Protein Alignment PRORP and coa-6

DIOPT Version :10

• Sequence 1: NP_055487.2
• Gene: PRORP / 9692
• HGNCID: 19958
• Length: 583
• Species: Homo sapiens
• Sequence 2: NP_001366833.1
• Gene: coa-6 / 172906
• WormBaseID: WBGene00013893
• Length: 471
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 96/476 - (20%)
• Similarity: 181/476 - (38%)
• Gaps: 121/476 - (25%)

Human    93 RSQMNSQTEDHALAPVRNTIQLPTQPL--NSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSI 155
            ||..:..|....|.|..|: ..|...:  .|.::..|.....:..|.|..:| ::|::..|:|..
 Worm     6 RSIRSISTTSSCLFPTLNS-PFPRPEILEMSPKYQFLTTTTPQINGTTELQS-MLSEVLRCNSFF 68

Human   156 D--VAKSLLAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIR 218
            |  |..:::..|.::|:....:..|....|:.|.:...::     |..:...|.|:..    :.:
 Worm    69 DSTVFNNVVKMVESQNSFSRDFANLTAMRYIAVVYHSIND-----EEARLTLKRLKDN----IEK 124

Human   219 GLIHS-----DRWREAL---LLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQELLGH-- 273
            ..||.     |::|.:|   ..:.|..||:     :..|.::.....:..|..|...::||..
 Worm   125 CKIHKMQEEHDKFRMSLDQDAAIPDFSKVM-----HKQDLVRCYFRRELANKKWKTVKQLLSRYP 184

Human   274 DIVPMLETLKAFFDFGKDIKDDNYSN-KLLDILSYLRN---------------NQLYPGESFAHS 322
            ..:.:.|.:.||.|..|      ..| :.:||:....|               ::::...:.|.|
 Worm   185 KNIKLYEHISAFLDAAK------LENAEPIDIMQVFMNYAQVDNPRFMEQTEFDEIFKQVAEACS 243

Human   323 I-----------KTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQ---LSPEEYECLKGKIM 373
            .           ||:.....||..|.:            |.|.:||::   :..||||.::.|::
 Worm   244 AKVSVKSELDVKKTYISEKEGKILKEK------------CDKYVESMKEGFVKKEEYEKIRQKVL 296

Human   374 RDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVA-KMFPKVRESQLLLNVVSQLAKRN 437
            |.:.:          :.::..||.        ||:|.||.. .:.||..:     ::.|:.
 Worm   297 RWMEE----------RNIRNGENV--------VVVDALNFGYGVDPKEWD-----DISSKF---- 334

Human   438 LRLLVLGRKHML----RRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITR 498
                    :|:.    |.|:|..|.|:.| :...:..|.|.:|.||..::...|..|.....:|.
 Worm   335 --------EHVFFATRRISNQKLRKEVME-RYNGNALFCDKLSTDDLIIIRMALEFGPETSIVTN 390

Human   499 DLMRDHKA--CLPDAKTQRLF 517
            |...||::  |..|.|.:::|
 Worm   391 DKYTDHRSAICNGDQKLEKIF 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRORP	NP_055487.2	PPR repeat	174..204	CDD:276811	4/29 (14%)
		PPR repeat	210..239	CDD:276811	6/36 (17%)
		PPR repeat	244..271	CDD:276811	3/26 (12%)
		PRORP	342..578	CDD:465320	42/186 (23%)
coa-6	NP_001366833.1	Ribosomal_L7_L12	<227..294	CDD:481186	15/78 (19%)
		PRORP	286..>411	CDD:465320	37/160 (23%)