Protein Alignment NUP93 and NIC96

DIOPT Version :10

• Sequence 1: NP_055484.3
• Gene: NUP93 / 9688
• HGNCID: 28958
• Length: 819
• Species: Homo sapiens
• Sequence 2: NP_116657.1
• Gene: NIC96 / 850552
• SGDID: S000001898
• Length: 839
• Species: Saccharomyces cerevisiae
• Alignment Length: 875
• Identity: 223/875 - (25%)
• Similarity: 402/875 - (45%)
• Gaps: 127/875 - (14%)

Human     8 ELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLGSRGLDIS 72
            |||:.::.|.:.:   |||..::.::.|:::...:|||:  .:.|::.  .||..||.:.||...
Yeast    24 ELLESSDNLPSAS---SELGSIQVSINELRRRVFQLRSK--NKASKDY--TKAHYLLANSGLSFE 81

Human    73 HISQRLESLSAATTFEPLEP--VKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLV 135
            .:...::.|......||..|  ::..:::.:::.:|:..:|.:||:.........:.:...::.:
Yeast    82 DVDAFIKDLQTNQFLEPNPPKIIESEELEFYIRTKKEENILMSIEQLLNGATKDFDNFINHNLNL 146

Human   136 EWEQVKQRILHT--LLASGEDALDFTQESE------PSYISDVGPPGRSSLDNIEMA-------- 184
            :|.|.|..::..  :|...:..:|..:...      ||:    |..|.:.|::.|..
Yeast   147 DWAQHKNEVMKNFGILIQDKKTVDHKKSISSLDPKLPSW----GNKGNNILNSNESRLNVNENNI 207

Human   185 -------YARQIYIY-NEKIVNGH--LQPNLVDLCASVAELDDKSISDMWTMVKQMTDVLLTPAT 239
                   |||.::.: |.:..||:  :....:.:.:|.....:..:.:.|.:::.|..
Yeast   208 LREKFENYARIVFQFNNSRQANGNFDIANEFISILSSANGTRNAQLLESWKILESMKS------- 265

Human   240 DALKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVFGNLHQAQLG-GVPGTYQLVRSFLNIKLPA 303
               |:.:.|||..:       ||||.:..||     .||::..:. |:......::||::.||..
Yeast   266 ---KDINIVEVGKQ-------YLEQQFLQYT-----DNLYKKNMNEGLATNVNKIKSFIDTKLKK 315

Human   304 PLPGLQDGE---VEGHPVWALIYYCMRCGDLLAASQVV--NRAQHQLGE--FKTWFQEYMNSKDR 361
            .....:...   :.|.|:||||:|.:|.|.:..|.||:  |:|..:..|  |.|:|:.|.:|||.
Yeast   316 ADKSWKISNLTVINGVPIWALIFYLLRAGLIKEALQVLVENKANIKKVEQSFLTYFKAYASSKDH 380

Human   362 RLSPATENKLRLHYRRALRNNT--DPYKRAVYCIIGRCDVT-DNQSEVADKTEDYLWLKLNQVCF 423
            .|......||...|.:.::::.  |||:.|||.:|||||:: .|...|....||:||:.|..:..
Yeast   381 GLPVEYSTKLHTEYNQHIKSSLDGDPYRLAVYKLIGRCDLSRKNIPAVTLSIEDWLWMHLMLIKE 445

Human   424 DDDGTSSPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCH 488
            .|.......:|.:|..|| .::..||.|.|:     ..|.|.|.|:..:..|:.:.:....:  .
Yeast   446 KDAENDPVYERYSLEDFQ-NIIISYGPSRFS-----NYYLQTLLLSGLYGLAIDYTYTFSEM--D 502

Human   489 AVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFESTDPREALQYFYF 553
            |||:|:.|..|||.   ...|:..|:.:|     .|.:.|..:|..||:.|..:|||.|::|...
Yeast   503 AVHLAIGLASLKLF---KIDSSTRLTKKP-----KRDIRFANILANYTKSFRYSDPRVAVEYLVL 559

Human   554 LRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDK-----FTSDTKPIINKV- 612
            :...:......:....:.|||:|::||.::|||:..||:|.||||::     ...|.|..::.:
Yeast   560 ITLNEGPTDVELCHEALRELVLETKEFTVLLGKIGRDGARIPGVIEERQPLLHVRDEKEFLHTIT 624

Human   613 ---ASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLS----------PVVPQISAPQSNKERLK 664
               |..|:..|...::..||.||:..|.|:.|:|.|||          |:|    .|..|.|  .
Yeast   625 EQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSLLSDTLSASDLDQPLV----GPDDNSE--T 683

Human   665 NMALSIAER-----YRAQGISANKFVDS--TFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPL 722
            |..| :|.|     :...|||....|.:  ...|||::.:..:.|.:.........:|.|.|:|.
Yeast   684 NPVL-LARRMASIYFDNAGISRQIHVKNKEICMLLLNISSIRELYFNKQWQETLSQMELLDLLPF 747

Human   723 NQE-SVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIEDRDSQLR 786
            :.| |..::...|.|..|.|..|:..:|:.|::.:......|..:...||::.|::    || |:
Yeast   748 SDELSARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHILNESKYQSSTKGQQI----DS-LK 807

Human   787 SQARTLITFAGMIPYRTSGDTNARLVQMEV 816
            :.||..:.:||||.||...:|.:.|:.::|
Yeast   808 NVARQCMIYAGMIQYRMPRETYSTLINIDV 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP93	NP_055484.3	Nic96	218..810	CDD:461172	177/629 (28%)
NIC96	NP_116657.1	Nic96	252..831	CDD:461172	177/628 (28%)