Protein Alignment PRORP and mldr

DIOPT Version :10

• Sequence 1: NP_055487.2
• Gene: PRORP / 9692
• HGNCID: 19958
• Length: 583
• Species: Homo sapiens
• Sequence 2: NP_572309.2
• Gene: mldr / 31568
• FlyBaseID: FBgn0029858
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 545
• Identity: 148/545 - (27%)
• Similarity: 245/545 - (44%)
• Gaps: 83/545 - (15%)

Human    85 FLAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDL----KENTGKTSFESWII 145
            :||...|.|.|..|...|. |..:|:.:......|:..||.:::..|    |...|..  ...:|
  Fly    21 WLASQHKRRPQPGSLPADR-LDQLRSDLFERRHELSGAEWTEVRRSLVDGYKHINGHN--VDAVI 82

Human   146 SQMAGCHSSIDVAKSLLAWV---AAKNNGIVSYDLLVKYLYLCVFH------MQTSEVIDVFEIM 201
            ..:....:.:.:|||.:.::   .:|.|......||  .:|...:|      .:.||::.:...:
  Fly    83 LGVCSAPNQLSLAKSYVEFLRSRGSKPNAATLGRLL--RVYNAAYHERPLSEAEQSEILQICRSL 145

Human   202 KARYKTLEPRGYSLLIRGLI--HSDRWREALLLLEDIKKVITPSKKNYNDCIQGA--LLHQDVNT 262
            :|.::||:......:|.||:  ..|.|:..|.|||.:|...|||...|:...:.|  :...:...
  Fly   146 QAEHETLDASSCENVIHGLVATSGDDWQRGLPLLEMMKVTSTPSVAAYSALAEKAFSVATPEQEL 210

Human   263 AWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLD-----------ILSYLRNNQLYPG 316
            ||.|.:|:......|..|...|..            |:|.:           :|.:|..:::...
  Fly   211 AWRLLEEMATARKPPKCEVYLALL------------NRLANETAQLPAQLSLLLQFLERHEILVS 263

Human   317 ESFAHSIKTWFESVPGKQWKGQFTTVRKS-----GQCSGCGKTIESIQLSPEEYECLKGKIMRDV 376
            :..|..::.....||      |....|.:     |:|..|.:.::.:.:|.||:..|....:..|
  Fly   264 QRVAIRLQELSSQVP------QLLHTRTTHLGGLGKCQSCQQHLQPVAISDEEFRQLSECFLERV 322

Human   377 IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVA-----KMFPKVRESQLLLNVVSQLAKR 436
            :...|.::::||:|:.||:.|::...|:|.||||||||     |..|: :.::|:..||....::
  Fly   323 LIRRDVFQRSTPEEVARFKKFVEKTAPYDCVIDGLNVAYSTGTKKTPQ-QLAKLVATVVRHFREQ 386

Human   437 NLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLM 501
            :.|:|||||:||    ..||:..|..|...||.|...::|.||||||||||.||....|.:||||
  Fly   387 DKRVLVLGREHM----RNWSKQAMHYVHCNASLFLTSNLSHDDPFLLYATLRSGQETDFFSRDLM 447

Human   502 RDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDLVE 566
            |.|...| ..:.:.:|.:|||.||.::|.:....::..:..:.:........|:||:||
  Fly   448 RSHAFHL-GTELKPIFRRWQQEHQFSLVTQTQTGQIIVKEPVRHRLCAHQVADTWHVPY------ 505

Human   567 RC---------SCEVPTKWLCLHQK 582
             |         |.|||..|||:..|
  Fly   506 -CAQYTPHPTDSFEVPANWLCIQMK 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRORP	NP_055487.2	PPR repeat	174..204	CDD:276811	6/35 (17%)
		PPR repeat	210..239	CDD:276811	10/30 (33%)
		PPR repeat	244..271	CDD:276811	6/28 (21%)
		PRORP	342..578	CDD:465320	85/254 (33%)
mldr	NP_572309.2	PRORP	288..525	CDD:465320	84/249 (34%)