 TVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPD-- 1384
                 |...|..::|..:|:.:.       ::|:                  |....|...|.  
  Fly  1340 -----SPCSHRRLASGGNIIPSR-------AIHE------------------RSHSDTPAPPPPL 1374

Human  1385 ---QYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI 1446
               ..||.|                 ||.:|   .:|...|.|:.:     ||.:||.||     
  Fly  1375 PSVDLSLES-----------------SSVTT---FRDLPLRKSVTS-----GSISSCDSG----- 1409

Human  1447 QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRAS 1511
              ..||:.       |.|..|                           :|.|.:.|.:...|...
  Fly  1410 --YVHQQQ-------HYHLQY---------------------------QQQQQQNSSQHEPSPPV 1438

Human  1512 WASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMP----AHIAVASSTTK 1572
            :.::          |...:::.....|:... :|...|..|..:.|.|.|    |.|.:::..|.
  Fly  1439 YTAA----------DCRLLQQISNNAVTRNL-NSPCQSTNTPPSTPTPPPNQPTATIQLSAPPTA 1492

Human  1573 GLIARKEGRYRE----------PPPTPPGYIGIPITDFPEG--HSHPARKPPDYNVALQRSRMVA 1625
            ........::::          |||.||.| .:|    |.|  :||                   
  Fly  1493 AAYMHARSQHQQLQQQQQSLAMPPPPPPPY-NVP----PLGSIYSH------------------- 1533

Human  1626 RSSDTAGPSSVQQPHGHPT--------SSRPVNKPQ 1653
             ...|||...:...||..|        ..||..|.|
  Fly  1534 -HQGTAGSRHLNHMHGKTTGPQERWFPDCRPTTKQQ 1568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RAPGEF2NP_001338653.1 CAP_ED 37..143 CDD:237999
cNMP 297..412 CDD:197516 72/115 (63%)
RasGEFN 428..541 CDD:214571 71/120 (59%)
PDZ_RapGEF2_RapGEF6-like 545..627 CDD:467237 43/91 (47%)
RA_PDZ-GEF1 769..851 CDD:340483 44/81 (54%)
RasGEF 874..1099 CDD:238087 125/229 (55%)
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 70/108 (65%)
RasGEFN 279..400 CDD:214571 71/120 (59%)
PDZ_RapGEF2_RapGEF6-like 404..496 CDD:467237 43/91 (47%)
RA_PDZ-GEF1 759..841 CDD:340483 44/81 (54%)
RasGEF 871..1050 CDD:459872 109/178 (61%)
Blue background indicates that the domain is not in the aligned region.

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