Protein Alignment NUP93 and Nup93-1

DIOPT Version :10

• Sequence 1: NP_055484.3
• Gene: NUP93 / 9688
• HGNCID: 28958
• Length: 819
• Species: Homo sapiens
• Sequence 2: NP_572929.1
• Gene: Nup93-1 / 32350
• FlyBaseID: FBgn0027537
• Length: 823
• Species: Drosophila melanogaster
• Alignment Length: 834
• Identity: 290/834 - (34%)
• Similarity: 463/834 - (55%)
• Gaps: 37/834 - (4%)

Human     8 ELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLGSRGLDIS 72
            |||:||::|..||...:|:|.|||.:.::.||.:...||.   |...|.|::|.:||||:|:|:.
  Fly     5 ELLKQAQRLTNETNTDTEVPGVERTMSQVLQATKEFHSRV---TQMGTNDLQAHILLGSKGVDLP 66

Human    73 HISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEW 137
            .::|:||||||..||||::||.:|::|.:||||::||:||.|:|:.:..|...|......:..||
  Fly    67 KLTQKLESLSARQTFEPIDPVTETNVQAYLKNERENAILSVIDETNRSIFKSVERQKWRCIYSEW 131

Human   138 EQVKQRILHTLLA-SGEDALDFTQESEPSYISDVGPPGRSSLDNIEMAYARQIYIYNEKIVNGHL 201
            .:.|:.:|:.|:. :.:|..|...:..|:.::| .|...|.|:..|..||.||.|:|:.|:.|.
  Fly   132 GEEKEALLNALVGPNQQDFPDVQFQIVPTAMAD-EPTPYSQLNGHEQMYAEQIAIHNQSIILGR- 194

Human   202 QPNLVDLCASVAE--LDDKSISDMWTMVKQMTDVLLTPAT---DALKNRSSVEVRMEFVRQALAY 261
            :|||:...|.|.:  .:|:|:::||.:::.||  .|.|.:   |.:|||   :...:||.||..|
  Fly   195 RPNLLSTLAHVVQDSFNDESVAEMWNVLQFMT--ALPPVSSTIDPIKNR---QTSPQFVEQARTY 254

Human   262 LEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPA--PLPGLQDGEVEGHPVWALIYY 324
            ||:.|:.|....:..||.:|:.||:|..|.:|||::.:.|..  .|.||.|.. .|.|:|..:||
  Fly   255 LERRYRTYMRKFIVANLAKARRGGIPSVYHMVRSYVGVTLQGQRALYGLHDVN-NGQPLWPHVYY 318

Human   325 CMRCGDLLAASQVVNRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRA 389
            .:|.||:.||:..: :......:..|......|.....|....|.:|:|.|...||..|||||:|
  Fly   319 SLRSGDMDAAALYL-KESGTCPDLLTLLTLRKNGDRDNLMVKLEGQLKLEYNSRLRACTDPYKKA 382

Human   390 VYCIIGRCDVTDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFT 454
            ||.::..||......|:....:|:||::|: :....|.:.|..::||.|..|..:||.|||::|.
  Fly   383 VYVVLLACDPHFTHVELMRSIDDFLWMQLS-ILRRSDQSDSNTEQLTFSGLQSLILEKYGENYFN 446

Human   455 VNQQPFLYFQVLFLTAQFEAAVAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGD 519
            ..::..||||||.||.|||||:.||.|.|:.|.||:|:|:.|.|:.:|.........|||.:|.|
  Fly   447 AREKAALYFQVLTLTGQFEAAIEFLARTEKNRTHAIHMAIALNEISMLGTPRSVEQSLLSSDPDD 511

Human   520 PPCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGE-NMFLRCVSELVIESRE---F 580
            |..::|||.|||:::||:.||.||..:||.|:|.||:.|...|. |:.|.||.:|::|..:   .
  Fly   512 PKPMKRLNLVRLIVMYTKCFERTDTTQALHYYYLLRNFKSENGRGNVMLTCVCDLLVEKCDDEML 576

Human   581 DMILG-KLENDGSRKPGVIDKF---TSDTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLEL 641
            ::|.| :.:.:|.|..|:..:|   ..|...:...|......:|.:|.|.:||.:....||.|.|
  Fly   577 ELIFGTEDKKNGLRYGGIYAEFQIHECDKYSLAEMVGDELSKRGDYELAIELYFIGGQLDKALRL 641

Human   642 MNKLLSPVVPQISAPQSNKERLKNM--ALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHS 704
            :|.||:.||.|.:...|.:.||.::  .|..|...|...:.....|  |:.:|..::.|||.||.
  Fly   642 VNSLLAQVVHQPTQNGSVRNRLGDIINRLDAALVVRKSDVEVQVVV--TYTVLTKVMKFFDHYHE 704

Human   705 GHIDRAFDIIERLKLVPLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPS 769
            |.:..|.:|:....|:|.:...|:|.|...:....|:...|.::|||:|:|::.::.:|..::.:
  Fly   705 GALRSALEILTNNHLIPASSLEVDECVTNIKRMGPEVIKVLPDILLASMDIVYQEYVKLMDSNET 769

Human   770 SSS--RPQRVI--EDRDSQLRSQARTLITFAGMIPYRTSGDTNARLVQMEVLMN 819
            :|.  ...:.:  |.....||.:|:.....|..:|||....||.||||:|:||:
  Fly   770 ASGFFDESKCVNKEPAVKHLRDRAKAFTNMAASVPYRMPSTTNQRLVQLEILMH 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP93	NP_055484.3	Nic96	218..810	CDD:461172	202/610 (33%)
Nup93-1	NP_572929.1	Nic96	215..814	CDD:461172	201/608 (33%)